In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes

Drug Metabolism and Disposition

Volumn 29, Issue 9, 2001, Pages 1173-1175

  Barecki, M E ^a   Casciano, C N ^a   Johnson, W W ^a   Clement, R P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYDESLORATADINE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DESLORATADINE; DRUG METABOLITE; ENZYME INHIBITOR; LORATADINE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DRUG METABOLISM; ENZYME INHIBITION; HUMAN; IC 50; IN VITRO STUDY; LIVER MICROSOME; PRIORITY JOURNAL;

ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HISTAMINE H1 ANTAGONISTS; HUMANS; LORATADINE; MIXED FUNCTION OXYGENASES; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES;

EID: 0034876431     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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