Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxic shock: Potential involvement of polyADP ribosyl synthetase

Shock

Volumn 5, Issue 4, 1996, Pages 258-264

  Zingarelli, Basilia ^a   Salzman, Andrew L ^a   Szabó, Csaba ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NORADRENALIN;

ANIMAL; ARTICLE; BLOOD PRESSURE; DRUG ANTAGONISM; DRUG EFFECT; ENERGY METABOLISM; ENZYME ACTIVATION; HEART RATE; MACROPHAGE; MALE; METABOLISM; MITOCHONDRION; PATHOLOGY; RAT; SEPTIC SHOCK; VASCULAR RESISTANCE; WISTAR RAT;

ADP RIBOSE TRANSFERASES; ANIMALS; BLOOD PRESSURE; ENERGY METABOLISM; ENZYME ACTIVATION; HEART RATE; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MITOCHONDRIA; NAD; NIACINAMIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NOREPINEPHRINE; RATS; RATS, WISTAR; SHOCK, SEPTIC; VASCULAR RESISTANCE;

EID: 0030124761     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199604000-00005     Document Type: Article

References (35)

1. Nathan C: Nitric oxide as a secretory product of mammalian cells. FASEB J 6:3051-3064, 1992.
2. Xie Q, Nathan C: The high-output nitric oxide pathway: Role and regulation. J Leukocyte Biol 56:576-582, 1994.
3. Morris SM, Billiar TR: New insights into the regulation of inducible nitric oxide biosynthesis. Am J Physiol 266:E829-E839, 1994.
4. Kilboum RG, Griffith OW: Overproduction of nitric oxide in cytokine-mediated and septic shock. J Natl Cancer Inst 84:827-877, 1992.
5. Szabó C: Alterations in nitric oxide production in various forms of circulatory shock. New Horizons 3:2-32, 1995.
6. Thiemermann C, Wu CC, Szabó C, Perretti M, Vane JR: Tumour necrosis factor is an endogenous mediator of the induction of nitric oxide synthase in endotoxin shock in the rat. Br J Pharmacol 110:177-182, 1993.
7. Szabó C, Wu CC, Gross SS, Thiemermann C, Perretti M, Vane JR: Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo. Eur J Pharmacol 250:157-160, 1993.
8. Cetkovic-Cvrlje M, Sandler S, Eizirik DL: Nicotinamide and dexamethasone inhibit interleukin-1 induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase. Endocrinology 133:1739-1743, 1993.
9. Hauschildt S, Scheipers P, Bessler WG, Mulsch A: Induction of nitric oxide synthase in L929 cells by tumour-necrosis factor alpha is prevented by inhibitors of poly (ADP-ribose) polymerase. Biochem J 288:255-260, 1992.
10. Eizirik DL, Sandler S, Welsh N, Bendtzen K, Hellerstrom C: Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines. Autoimmunity 19:193-198, 1994.
11. Kallmann B, Burkart V, Kroncke KD, Kolb-Bachofen V, Kolb H: Toxicity of chemically generated nitric oxide towards pancreatic islet cells can be prevented by nicotinamide. Life Sci 51:671-678, 1992.
12. Radons J, Heller B, Burkle A, Hartmann B, Rodriguez ML: NO toxicity in islet cells involves polyADP-ribose-polymerase activation and concomitant NAD depletion. Biochem Biophys Res Commun 199:1270-1277, 1994.
13. Szabó C, Southan GJ, Thiemermann C: Beneficial effects and improved survival in rodent models of septic shock with S-methyl-isothiourea sulfate, a novel, potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci USA 91:12472-12476, 1994.
14. Hinz M, Katsilambros N, Maier V, Schatz H, Pfeiffer EF: Significance of streptozotocin-induced nicotinamide-adenine-dinucleotide (NAD) degradation in mouse pancreatic islets. FEBS Lett 30:225-231, 1973.
15. Zingarelli B, Caputi AP, Di Rosa M: Dexamethasone prevents vascular failure mediated by nitric oxide in hemorrhagic shock. Shock 2:210-215, 1994.
16. Wu CC, Szabó C, Chen SJ, Thiemermann C, Vane JR: Activation of soluble guanylyl cyclase by a factor other than nitric oxide or carbon monoxide contributes to the vascular hyporeactivity to vasoconstrictor agents in the aorta of rats treated with endotoxin. Biochem Biophys Res Commun 201:436-442, 1994.
17. Unno N, Menconi M, Smith M: Nitric oxide mediates interferon gamma induced hyperpermeability in cultured human intestinal epithelial monolayers. Crit Care Med 23:1170-1176, 1995.
18. G-monomethyl-L-arginine. J Cardiovasc Pharmacol 20(suppl 12):S132-S134, 1992.
19. Thiemermann C, Rutten H, Wu CC, Vane JR: The multiple organ dysfunction syndrome caused by endotoxin in the rat: Attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br J Pharmacol 116: 2845-2851, 1996.
20. Ungureanu-Longrois D, Balligand JL, Kelly R: Myocardial contractile dysfunction in the systemic inflammatory response syndrome: Role of a cytokine-inducible nitric oxide synthase in cardiac myocytes. J Mol Cell Cardiol 27:155-167, 1995.
21. Szabó C, Mitchell JA, Thiemermann C, Vane JR: Nitric oxide-mediated hyporeactivity to norepinephrine precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 108:786-792, 1993.
22. Southan GJ, Szabó C, Thiemermann C: Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br J Pharmacol 114:510-516, 1995.
23. Southan GJ, Zingarelli B, O'Connor M, Salzman AL, Szabó C: Spontaneous rearrangement of aminoalkylguanidines into mercaptoalkylguanidines: A novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br J Pharmacol 117:619-632, 1996.
24. Zhang J, Dawson VL, Dawson TM, Snyder SH: Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity. Science 263:687-689, 1994.
25. Cochrane CG: Mechanisms of oxidant injury of cells. Mol Aspects Med 12:137-147, 1991.
26. Zingarelli B, O'Connor M, Salzman AL, Szabó C: Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J Immunol 156:350-358, 1996.
27. Preiser JC, Lejeune P, Roman A: Methylene blue administration in septic shock: A clinical trial. Crit Care Med 23:259-264, 1995.
28. Szabó C, Zingarelli B, Salzman AL: Role of poly-ADP ribosyltransferase activation in the nitric oxide- and peroxynitrite-induced vascular failure. Circ Res 1996. In press.
29. Fleming I, Julou-Schaeffer G, Gray G: Evidence that an L-arginine/nitric oxide dependent elevation of tissue cyclic GMP content is involved in depression of vascular reactivity by endotoxin. Br J Pharmacol 103:1047-1052, 1991.
30. Marczin N, Ryan US, Catravas JD: Methylene blue inhibits nitrovasodilator- and endothelium-derived relaxing factor-induced cyclic GMP accumulation in cultured pulmonary arterial smooth muscle cells via generation of superoxide anion. J Pharmacol Exp Ther 263:170-179, 1992.
31. Geng Y, Hansson GK, Holme E: Interferon-γ and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells. Circ Res 71:1268-1276, 1992.
32. Szabó C, Salzman AL, Ischiropoulos H: Peroxynitrite-mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. FEBS Lett 372:229-232, 1995.
33. Szabó C, Zingarelli B, O'Connor M, Salzman AL: DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci USA 93:1753-1758, 1996.
34. Shaw RC, Holzer ME, Venzon D, Ullman R, Butcher HR, Moyer C: Effects of saline solution, ascorbic acid and nicotinamide upon the toxicity of endotoxin for rats. Arch Surg 93:562-566, 1966.
35. Wang ZQ, Auer B, Stingl L, et al: Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev 9:510-520, 1995.