Role of CYP2C19 in stereoselective hydroxylation of mephobarbital by human liver microsomes

Drug Metabolism and Disposition

Volumn 29, Issue 1, 2001, Pages 36-40

  Kobayashi, Kaoru ^a,b   Kogo, Mari ^b   Tani, Masayoshi ^c   Shimada, Noriaki ^d   Ishizaki, Takashi ^e   Numazawa, Satoshi ^b   Yoshida, Takemi ^b   Yamamoto, Toshinori ^b   Kuroiwa, Yukio ^b   Chiba, Kan ^a  

^a CHIBA UNIVERSITY   (Japan)

^b SHOWA UNIVERSITY   (Japan)

^c NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^d DAIICHI PURE CHEMICALS CO LTD   (Japan)

^e KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2C19; MEPHENYTOIN; METHYLPHENOBARBITAL; OXYGENASE;

ARTICLE; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; ENANTIOMER; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; LIVER MICROSOME; LIVER MICROSOME METABOLISM; PRIORITY JOURNAL;

ARYL HYDROCARBON HYDROXYLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; HUMANS; HYDROXYLATION; MEPHOBARBITAL; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; RECOMBINANT PROTEINS;

EID: 0035149429     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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7. Anisole
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11. Identification of CYP isoforms involved in citalopram N-demethylation by human liver microsomes
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13. Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation
14. Stereoselective metabolism and pharmacokinetics of racemic methylphenobarbital in humans
15. Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: Difference in chiral preference of CYP2C9 and CYP2C19
16. Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2