메뉴 건너뛰기




Volumn 32, Issue 2, 1996, Pages 219-230

Genetic polymorphism of S-mephenytoin 4'-hydroxylation

Author keywords

CYP2C19; genetic; hydroxylation; mephenytoin; polymorphism

Indexed keywords

AMITRIPTYLINE; CHLORPROGUANIL; CITALOPRAM; CLOMIPRAMINE; CYTOCHROME P450 ISOENZYME; DIAZEPAM; HEXOBARBITAL; IMIPRAMINE; MEPHENYTOIN; METHYLPHENOBARBITAL; MOCLOBEMIDE; NORDAZEPAM; NORMEPHENYTOIN; OMEPRAZOLE; PHENYTOIN; PROPRANOLOL;

EID: 0029783939     PISSN: 00485764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (32)

References (98)
  • 1
    • 9044243467 scopus 로고
    • Mesantoin in the treatment of epilepsy: A study of its effect on the leucocyte count in seventy-nine cases
    • Abbott, JA, and Schwab, RS. Mesantoin in the treatment of epilepsy: A study of its effect on the leucocyte count in seventy-nine cases. N. Engl. J. Med. 250:197-199, 1954.
    • (1954) N. Engl. J. Med. , vol.250 , pp. 197-199
    • Abbott, J.A.1    Schwab, R.S.2
  • 2
    • 9344255711 scopus 로고
    • Differential effect of cirrhosis on metabolism due to P450 2D6 and P450 2Cmp
    • Adedoyin, A; Arns, P; Richards, W; Wilkinson, GR; and Branch, RA. Differential effect of cirrhosis on metabolism due to P450 2D6 and P450 2Cmp (Abstract #121). Pharmacologist 35:176, 1993.
    • (1993) Pharmacologist , vol.35 , pp. 176
    • Adedoyin, A.1    Arns, P.2    Richards, W.3    Wilkinson, G.R.4    Branch, R.A.5
  • 3
    • 0028207548 scopus 로고
    • Stereoselective disposition of hexobarbital and its metabolites: Relationship to the S-mephenytoin polymorphisms in Caucasian and Chinese subjects
    • Adedoyin, A; Prakash, C; O'Shea, D; Blair, IA; and Wilkinson, GR. Stereoselective disposition of hexobarbital and its metabolites: Relationship to the S-mephenytoin polymorphisms in Caucasian and Chinese subjects. Pharmacogenetics 4:27-38, 1994.
    • (1994) Pharmacogenetics , vol.4 , pp. 27-38
    • Adedoyin, A.1    Prakash, C.2    O'Shea, D.3    Blair, I.A.4    Wilkinson, G.R.5
  • 4
    • 0028276695 scopus 로고
    • Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism
    • Andersson, T; Miners, JO; Veronese, ME; and Birkett, DJ. Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism. Br. J. Clin. Pharmacol. 37:597-606, 1994.
    • (1994) Br. J. Clin. Pharmacol. , vol.37 , pp. 597-606
    • Andersson, T.1    Miners, J.O.2    Veronese, M.E.3    Birkett, D.J.4
  • 6
    • 0024335072 scopus 로고
    • Effects of ketoconazole on the polymorphic 4′-hydroxylation of S-mephenytoin and debrisoquine
    • Atiba, JO; Blaschke, TF; and Wilkinson, GR. Effects of ketoconazole on the polymorphic 4′-hydroxylation of S-mephenytoin and debrisoquine. Br. J. Clin. Pharmacol. 28:161-165, 1989.
    • (1989) Br. J. Clin. Pharmacol. , vol.28 , pp. 161-165
    • Atiba, J.O.1    Blaschke, T.F.2    Wilkinson, G.R.3
  • 8
    • 0023905757 scopus 로고
    • GC and GC-MS procedures for simultaneous phenotyping with dextromethorphan and mephenytoin
    • Baumann, P, and Jonzier-Percy, M. GC and GC-MS procedures for simultaneous phenotyping with dextromethorphan and mephenytoin. Clin. Chem. Acta 171:211-222, 1988.
    • (1988) Clin. Chem. Acta , vol.171 , pp. 211-222
    • Baumann, P.1    Jonzier-Percy, M.2
  • 9
    • 0024580554 scopus 로고
    • Importance of genetic factors in the regulation of diazepam metabolism: Relationship to S-mephenytoin, but not debrisoquine hydroxylation phenotype
    • Bertilsson, L; Henthorn, TK; Sanz, E; Tybring, G; Sawe, J; and Villen, T. Importance of genetic factors in the regulation of diazepam metabolism: Relationship to S-mephenytoin, but not debrisoquine hydroxylation phenotype. Clin. Pharmacol. Ther. 45:348-355, 1989.
    • (1989) Clin. Pharmacol. Ther. , vol.45 , pp. 348-355
    • Bertilsson, L.1    Henthorn, T.K.2    Sanz, E.3    Tybring, G.4    Sawe, J.5    Villen, T.6
  • 11
    • 0016765201 scopus 로고
    • Pharmacokinetics of hexobarbital in acute hepatitis and after apparent recovery
    • Breimer, DD; Zilly, W; and Richter, E. Pharmacokinetics of hexobarbital in acute hepatitis and after apparent recovery. Clin. Pharmacol. Ther. 18:433-440, 1975.
    • (1975) Clin. Pharmacol. Ther. , vol.18 , pp. 433-440
    • Breimer, D.D.1    Zilly, W.2    Richter, E.3
  • 13
    • 0027272518 scopus 로고
    • Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark
    • Brosen, K; Skjelbo, E; and Flachs, H. Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark. Br. J. Clin. Pharmacol. 36:105-108, 1993.
    • (1993) Br. J. Clin. Pharmacol. , vol.36 , pp. 105-108
    • Brosen, K.1    Skjelbo, E.2    Flachs, H.3
  • 14
    • 0038179031 scopus 로고
    • Metabolic demethylation of 3-methyl-5-ethyl-5-phenylhydantoin (Mesantoin)
    • Butler, TC. Metabolic demethylation of 3-methyl-5-ethyl-5-phenylhydantoin (Mesantoin). J. Pharmacol. Exp. Ther. 104:299-308, 1952.
    • (1952) J. Pharmacol. Exp. Ther. , vol.104 , pp. 299-308
    • Butler, T.C.1
  • 15
    • 9344270123 scopus 로고
    • Quantitative studies of the physiological disposition of 3-methyl-5-ethyl-5-phenylhydantoin (Mesantoin) and 5-ethyl-5-phenylhydantoin (Nirvanol)
    • Butler, TC. Quantitative studies of the physiological disposition of 3-methyl-5-ethyl-5-phenylhydantoin (Mesantoin) and 5-ethyl-5-phenylhydantoin (Nirvanol). J. Pharmacol. Exp. Ther. 109:340-345, 1953.
    • (1953) J. Pharmacol. Exp. Ther. , vol.109 , pp. 340-345
    • Butler, T.C.1
  • 16
    • 9344269620 scopus 로고
    • A pharmacological comparison of the optical isomer of 5-ethyl-5-phenylhydantoin (Nirvanol) and of 3-methyl-5-ethyl-5-phenylhydantoin (Mesantoin)
    • Butler, TC, and Waddel, WJ. A pharmacological comparison of the optical isomer of 5-ethyl-5-phenylhydantoin (Nirvanol) and of 3-methyl-5-ethyl-5-phenylhydantoin (Mesantoin). J. Pharmacol. Exp. Ther. 110:120-125, 1954.
    • (1954) J. Pharmacol. Exp. Ther. , vol.110 , pp. 120-125
    • Butler, T.C.1    Waddel, W.J.2
  • 19
    • 0028260641 scopus 로고
    • The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
    • de Morais, SM; Wilkinson, GR; Blaisdell, KN; Meyer, UA; and Goldstein, JA. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J. Biol. Chem. 269 (22): 15419-15422, 1994a.
    • (1994) J. Biol. Chem. , vol.269 , Issue.22 , pp. 15419-15422
    • De Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, K.N.3    Meyer, U.A.4    Goldstein, J.A.5
  • 20
    • 0028044085 scopus 로고
    • Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese
    • de Morais, SM; Wilkinson, GR; Blaisdell, KN; Meyer, UA; and Goldstein, JA. Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol. Pharmacol. 46:594-598, 1994b.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 594-598
    • De Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, K.N.3    Meyer, U.A.4    Goldstein, J.A.5
  • 22
    • 0024319297 scopus 로고
    • Mephenytoin and sparteine oxidation: Genetic polymorphisms in Denmark
    • Drohse, A; Bathum, L; Brosen, K; and Gram, LF. Mephenytoin and sparteine oxidation: Genetic polymorphisms in Denmark. Br. J. Clin. Pharmacol. 27:620-625, 1989.
    • (1989) Br. J. Clin. Pharmacol. , vol.27 , pp. 620-625
    • Drohse, A.1    Bathum, L.2    Brosen, K.3    Gram, L.F.4
  • 23
    • 0018212813 scopus 로고
    • Preliminary observations on the pharmacokinetics of methylphenobarbitone
    • Eadie, MJ; Bochner, F; Hooper, WD; and Tyrer, JH. Preliminary observations on the pharmacokinetics of methylphenobarbitone. Clin. Exp. Neurol. 15:131-144, 1978.
    • (1978) Clin. Exp. Neurol. , vol.15 , pp. 131-144
    • Eadie, M.J.1    Bochner, F.2    Hooper, W.D.3    Tyrer, J.H.4
  • 24
    • 0029134950 scopus 로고
    • Phenytoin disposition and toxicity: Role of pharmacogenetic and interethnic factors
    • Edeki, TI, and Brase, DA. Phenytoin disposition and toxicity: Role of pharmacogenetic and interethnic factors. Drug Metab. Reviews 27(3):449-469, 1995.
    • (1995) Drug Metab. Reviews , vol.27 , Issue.3 , pp. 449-469
    • Edeki, T.I.1    Brase, D.A.2
  • 26
    • 0023219332 scopus 로고
    • Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans
    • Fritz, S; Linden, W; Roots, I; Frey, BM; and Kupfer, A. Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans. J. Pharmacol. Exp. Ther. 241:615-622, 1987.
    • (1987) J. Pharmacol. Exp. Ther. , vol.241 , pp. 615-622
    • Fritz, S.1    Linden, W.2    Roots, I.3    Frey, B.M.4    Kupfer, A.5
  • 27
    • 0025948746 scopus 로고
    • Polymerase chain reaction-directed identification, cloning and quantification of human CYP2C18 mRNA
    • Furuya, H; Meyer, UA; Gelboin, HV; and Gonzalez, FJ. Polymerase chain reaction-directed identification, cloning and quantification of human CYP2C18 mRNA. Mol. Pharmacol. 40:375-382, 1991.
    • (1991) Mol. Pharmacol. , vol.40 , pp. 375-382
    • Furuya, H.1    Meyer, U.A.2    Gelboin, H.V.3    Gonzalez, F.J.4
  • 29
    • 0029016328 scopus 로고
    • Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study
    • Gram, LF; Guentert, TW; Grange, S; Vistisen, K; and Brosen, K. Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study. Clin. Pharmacol. Ther. 57:670-677, 1995.
    • (1995) Clin. Pharmacol. Ther. , vol.57 , pp. 670-677
    • Gram, L.F.1    Guentert, T.W.2    Grange, S.3    Vistisen, K.4    Brosen, K.5
  • 31
    • 0026629691 scopus 로고
    • Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6
    • Heim, MH, and Meyer, UA. Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6. Genomics 14:49-58, 1992.
    • (1992) Genomics , vol.14 , pp. 49-58
    • Heim, M.H.1    Meyer, U.A.2
  • 32
    • 0025307263 scopus 로고
    • In vitro metabolism of the biguanide antimalarials in human liver microsomes: Evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme
    • Helsby, NA; Ward, SA; Howells, RE; and Breckenridge, AM. In vitro metabolism of the biguanide antimalarials in human liver microsomes: Evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme. Br. J. Clin. Pharmacol. 30:287-291, 1990.
    • (1990) Br. J. Clin. Pharmacol. , vol.30 , pp. 287-291
    • Helsby, N.A.1    Ward, S.A.2    Howells, R.E.3    Breckenridge, A.M.4
  • 34
    • 0022518942 scopus 로고
    • Genetic polymorphism of mephenytoin
    • Kalow W; Goedde, HW; and Agarwal, DP, eds. New York: Alan R Liss
    • Inaba, T. Genetic polymorphism of mephenytoin. In: Kalow W; Goedde, HW; and Agarwal, DP, eds. Ethnic Differences in Reactions To Drugs and Xenobiotics. New York: Alan R Liss, 1986. pp. 139-156.
    • (1986) Ethnic Differences in Reactions to Drugs and Xenobiotics , pp. 139-156
    • Inaba, T.1
  • 35
    • 0023919439 scopus 로고
    • Mephenytoin hydroxylation in the Cuna Amerindians of Panama
    • Inaba, T; Jorge, LF; and Arias, TD. Mephenytoin hydroxylation in the Cuna Amerindians of Panama. Br. J. Clin. Pharmacol. 25:75-79, 1988.
    • (1988) Br. J. Clin. Pharmacol. , vol.25 , pp. 75-79
    • Inaba, T.1    Jorge, L.F.2    Arias, T.D.3
  • 36
    • 0021690577 scopus 로고
    • Mephenytoin and sparteine pharmacogenetics in Canadian Caucasians
    • Inaba, T; Jurima, M; Nakano, M; and Kalow, W. Mephenytoin and sparteine pharmacogenetics in Canadian Caucasians. Clin. Pharmacol. Ther. 30:670-676, 1984.
    • (1984) Clin. Pharmacol. Ther. , vol.30 , pp. 670-676
    • Inaba, T.1    Jurima, M.2    Nakano, M.3    Kalow, W.4
  • 37
    • 0022503196 scopus 로고
    • Family studies of mephenytoin hydroxylation deficiency
    • Inaba, T; Jurima, M; and Kalow, W. Family studies of mephenytoin hydroxylation deficiency. Am. J. Hum. Genet. 38:768-772, 1986.
    • (1986) Am. J. Hum. Genet. , vol.38 , pp. 768-772
    • Inaba, T.1    Jurima, M.2    Kalow, W.3
  • 39
    • 9344233507 scopus 로고
    • The 4′-hydroxylation of (S)-mephenytoin in Nigerians: A population study
    • Ingelman-Sundberg, M; Gustafsson, JA; and Orrenius, S, eds. Stockholm: Karolinska Institutet
    • Iyun, AO; Tucker, GT; Woods, HF; and Lennard, MS. The 4′-hydroxylation of (S)-mephenytoin in Nigerians: A population study. In: Ingelman-Sundberg, M; Gustafsson, JA; and Orrenius, S, eds. Eighth International Symposium: Microsomes and Drug Oxidations. Stockholm: Karolinska Institutet, 1990.
    • (1990) Eighth International Symposium: Microsomes and Drug Oxidations
    • Iyun, A.O.1    Tucker, G.T.2    Woods, H.F.3    Lennard, M.S.4
  • 40
    • 0023762605 scopus 로고
    • Phenotyping polymorphic drug metabolism in French Caucasian population
    • Jacqz, E; Dulac, H; and Mathieu, H. Phenotyping polymorphic drug metabolism in French Caucasian population. Eur. J. Clin. Pharmacol. 35:167-171, 1988.
    • (1988) Eur. J. Clin. Pharmacol. , vol.35 , pp. 167-171
    • Jacqz, E.1    Dulac, H.2    Mathieu, H.3
  • 41
    • 0022623877 scopus 로고
    • Polymorphic metabolism of mephenytoin in man: Pharmacokinetic interaction with a co-regulated substrate, mephobarbitol
    • Jacqz, E; Hall, SD; Branch, RA; and Wilkinson, GR. Polymorphic metabolism of mephenytoin in man: Pharmacokinetic interaction with a co-regulated substrate, mephobarbitol. Clin. Pharmacol. Ther. 39:646-653, 1986.
    • (1986) Clin. Pharmacol. Ther. , vol.39 , pp. 646-653
    • Jacqz, E.1    Hall, S.D.2    Branch, R.A.3    Wilkinson, G.R.4
  • 42
    • 0022220338 scopus 로고
    • Genetic polymorphism of mephenytoin p-(4′) hydroxylation: Differences between Orientals and Caucasians
    • Jurima, M; Inaba, T; Kadar, D; and Kalow, W. Genetic polymorphism of mephenytoin p-(4′) hydroxylation: Differences between Orientals and Caucasians. Br. J. Clin. Pharmacol. 19:483-487, 1985.
    • (1985) Br. J. Clin. Pharmacol. , vol.19 , pp. 483-487
    • Jurima, M.1    Inaba, T.2    Kadar, D.3    Kalow, W.4
  • 43
    • 0023193252 scopus 로고
    • Genetic predisposition to bladder cancer: Ability to hydroxylate debrisoquine and mephenytoin as risk factors
    • Kaisary, A; Smith, P; Jacqz, E; McAllister, CB; Wilkinson, GR; Ray, WA; and Branch, RA. Genetic predisposition to bladder cancer: Ability to hydroxylate debrisoquine and mephenytoin as risk factors. Cancer Res. 47:5488-5493, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 5488-5493
    • Kaisary, A.1    Smith, P.2    Jacqz, E.3    McAllister, C.B.4    Wilkinson, G.R.5    Ray, W.A.6    Branch, R.A.7
  • 44
    • 0022454027 scopus 로고
    • The genetic defect of mephenytoin hydroxylation
    • Kalow, W. The genetic defect of mephenytoin hydroxylation. Xenobiotica 16:379-389, 1986.
    • (1986) Xenobiotica , vol.16 , pp. 379-389
    • Kalow, W.1
  • 45
    • 0027477948 scopus 로고
    • Polymorphism of debrisoquine and mephenytoin hydroxylation among Estonians
    • Kiivet, RA; Svensson, JO; Bertilsson, L; and Sjöqvist, F. Polymorphism of debrisoquine and mephenytoin hydroxylation among Estonians. Pharmacol. Toxicol. 72:113-115, 1993.
    • (1993) Pharmacol. Toxicol. , vol.72 , pp. 113-115
    • Kiivet, R.A.1    Svensson, J.O.2    Bertilsson, L.3    Sjöqvist, F.4
  • 47
    • 0017705222 scopus 로고
    • Stereoselective metabolism, pharmacokinetics and biliary elimination of phenylethylhydantoin (Nirvanol) in the dog
    • Kupfer, A; Bircher, J; and Preisig, R. Stereoselective metabolism, pharmacokinetics and biliary elimination of phenylethylhydantoin (Nirvanol) in the dog. J. Pharmacol. Exp. Ther. 203:493-499, 1977.
    • (1977) J. Pharmacol. Exp. Ther. , vol.203 , pp. 493-499
    • Kupfer, A.1    Bircher, J.2    Preisig, R.3
  • 48
    • 0022212549 scopus 로고
    • Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation
    • Kupfer, A, and Branch, RA. Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation. Clin. Pharmacol. Ther. 38:414-418, 1985.
    • (1985) Clin. Pharmacol. Ther. , vol.38 , pp. 414-418
    • Kupfer, A.1    Branch, R.A.2
  • 50
    • 0010934844 scopus 로고
    • Family study of a genetically determined deficiency of mephenytoin hydroxylation in man
    • Kupfer, A; Desmond, P; Schenker, S; and Branch, RA. Family study of a genetically determined deficiency of mephenytoin hydroxylation in man. Pharmacologist 21:173, 1979.
    • (1979) Pharmacologist , vol.21 , pp. 173
    • Kupfer, A.1    Desmond, P.2    Schenker, S.3    Branch, R.A.4
  • 51
    • 0019954836 scopus 로고
    • Stereoselective metabolism and disposition of the enantiomers of mephenytoin during chronic oral administration of the racemic drug in man
    • Kupfer, A; Desmond, P; Schenker, S; and Branch, RA. Stereoselective metabolism and disposition of the enantiomers of mephenytoin during chronic oral administration of the racemic drug in man. J. Pharmacol. Exp. Ther. 221:590-597, 1982.
    • (1982) J. Pharmacol. Exp. Ther. , vol.221 , pp. 590-597
    • Kupfer, A.1    Desmond, P.2    Schenker, S.3    Branch, R.A.4
  • 52
    • 0019832740 scopus 로고
    • Polymorphic mephenytoin hydroxylation in man: A new phenotype in the genetic control of hepatic drug metabolism
    • Kupfer, A; Dick, B; and Preisig, R. Polymorphic mephenytoin hydroxylation in man: A new phenotype in the genetic control of hepatic drug metabolism. Hepatology 81:34, 1981b.
    • (1981) Hepatology , vol.81 , pp. 34
    • Kupfer, A.1    Dick, B.2    Preisig, R.3
  • 53
    • 0021333271 scopus 로고
    • Stereoselectivity of the arene epoxide pathway of mephenytoin hydroxylation in man
    • Kupfer, A; Lawson, J; and Branch, RA. Stereoselectivity of the arene epoxide pathway of mephenytoin hydroxylation in man. Epilepsia 25:1-7, 1984b.
    • (1984) Epilepsia , vol.25 , pp. 1-7
    • Kupfer, A.1    Lawson, J.2    Branch, R.A.3
  • 54
    • 0021125904 scopus 로고
    • Stereoselective metabolism and pharmacogenetic control of 5-phenyl-5-ethylhydantoin (nirvanol) in humans
    • Kupfer, A; Patwardham, R; Ward, S; Schenker, S; Preisig, R; and Branch, RA. Stereoselective metabolism and pharmacogenetic control of 5-phenyl-5-ethylhydantoin (nirvanol) in humans. J. Pharmacol. Exp. Ther. 230:28-33, 1984.
    • (1984) J. Pharmacol. Exp. Ther. , vol.230 , pp. 28-33
    • Kupfer, A.1    Patwardham, R.2    Ward, S.3    Schenker, S.4    Preisig, R.5    Branch, R.A.6
  • 55
    • 0021237993 scopus 로고
    • Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man
    • Kupfer, A, and Preisig, R. Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man. Eur. J. Clin. Pharmacol. 26:753-759, 1984c.
    • (1984) Eur. J. Clin. Pharmacol. , vol.26 , pp. 753-759
    • Kupfer, A.1    Preisig, R.2
  • 57
    • 0004813782 scopus 로고
    • Mephenytoin and ethotoin
    • Woodbury, DM; Penny, JK; and Peppenger, CE, eds. New York: Raven Press
    • Kupferberg, HJ. Mephenytoin and ethotoin. In: Woodbury, DM; Penny, JK; and Peppenger, CE, eds. Antiepileptic Drugs. New York: Raven Press, 1982. pp. 283-295.
    • (1982) Antiepileptic Drugs , pp. 283-295
    • Kupferberg, H.J.1
  • 58
    • 0027755278 scopus 로고
    • Debrisoquine and mephenytoin hydroxylation phenotypes and CYP 2D6 genotype in patients treated with neuroleptic and antidepressant agents
    • Llerena, A; Herraiz, AG; Cobaleda, J; Johansson, I; and Dahl, ML. Debrisoquine and mephenytoin hydroxylation phenotypes and CYP 2D6 genotype in patients treated with neuroleptic and antidepressant agents. Clin. Pharmacol. Ther. 54:606-611, 1993a.
    • (1993) Clin. Pharmacol. Ther. , vol.54 , pp. 606-611
    • Llerena, A.1    Herraiz, A.G.2    Cobaleda, J.3    Johansson, I.4    Dahl, M.L.5
  • 59
    • 0027183673 scopus 로고
    • Reproducibility over time of mephenytoin and debrisoquine hydroxylation phenotypes
    • Llerena, LA; Valdivielso, MJ; Benitez, J; and Bertilsson, L. Reproducibility over time of mephenytoin and debrisoquine hydroxylation phenotypes. Pharmacol. Toxicol. 73:46-48, 1993b.
    • (1993) Pharmacol. Toxicol. , vol.73 , pp. 46-48
    • Llerena, L.A.1    Valdivielso, M.J.2    Benitez, J.3    Bertilsson, L.4
  • 60
    • 0018330592 scopus 로고
    • N-Acetyltransferase phenotype and risk in urinary bladder cancer: Approaches in molecular epidemiology. Preliminary results in Sweden and Denmark
    • Lower, GM; Nielsson, T; Nelson, CE; Wolf, H; Gamsky, TE; and Bryan, GT. N-Acetyltransferase phenotype and risk in urinary bladder cancer: Approaches in molecular epidemiology. Preliminary results in Sweden and Denmark. Environ. Health Perspect. 29:71-79, 1979.
    • (1979) Environ. Health Perspect. , vol.29 , pp. 71-79
    • Lower, G.M.1    Nielsson, T.2    Nelson, C.E.3    Wolf, H.4    Gamsky, T.E.5    Bryan, G.T.6
  • 61
    • 0029055448 scopus 로고
    • Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe
    • Masimirembwa, C; Bertilsson, L; Johansson, I; Hasler, JA; and Ingelman-Sundberg, M. Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe. Clin. Pharmacol. Ther. 57:656-661, 1995.
    • (1995) Clin. Pharmacol. Ther. , vol.57 , pp. 656-661
    • Masimirembwa, C.1    Bertilsson, L.2    Johansson, I.3    Hasler, J.A.4    Ingelman-Sundberg, M.5
  • 62
    • 0028237981 scopus 로고
    • Frequency distribution of dapsone N-hydroxylase, a putative probe for P450 3A4 activity, in a white population
    • May, DG; Porter, J; Wilkinson, GR; and Branch, RA. Frequency distribution of dapsone N-hydroxylase, a putative probe for P450 3A4 activity, in a white population. Clin. Pharmacol. Ther. 55:492-500, 1994.
    • (1994) Clin. Pharmacol. Ther. , vol.55 , pp. 492-500
    • May, D.G.1    Porter, J.2    Wilkinson, G.R.3    Branch, R.A.4
  • 63
    • 0022178173 scopus 로고
    • Interethnic differences in genetic polymorphism of debrisoquine and mephenytoin hydroxylation between Japanese and Caucasian populations
    • Nakamura, K; Goto, F; Ray, WA; McAllister, CB; Jacqz, E; and Wilkinson GR. Interethnic differences in genetic polymorphism of debrisoquine and mephenytoin hydroxylation between Japanese and Caucasian populations. Clin. Pharmacol. Ther. 38:402-408, 1985.
    • (1985) Clin. Pharmacol. Ther. , vol.38 , pp. 402-408
    • Nakamura, K.1    Goto, F.2    Ray, W.A.3    McAllister, C.B.4    Jacqz, E.5    Wilkinson, G.R.6
  • 64
    • 0028303496 scopus 로고
    • Single-dose kinetics of clomipramine: Relationship to the sparteine and S-mephenytoin oxidative polymorphisms
    • Nielsen, KK; Brosen, K; Hansen, MGJ; and Gram, LF. Single-dose kinetics of clomipramine: Relationship to the sparteine and S-mephenytoin oxidative polymorphisms. Clin. Pharmacol. Ther. 55:518-527, 1994.
    • (1994) Clin. Pharmacol. Ther. , vol.55 , pp. 518-527
    • Nielsen, K.K.1    Brosen, K.2    Hansen, M.G.J.3    Gram, L.F.4
  • 66
    • 0029042294 scopus 로고
    • The mephenytoin (cytochrome P450 2C19) and dextromethorphan (cytochrome P450 2D6) polymorphism in Saudi Arabians and Filipinos
    • Price-Evans, DA; Krahn, P; and Narayanan, N. The mephenytoin (cytochrome P450 2C19) and dextromethorphan (cytochrome P450 2D6) polymorphism in Saudi Arabians and Filipinos. Pharmacogenetics 5:64-71, 1995.
    • (1995) Pharmacogenetics , vol.5 , pp. 64-71
    • Price-Evans, D.A.1    Krahn, P.2    Narayanan, N.3
  • 67
    • 0025014594 scopus 로고
    • Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily
    • Relling, MV; Aoyama, T; Gonzalez, FJ; and Meyer, UA. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. J. Pharmacol. Exp. Ther. 252:442-447, 1990.
    • (1990) J. Pharmacol. Exp. Ther. , vol.252 , pp. 442-447
    • Relling, M.V.1    Aoyama, T.2    Gonzalez, F.J.3    Meyer, U.A.4
  • 69
    • 0025763625 scopus 로고
    • Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily
    • Romkes, M; Faletto, MB; Blaisdell, JA; Rancy, JL; and Goldstein, JA. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. Biochemistry 30:3247-3255, 1991.
    • (1991) Biochemistry , vol.30 , pp. 3247-3255
    • Romkes, M.1    Faletto, M.B.2    Blaisdell, J.A.3    Rancy, J.L.4    Goldstein, J.A.5
  • 71
    • 0028240671 scopus 로고
    • Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: Coincidence with plasma clearance and breath test
    • Rost, KL, and Roots, I. Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: Coincidence with plasma clearance and breath test. Clin. Pharmacol. Ther. 55:402-411, 1994.
    • (1994) Clin. Pharmacol. Ther. , vol.55 , pp. 402-411
    • Rost, K.L.1    Roots, I.2
  • 72
    • 9344229462 scopus 로고
    • Pharmackogenetik der Arzneinittelhydroxylierung hei Patienten nit primar vaskulaver pulmonaler Hypertonic (PVPH) nach Einnahme von Aminorex-Fumarat (AF, menocil)
    • Saner, H; Kupfer, A; Dick, B; and Gutner, HP. Pharmackogenetik der Arzneinittelhydroxylierung hei Patienten nit primar vaskulaver pulmonaler Hypertonic (PVPH) nach Einnahme von Aminorex-Fumarat (AF, menocil). Schweiz Med. Wochenschr 112:1634, 1982.
    • (1982) Schweiz Med. Wochenschr , vol.112 , pp. 1634
    • Saner, H.1    Kupfer, A.2    Dick, B.3    Gutner, H.P.4
  • 73
    • 0024336503 scopus 로고
    • S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin
    • Sanz, EJ; Villen, T; Alin, C; and Bertilsson, L. S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin. Clin. Pharmacol. Ther. 45:495-497, 1989.
    • (1989) Clin. Pharmacol. Ther. , vol.45 , pp. 495-497
    • Sanz, E.J.1    Villen, T.2    Alin, C.3    Bertilsson, L.4
  • 74
    • 0025358273 scopus 로고
    • Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects
    • Schellens, JHM; Van der Wart, JHF; and Breimer, DD. Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects. Br. J. Clin. Pharmacol. 29:665-671, 1990.
    • (1990) Br. J. Clin. Pharmacol. , vol.29 , pp. 665-671
    • Schellens, J.H.M.1    Van Der Wart, J.H.F.2    Breimer, D.D.3
  • 75
    • 0026633279 scopus 로고
    • Caution in the use of 100mg of racemic mephenytoin for phenotyping Southeastern Oriental subjects
    • Setiabudy, R; Chiba, K; Kusuka, M; and Ishizaki, T. Caution in the use of 100mg of racemic mephenytoin for phenotyping Southeastern Oriental subjects. Br. J. Clin. Pharmacol. 33:665-666, 1992.
    • (1992) Br. J. Clin. Pharmacol. , vol.33 , pp. 665-666
    • Setiabudy, R.1    Chiba, K.2    Kusuka, M.3    Ishizaki, T.4
  • 76
    • 0028030327 scopus 로고
    • Dapsone N-acetylation, metoprolol a-hydroxylation, and S-mephenytoin 4′-hydroxylation polymorphisms in an Indonesian population: A cocktail and extended phenotyping assessment trial
    • Setiabudy, R; Kusaka, M; Chiba, K; Darmansjah, I; and Ishizaki, T. Dapsone N-acetylation, metoprolol a-hydroxylation, and S-mephenytoin 4′-hydroxylation polymorphisms in an Indonesian population: A cocktail and extended phenotyping assessment trial. Clin. Pharmacol. Ther. 56:142-153, 1994.
    • (1994) Clin. Pharmacol. Ther. , vol.56 , pp. 142-153
    • Setiabudy, R.1    Kusaka, M.2    Chiba, K.3    Darmansjah, I.4    Ishizaki, T.5
  • 78
    • 0025964524 scopus 로고
    • The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine
    • Skjelbo, E; Brosen, K; Hallas, J; and Gram, LF. The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine. Clin. Pharmacol. Ther. 49:18-23, 1991.
    • (1991) Clin. Pharmacol. Ther. , vol.49 , pp. 18-23
    • Skjelbo, E.1    Brosen, K.2    Hallas, J.3    Gram, L.F.4
  • 79
    • 0026705708 scopus 로고
    • Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics
    • Sohn, DR; Kusaka, M; Ishizaki, T; Shin, SG; and Chiba, K. Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. Clin. Pharmacol. Ther. 52:160-169, 1992.
    • (1992) Clin. Pharmacol. Ther. , vol.52 , pp. 160-169
    • Sohn, D.R.1    Kusaka, M.2    Ishizaki, T.3    Shin, S.G.4    Chiba, K.5
  • 80
    • 0025916087 scopus 로고
    • Separation of human liver tolbutamide hydroxylase and (S)-mephenytoin 4′-hydroxylase cytochrome P-450 enzymes
    • Srivastava, PK; Yun, CH; Beaume, PH; Ged, C; and Guengerich, FP. Separation of human liver tolbutamide hydroxylase and (S)-mephenytoin 4′-hydroxylase cytochrome P-450 enzymes. Mol. Pharmacol. 40:69-79, 1991.
    • (1991) Mol. Pharmacol. , vol.40 , pp. 69-79
    • Srivastava, P.K.1    Yun, C.H.2    Beaume, P.H.3    Ged, C.4    Guengerich, F.P.5
  • 83
    • 0026934962 scopus 로고
    • A methodological investigation on the estimation of the S-mephenytoin hydroxylation phenotype using the urinary S/R ratio
    • Tybring, G, and Bertilsson, L. A methodological investigation on the estimation of the S-mephenytoin hydroxylation phenotype using the urinary S/R ratio. Pharmacogenetics 2:241-243, 1992.
    • (1992) Pharmacogenetics , vol.2 , pp. 241-243
    • Tybring, G.1    Bertilsson, L.2
  • 85
    • 0024534047 scopus 로고
    • Propranolol's metabolism is determined by both mephenytoin and debrisoquine hydroxylase activities
    • Ward, SA; Walle, T; Walle, UK; Wilkinson, GR; and Branch, RA. Propranolol's metabolism is determined by both mephenytoin and debrisoquine hydroxylase activities. Clin. Pharmacol. Ther. 45(1):72-79, 1989.
    • (1989) Clin. Pharmacol. Ther. , vol.45 , Issue.1 , pp. 72-79
    • Ward, S.A.1    Walle, T.2    Walle, U.K.3    Wilkinson, G.R.4    Branch, R.A.5
  • 86
    • 0024325077 scopus 로고
    • Pathwayselective sex differences in the metabolism of propranolol in human subjects
    • Walle, T; Walle, UK; Cowart, TD; and Conradi, EC. Pathwayselective sex differences in the metabolism of propranolol in human subjects. Clin. Pharmacol. Ther. 46:257-263, 1989.
    • (1989) Clin. Pharmacol. Ther. , vol.46 , pp. 257-263
    • Walle, T.1    Walle, U.K.2    Cowart, T.D.3    Conradi, E.C.4
  • 88
    • 0021684926 scopus 로고
    • Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism
    • Wedlund, PJ; Aslanian, WS; McAllister, CB; Wilkinson, GR; and Branch, RA. Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism. Clin. Pharmacol. Ther. 36:773-780, 1984.
    • (1984) Clin. Pharmacol. Ther. , vol.36 , pp. 773-780
    • Wedlund, P.J.1    Aslanian, W.S.2    McAllister, C.B.3    Wilkinson, G.R.4    Branch, R.A.5
  • 89
    • 0023155021 scopus 로고
    • Pharmacogenetic association between the formation of 4-OH-mephenytoin and a new metabolite of S-mephenytoin in man
    • Wedlund, PJ; Sweetman, BJ; Wilkinson, GR; and Branch, RA. Pharmacogenetic association between the formation of 4-OH-mephenytoin and a new metabolite of S-mephenytoin in man. Drug Metab. Dispos. 15:277-279, 1987.
    • (1987) Drug Metab. Dispos. , vol.15 , pp. 277-279
    • Wedlund, P.J.1    Sweetman, B.J.2    Wilkinson, G.R.3    Branch, R.A.4
  • 91
    • 0027445449 scopus 로고
    • Isolation and characterization of liver cytochrome P450 2C19: Correlation between 2C19 and S-mephenytoin 4′-hydroxylation
    • Wrighton, SA; Stevens, JC; Becker, GW; and Vanden Branden, M. Isolation and characterization of liver cytochrome P450 2C19: Correlation between 2C19 and S-mephenytoin 4′-hydroxylation. Arch. Biochem. Biophys. 306:240-245, 1993.
    • (1993) Arch. Biochem. Biophys. , vol.306 , pp. 240-245
    • Wrighton, S.A.1    Stevens, J.C.2    Becker, G.W.3    Vanden Branden, M.4
  • 92
    • 0025253095 scopus 로고
    • Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2
    • Yasumori, T; Murayama, N; Yamazoe, Y; and Kato, R. Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2. Clin. Pharmacol. Ther. 47:313-322, 1990.
    • (1990) Clin. Pharmacol. Ther. , vol.47 , pp. 313-322
    • Yasumori, T.1    Murayama, N.2    Yamazoe, Y.3    Kato, R.4
  • 93
    • 0025761936 scopus 로고
    • Cytochrome P-450 human-2(P-450IIC9) in mephenytoin hydroxylation polymorphism in human livers: Differences in substrate and stereoselectivities among microheterogenous P-450IIC species expressed in yeasts
    • Yasumori, T; Murayama, N; Yamazoe, Y; and Kato, R. Cytochrome P-450 human-2(P-450IIC9) in mephenytoin hydroxylation polymorphism in human livers: Differences in substrate and stereoselectivities among microheterogenous P-450IIC species expressed in yeasts. J. Biochem. 109:711-717, 1991.
    • (1991) J. Biochem. , vol.109 , pp. 711-717
    • Yasumori, T.1    Murayama, N.2    Yamazoe, Y.3    Kato, R.4
  • 94
    • 0024602413 scopus 로고
    • Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system
    • Yasumori, T; Yamazoe, Y; Abe, A; Nogi, Y; Fukasawa, T; and Kato, R. Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system. Mol. Pharmacol. 35:443-449, 1989.
    • (1989) Mol. Pharmacol. , vol.35 , pp. 443-449
    • Yasumori, T.1    Yamazoe, Y.2    Abe, A.3    Nogi, Y.4    Fukasawa, T.5    Kato, R.6
  • 96
    • 0025223056 scopus 로고
    • Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: Interethnic differences in comparison with white subjects
    • Zhang, Y; Reviriego, J; Lou, Y; Sjöqvist, F; and Bertilsson, L. Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: Interethnic differences in comparison with white subjects. Clin. Pharmacol. Ther. 48:496-502, 1990.
    • (1990) Clin. Pharmacol. Ther. , vol.48 , pp. 496-502
    • Zhang, Y.1    Reviriego, J.2    Lou, Y.3    Sjöqvist, F.4    Bertilsson, L.5
  • 98
    • 0017855050 scopus 로고
    • Hexobarbital disposition in compensated and decompensated cirrhosis of the liver
    • Zilly, W; Breimer, DD; and Richter, E. Hexobarbital disposition in compensated and decompensated cirrhosis of the liver. Clin. Pharmacol. Ther. 23:525-534, 1978.
    • (1978) Clin. Pharmacol. Ther. , vol.23 , pp. 525-534
    • Zilly, W.1    Breimer, D.D.2    Richter, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.