메뉴 건너뛰기




Volumn 286, Issue 3, 1998, Pages 1490-1495

Identification of new human CYP2C19 alleies (CYP2C196 and CYP2C192B) in a caucasian poor metabolizer of mephenytoin

Author keywords

[No Author keywords available]

Indexed keywords

MEPHENYTOIN; TOLBUTAMIDE; ANTICONVULSIVE AGENT; CYP2C19 PROTEIN, HUMAN; CYTOCHROME P450; MIXED FUNCTION OXIDASE; UNSPECIFIC MONOOXYGENASE;

EID: 0032159423     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (130)

References (42)
  • 1
    • 0028207548 scopus 로고
    • Stereo selective disposition of hexobarbital and its metabolites: Relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects
    • Adedoyin A, Prakash C, O'Shea D, Blair IA and Wilkinson GR (1994) Stereo selective disposition of hexobarbital and its metabolites: Relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects. Pharmacogenetics 4:27-38.
    • (1994) Pharmacogenetics , vol.4 , pp. 27-38
    • Adedoyin, A.1    Prakash, C.2    O'Shea, D.3    Blair, I.A.4    Wilkinson, G.R.5
  • 2
    • 0026816971 scopus 로고
    • Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects
    • Andersson T, Regardh C-G, Lou Y-C, Zhang Y, Dahl ML and Bertilsson L (1992) Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects. Pharmacogenetics 2:25-31.
    • (1992) Pharmacogenetics , vol.2 , pp. 25-31
    • Andersson, T.1    Regardh, C.-G.2    Lou, Y.-C.3    Zhang, Y.4    Dahl, M.L.5    Bertilsson, L.6
  • 4
    • 0025994649 scopus 로고
    • Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase
    • Barnes HJ, Arlotto MP and Waterman MR (1991) Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli PNAS(USA) 88:5597-5601.
    • (1991) Escherichia Coli PNAS(USA) , vol.88 , pp. 5597-5601
    • Barnes, H.J.1    Arlotto, M.P.2    Waterman, M.R.3
  • 5
    • 0022692071 scopus 로고
    • Amitriptyline pharmacokinetics and clinical response. II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin
    • Baumann P, Jonzier-Perez M, Kerb L, Kupfer A, Tingueley D and Schöpf J (1956) Amitriptyline pharmacokinetics and clinical response. II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin. Int Clin Psychophirmacol 1:102-112.
    • (1956) Int Clin Psychophirmacol , vol.1 , pp. 102-112
    • Baumann, P.1    Jonzier-Perez, M.2    Kerb, L.3    Kupfer, A.4    Tingueley, D.5    Schöpf, J.6
  • 6
    • 0030965011 scopus 로고    scopus 로고
    • Lung cancer risk in relation to mephenytoin hydroxylation activity
    • Benhamou S, Bouchardy C and Dayer P (1997) Lung cancer risk in relation to mephenytoin hydroxylation activity. Pharmacogenetics 7:157-159.
    • (1997) Pharmacogenetics , vol.7 , pp. 157-159
    • Benhamou, S.1    Bouchardy, C.2    Dayer, P.3
  • 7
    • 0024580554 scopus 로고
    • Importance of genetic factors in the regulation of diazepam metabolism: Relationship to S-mephenytoin but not debrisoquine hydroxylation phenotype
    • Bertilsson L, Henthorn TK, Sanz E, Tybring G, Säwe J and Villen T (1989) Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin but not debrisoquine hydroxylation phenotype. Clin Pharmacol Ther 45:348-355.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 348-355
    • Bertilsson, L.1    Henthorn, T.K.2    Sanz, E.3    Tybring, G.4    Säwe, J.5    Villen, T.6
  • 8
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochim 72:248-254.
    • (1976) Anal Biochim , vol.72 , pp. 248-254
    • Bradford, M.1
  • 9
    • 0028865992 scopus 로고
    • A multifamily study on the relationship between CYP2C19 genotype and S-mephenytoin oxidation phenotype
    • Br0sen K, deMorais SMF, Meyer UA and Goldstein JA (1995) A multifamily study on the relationship between CYP2C19 genotype and S-mephenytoin oxidation phenotype. Pharmacogenetics 5:312-317.
    • (1995) Pharmacogenetics , vol.5 , pp. 312-317
    • Brosen, K.1    Demorais, S.M.F.2    Meyer, U.A.3    Goldstein, J.A.4
  • 11
    • 0028044085 scopus 로고
    • Identification of a new genetic defect responsible for the polymorphism of S-mephenytoin metabolism in Japanese
    • de Morais SMF, Wilkinson GR, Blaisdell J, Nakamura K, Meyer UA and Goldstein JA (1994b) Identification of a new genetic defect responsible for the polymorphism of S-mephenytoin metabolism in Japanese. Mol Pharmacol 46:594-598.
    • (1994) Mol Pharmacol , vol.46 , pp. 594-598
    • Smf, M.1    Wilkinson, G.R.2    Blaisdell, J.3    Nakamura, K.4    Meyer, U.A.5    Goldstein, J.A.6
  • 14
    • 0026601458 scopus 로고
    • Site-directed mutagensis of virtually any plasmid by eliminating a unique site
    • Deng WP and Nickoloff JA (1992) Site-directed mutagensis of virtually any plasmid by eliminating a unique site. Anal Biochem 200:81-88.
    • (1992) Anal Biochem , vol.200 , pp. 81-88
    • Deng, W.P.1    Nickoloff, J.A.2
  • 16
    • 0029782373 scopus 로고    scopus 로고
    • Genetic tests which identify the principle defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolism
    • (ed. by E. F. Johnson and M. R.Waterman) Academic Press, San Diego, CA
    • Goldstein JA and Blaisdell J (1996) Genetic tests which identify the principle defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolism in Methods in Enzymology:, Vol 272,Cytochrome P450, Part B, (ed. by E. F. Johnson and M. R.Waterman) pp. 210-217, Academic Press, San Diego, CA.
    • (1996) Methods in Enzymology:, Vol 272,Cytochrome P450, Part B , pp. 210-217
    • Goldstein, J.A.1    Blaisdell, J.2
  • 18
    • 0030904031 scopus 로고    scopus 로고
    • Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American Black populations
    • Goldstein JA, Ishizaki T, Chiba K, de Morais SMF, Bell D, Krahn PM and Price Evans DA (1997) Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American Black populations. Pharmacogenetics 7:59-64.
    • (1997) Pharmacogenetics , vol.7 , pp. 59-64
    • Goldstein, J.A.1    Ishizaki, T.2    Chiba, K.3    De Morais, S.M.F.4    Bell, D.5    Krahn, P.M.6    Price Evans, D.A.7
  • 19
    • 0026542989 scopus 로고
    • Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences
    • Gotoh 0 (1992) Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. J Biol Chem 267:83-90.
    • (1992) J Biol Chem , vol.267 , pp. 83-90
    • Gotoh, O.1
  • 21
  • 22
    • 15844394255 scopus 로고    scopus 로고
    • Identification of residues 99, 220 and 221 of human cytochrome P450 2C19 as key determinants of omeprazole hydroxylase activity
    • Ibeanu GC, Ghanayem BI, Linko P, Leiping L, Pedersen LG and Goldstein JA (1996) Identification of residues 99, 220 and 221 of human cytochrome P450 2C19 as key determinants of omeprazole hydroxylase activity. J Biol Chem 271:12496-12501.
    • (1996) J Biol Chem , vol.271 , pp. 12496-12501
    • Ibeanu, G.C.1    Ghanayem, B.I.2    Linko, P.3    Leiping, L.4    Pedersen, L.G.5    Goldstein, J.A.6
  • 24
    • 0021237993 scopus 로고
    • Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man
    • Kupfer A and Preisig R (1984) Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man. Sur J Clin Pharmacol 26:753-759.
    • (1984) Sur J Clin Pharmacol , vol.26 , pp. 753-759
    • Kupfer, A.1    Preisig, R.2
  • 25
    • 0022212549 scopus 로고
    • Stereo selective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation
    • Kupfer A and Branch RA (1985) Stereo selective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation. Clin Pharmacol Ther 38:414-418.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 414-418
    • Kupfer, A.1    Branch, R.A.2
  • 26
    • 0028303496 scopus 로고
    • Single-dose kinetics of clomipramine: Relationship to the sparteine/debrisoquine and S-mephenytoin oxidation polymorphisms
    • Nielsen KK, Br0sen K, Hansen J and Gram LF (1994) Single-dose kinetics of clomipramine: relationship to the sparteine/debrisoquine and S-mephenytoin oxidation polymorphisms. Clin Pharmacol Ther 55:518-527.
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 518-527
    • Nielsen, K.K.1    Brosen, K.2    Hansen, J.3    Gram, L.F.4
  • 27
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes
    • Omura T and Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. J Biol Chem 239:2370-2378.
    • (1964) J Biol Chem , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 29
    • 0025763625 scopus 로고
    • Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily
    • Romkes M, Faletto MB, Blaisdell J, Raucy JL and Goldstein JA (1991) Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. Biochemistry 30:3247-3255.
    • (1991) Biochemistry , vol.30 , pp. 3247-3255
    • Romkes, M.1    Faletto, M.B.2    Blaisdell, J.3    Raucy, J.L.4    Goldstein, J.A.5
  • 31
    • 0027472058 scopus 로고
    • Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms
    • Sindrup SH, Br0sen K, Hansen MGJ, Aaes-Jorgensen T, Overo KF and Gram LF (1993) Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms. Ther Drug Monit 13:11-17.
    • (1993) Ther Drug Monit , vol.13 , pp. 11-17
    • Sindrup, S.H.1    Brosen, K.2    Mgj, H.3    Aaes-Jorgensen, T.4    Overo, K.F.5    Gram, L.F.6
  • 32
    • 0025964524 scopus 로고
    • The mephenytoin oxidative polymorphism is partially responsible for the N-demethylation of imipramine
    • Skjelbo E, Br0sen K, Hallas J and Gram LF (1991) The mephenytoin oxidative polymorphism is partially responsible for the N-demethylation of imipramine. Clin Pharmacol Ther 49:18-23.
    • (1991) Clin Pharmacol Ther , vol.49 , pp. 18-23
    • Skjelbo, E.1    Brosen, K.2    Hallas, J.3    Gram, L.F.4
  • 33
    • 0002752973 scopus 로고
    • Improved media for growing plasmid and cosmid clones
    • Tartof KD and Hobbs CA (1987) Improved media for growing plasmid and cosmid clones. Bethesda Res Lab Focus 9:19.
    • (1987) Bethesda Res Lab Focus , vol.9 , pp. 19
    • Tartof, K.D.1    Hobbs, C.A.2
  • 34
    • 0024534047 scopus 로고
    • Propranolol's metabolism is determined by both mephenytoin and debrisoquine hydroxylase activities
    • Ward SA, Walle T, Walle UK, Wilkinson GR and Branch RA (1989) Propranolol's metabolism is determined by both mephenytoin and debrisoquine hydroxylase activities. Clin Pharmacol Ther 45:72-79.
    • (1989) Clin Pharmacol Ther , vol.45 , pp. 72-79
    • Ward, S.A.1    Walle, T.2    Walle, U.K.3    Wilkinson, G.R.4    Branch, R.A.5
  • 36
    • 0025735576 scopus 로고    scopus 로고
    • The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism - A panel study
    • The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism - a panel study. Br J din Pharmacol 31: 689-692.
    • Br J Din Pharmacol , vol.31 , pp. 689-692
  • 37
    • 0021359112 scopus 로고
    • Direct enantiomeric resolution of mephenytoin and its N-demethylated metabolite in plasma and blood using chiral capillary gas chromatography
    • Wedlund PJ, Sweetman BJ, McAllister CB, Branch RA and Wilkinson GR (1984) Direct enantiomeric resolution of mephenytoin and its N-demethylated metabolite in plasma and blood using chiral capillary gas chromatography. J Chromatogr B Biomed Appl 307:121-127.
    • (1984) J Chromatogr B Biomed Appl , vol.307 , pp. 121-127
    • Wedlund, P.J.1    Sweetman, B.J.2    McAllister, C.B.3    Branch, R.A.4    Wilkinson, G.R.5
  • 38
    • 0023155021 scopus 로고
    • Pharmacogenetic association between the formation of 4-hdroxymephenytion and a new metabolite of S-mephenytoin in man
    • Wedlund PJ, Sweetman BJ, Wilkinson GR and Branch RA (1987) Pharmacogenetic association between the formation of 4-hdroxymephenytion and a new metabolite of S-mephenytoin in man. Drug Metab Dispos 15:277-279.
    • (1987) Drug Metab Dispos , vol.15 , pp. 277-279
    • Wedlund, P.J.1    Sweetman, B.J.2    Wilkinson, G.R.3    Branch, R.A.4
  • 40
    • 0027445449 scopus 로고
    • Isolation and characterization of human liver cytochrome P450 2C19: Correlation between 2C19 and S-mephenytoin 4'-hydroxylation
    • Wrighton SA, Stevens JC, Becker GW and VandenBranden M (1993) Isolation and characterization of human liver cytochrome P450 2C19: Correlation between 2C19 and S-mephenytoin 4'-hydroxylation. Arch Biochem Biophys 306:240-245.
    • (1993) Arch Biochem Biophys , vol.306 , pp. 240-245
    • Wrighton, S.A.1    Stevens, J.C.2    Becker, G.W.3    Vandenbranden, M.4
  • 41
    • 8244249473 scopus 로고    scopus 로고
    • Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele
    • Xiao ZS, Goldstein JA, Xie H-G, Blaisdell J, Wang W, Jiang C-H, Yan F-X, He N, Huang S-L, Xu Z-H and Zhou H-H (1997) Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele. J Pharmacol Exper Ther 281:604-609.
    • (1997) J Pharmacol Exper Ther , vol.281 , pp. 604-609
    • Xiao, Z.S.1    Goldstein, J.A.2    Xie, H.-G.3    Blaisdell, J.4    Wang, W.5    Jiang, C.-H.6    Yan, F.-X.7    He, N.8    Huang, S.-L.9    Xu, Z.-H.10    Zhou, H.-H.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.