PARP inhibitors and cardioprotection

PARP as a Therapeutic Target

Volumn , Issue , 2002, Pages 117-133

  Thiemermann, Christoph ^a   Wayman, Nicole ^a   McDonald, Michelle C ^b   Chatterjee, Prabal Kumar ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0009796884     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (32)

1. Schraufstatter, I. U. et al., Hydrogen peroxide induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase, Proc. Natl. Acad. Sci. U.S.A., 82, 4908, 1996.
2. Pieper, A. A. et al., Poly(ADP-ribose) polymerase, nitric oxide and cell death, Trends Pharmacol. Sci., 20, 171, 1999.
3. Szabó, C. et al., DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite, Proc. Natl. Acad. Sci. U.S.A., 93, 1753, 1996.
4. Thiemermann, C. et al., Inhibition of the activity of poly(ADP-ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle, Proc. Natl. Acad. Sci. U.S.A., 94, 679, 1997.
5. Banasik, M. and Ueda, K., Dual effects of dimethyl sulfoxide on poly(ADP-ribose) synthetase, J. Enzyme Inhibition, 14, 239, 1999.
6. Zingarelli, B. et al., Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthase, Cardiovasc. Res., 36, 205, 1997.
7. Bowes, J. et al., Reduction of myocardial reperfusion injury by an inhibitor of poly(ADP-ribose) synthetase in the pig, Eur. J. Pharmacol., 359, 143, 1998.
8. Docherty, J. C. et al., An inhibitor of poly(ADP-ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart, Br. J. Pharmacol., 127, 1518, 1999.
9. Neely, J. R. and Grotyohann, L. W., Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts, Circ. Res., 55, 816, 1984.
10. Rovetto, M. J., Energy metabolism in the ischemic heart, Texas Rep. Biol. Med., 39, 397, 1979.
11. Halmosi, R. et al., Effect of poly(ADP-ribose) polymerase inhibitors on the ischemiareperfusion- induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system, Mol. Pharmacol., 59, 1497, 2001.
12. Gilad, E. et al., Protection by inhibition of poly(ADP-ribose) synthetase against oxidant injury in cardiac myoblasts in vitro, J. Mol. Cell. Cardiol., 29, 2585, 1997.
13. Bowes, J. et al., Inhibitors of poly(ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress, Cardiovasc. Res., 41, 126, 1999.
14. Bowes, J., Piper, J., and Thiemermann, C., Inhibitors of the activity of poly(ADP-ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts, Br. J. Pharmacol., 124, 1760, 1998.
15. Zingarelli, B., Salzman, A. L., and Szabó, C., Genetic disruption of poly(ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia reperfusion injury, Circ. Res., 83, 94, 1998.
16. Yang, Z., Zingarelli, B. and Szabó, C., Effect of genetic disruption of poly(ADPribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion injury, Shock, 13, 60, 2000.
17. Pieper, A. A. et al., Myocardial postischemic injury is reduced by poly(ADP-ribose) polymerase-1 gene disruption, Mol. Med., 6(4), 271, 2000 (preliminary result published in abstract form).
18. Pieper, A. A. et al., Myocardial postischemic injury is reduced by polyADPribose polymerase-1 gene disruption, Mol. Med., 6, 271, 2000.
19. Grupp, I. L. et al., Protection against hypoxia-reoxygenation in the absence of poly(ADP-ribose) synthetase in isolated working hearts, J. Mol. Cell. Cardiol., 31, 297, 1999.
20. Stamler, J. S. and Meissner, G., Physiology of nitric oxide in skeletal muscle, Physiol. Rev., 81, 209, 2001.
21. Zhang, J. et al., Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity, Science, 263, 687, 1994.
22. Suto, M. J. et al., Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase, Anti-Cancer Drug Design, 6, 107, 1991.
23. Eliasson, M. J. et al., Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia, Nature Medicine, 10, 1089, 1997.
24. McDonald, M. C., Mota-Filipe, H., and Thiemermann, C., Effects of inhibitors of the activity of poly(ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock. Br. J. Pharmacol., 128, 1339, 1999.
25. Wray, G. M., Hinds, C., and Thiemermann, C., Effects of inhibitors of poly(ADPribose) synthetase activity on the hypotension and multiple organ dysfunction caused by endotoxin, Shock, 10, 13, 1998.
26. Wenkert, E., Johnston, D. B. R., and Dave, K. G., Derivatives of hemimellitic acid. A synthesis of erythrocentaurin, J. Org. Chem., 29, 2534, 1964.
27. Watson, C. Y., Whish, W. J. D., and Threadgill M. D., Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose) polymerase (PARP), Bioorg. Med. Chem., 6, 721, 1998.
28. Szabados, E. et al., BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase, Biochem. Pharmacol., 59, 937, 2000.
29. Cuzzocrea, S. et al., Beneficial effects of 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion, Br. J. Pharmacol., 121, 1065, 1997.
30. Endres, M. et al., Ischemic brain injury is mediated by the activation of poly(ADP-ribose) polymerase, J. Cereb. Blood Flow Metab., 17, 1143, 1997.
31. Chatterjee, P. K. et al., Inhibitors of poly(ADP-ribose) synthetase reduce renal ischemia- reperfusion injury in the anesthetized rat in vivo, FASEB J., 14, 641, 2000.
32. Smith, S., The world according to PARP, Trends Biochem. Sci., 26, 174, 2001.