Genotype analysis of the CYP2C19 gene in HCV-seropositive patients with cirrhosis and hepatocellular carcinoma

Life Sciences

Volumn 67, Issue 14, 2000, Pages 1719-1724

  Chau, Tommy K H ^a   Murakami, Shigeto ^a,c   Kawai, Bumpei ^a   Nasu, Kayoko ^b   Kubota, Takahiro ^b   Ohnishi, Akihiro ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SRL INC   (Japan)

^c NONE   (Japan)

Author keywords

Cirrhosis; CYP2C19 gene polymorphism; Hepatitis C; Hepatocellular carcinoma; Japanese

Indexed keywords

4' HYDROXYMEPHENYTOIN; DRUG METABOLIZING ENZYME;

ARTICLE; ASIAN; CANCER RISK; CLINICAL ARTICLE; CONTROLLED STUDY; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; JAPAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FUNCTION TEST; PHARMACOGENETICS; PHENOTYPE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ALLELES; ARYL HYDROCARBON HYDROXYLASES; CARCINOMA, HEPATOCELLULAR; CYTOCHROME P-450 ENZYME SYSTEM; GENOTYPE; HEPACIVIRUS; HEPATITIS C; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MIXED FUNCTION OXYGENASES; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

HEPATITIS C VIRUS;

EID: 0034714521     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(00)00757-8     Document Type: Article

References (20)

1. Risk factors for hepatocellular carcinoma among patients with chronic liver disease
2. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma
3. Hepatitis C-associated hepatocellular carcinoma
4. Does hepatitis C virus cause hepatocellular carcinoma?
5. Hepatocellular carcinoma in Italian patients with cirrhosis
6. Prospective study of early detection of hepatocellular carcinama in patients with cirrhosis
7. Hepatitis C virus and hepatocellular carcinoma
8. Human drug-metabolizing enzyme polymorphisms: Effects on risk of toxicity and cancer
9. Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese
10. Genotyping of S-mephenytoin 4'-hydroxylation in an extended Japanese population
11. Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations
12. Lack of correlation between hepatitis C virus genotypes and clinical course of hepatitis C virus-related cirrhosis
13. Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: A prospective study
14. CYP2D6 genes and risk of liver cancer
15. CYP2A6 gene polymorphism and risk of liver cancer
16. Genetic predisposition to bladder cancer: Ability to hydroxylate debrisoquine and mephenytoin as risk factors
17. Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk
18. Lung cancer risk in relation to mephenytoin hydroxylation activity
19. Genotype analysis of the CYP2C19 gene in the Japanese population
20. Selective effect of liver disease on the activities of specific metabolizing enzymes: Investigation of cytochromes P450 2C19 and 2D6