T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes

Journal of Autoimmunity

Volumn 9, Issue 3, 1996, Pages 385-389

  Lohmann, Tobias ^a   Leslie, R David G ^b   Londei, Marco ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b NONE

Author keywords

Epitopes; Glutamic acid decarboxylase; HLA restriction; Insulin dependent diabetes; T cell clones

Indexed keywords

AUTOANTIGEN; GLUTAMATE DECARBOXYLASE;

CELL CLONING; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; HLA TYPING; HUMAN; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; T LYMPHOCYTE; TWINS;

EID: 0030175881     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0052     Document Type: Conference Paper

References (17)

1. 1. Baekkeskov S., Aanstoot H., Christgau S., Reetz A., Solimena M., Cascalho M., Folli F., Richter-Olesen H., De Camilli P. 1990. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347: 151-156
2. 2. Christie M.R., Tun R.Y.M., Lo S.S.S., Cassidy D., Brown T.J., Hollands J., Shattock M., Botazzo G.F., Leslie R.D.G. 1992. Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM. Diabetes 41: 782-787
3. 3. Atkinson M.A., Bowman M.A., Campbell L., Darrow B.L., Kaufman D.L., Maclaren N.K. 1994. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J. Clin. Invest. 94: 2125-2129
4. 4. Honeyman M.C., Cram D.S., Harrison L.C. 1993. Glutamic acid decarboxylase 67-reactive T cells. J. Exp. Med. 177: 535-540
5. 5. Lohmann T., Leslie R.D.G., Hawa M., Geysen M., Rodda S., Londei M. 1994. Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus. Lancet 343: 1607-1608
6. 6. Kaufman D.L., Clare-Salzler M., Tian J., Forsthuber T., Ting G.S.P., Robinson P., Atkinson M.A., Sercarz E.E., Tobin A.J., Lehmann P.V. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72
7. 7. Tisch R., Yang X., Singer S.M., Liblau R.S., Fugger L., McDevitt H.O. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366: 72-75
8. 8. Zhang J., Weiner H.L., Hafler D.A. 1992. Autoreactive T-cells in multiple sclerosis. Int. Rev. Immunol. 9: 183-201
9. 9. Picard J. 1993. Single-step allele-specific polymerase chain reaction HLA-DQ genotyping using ARMS primers. Human Immunology 38: 115-122
10. 10. Reece J.C., Geysen H.M., Rodda S.J. 1993. Mapping the major human T helper epitopes of tetanus toxin. J. Immunol. 151: 6175-6184
11. 11. Tanigaki N., Fruci D., Groome N., Butler R.H., Londei M., Tosi R. 1994. Exploring myelin basic protein for HLA class I-binding sequences. Eur. J. Immunol. 24: 2196-2202
12. 12. Neitzel H. 1986. A routine method for the establishment of permanent growing lymphoblastoid cell lines. Human Genetics 73: 320-326
13. 13. Brown J.H., Jardetzky T.S., Gorga J.C., Stern L.J., Urban R.G., Strominger J.L., Wiley D.C. 1993. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364: 33-39
14. 14. Jones D.B., Coulson A.F.W., Duff G.W. 1993. Sequence homologies between hsp60 and autoantigens. Immunol. Today 14: 115-118
15. 15. Rudy G., Stone N., Harrison L.C., Colman P.G., McNair P., Brusic V., French M.B., Honeyman M.C., Tait B., Lew A.M. Similar peptides from two β cell autoantigens, proinsulin, and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Molecular Medicine 1: 625-633
16. 16. Hammer J., Valsani P., Tolba K., Bolin D., Higelin J., Takacs B., Sinigaglia F. 1993. Promiscuous and allele-specific anchors in HLA-DR binding peptides. Cell 74: 197-203
17. 17. Quaratino S., Feldmann M., Dayan C.M., Acuto O., Londei M. 1996. Human self-reactive T cell clones expressing identical TCRβ chains differ in their ability to recognize a cryptic self-epitope. J. Exp. Med. 183: 349-358