New inhibitors of poly(ADP-ribose) polymerase and their potential therapeutic targets

Expert Opinion on Therapeutic Patents

Volumn 12, Issue 7, 2002, Pages 1047-1071

  Cosi, Cristina ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Cancer; Inflammation; Ischaemia; Neurodegeneration; PARP inhibitors; Poly(ADP ribose)polymerase (PARP)

Indexed keywords

1,5 DIHYDROXYISOQUINOLINE; 3 AMINOBENZAMIDE; ANTINEOPLASTIC AGENT; AROMATIC COMPOUND; BENZAMIDE; BENZAMIDE DERIVATIVE; BENZYLAMINE DERIVATIVE; CARBONYL DERIVATIVE; CHLORMETHINE; DNA; DNA BINDING PROTEIN; ENZYME INHIBITOR; GPI 6150; INDOLE DERIVATIVE; ISOCARBOSTYRIL DERIVATIVE; ISOQUINOLINE DERIVATIVE; LACTAM DERIVATIVE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; NUCLEAR PROTEIN; PD 128763; PHENANTHRIDINE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON; REACTIVE OXYGEN METABOLITE; TEMOZOLOMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER; CANCER CHEMOTHERAPY; CELL DAMAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DNA METABOLISM; DRUG BRAIN LEVEL; DRUG DESIGN; DRUG POTENCY; DRUG POTENTIATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME REGULATION; GENETIC STABILITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; ISCHEMIA; MOUSE; NERVE DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATENT; PATHOPHYSIOLOGY; RAT; REGULATORY MECHANISM; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0036319115     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.12.7.1047     Document Type: Review

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