GPI 6150, a poly (ADP-ribose) polymerase inhibitor, exhibits an anti-inflammatory effect in rat models of inflammation

European Journal of Pharmacology

Volumn 415, Issue 1, 2001, Pages 85-94

  Mazzon, Emanuela ^a   Serraino, Ivana ^a   Li, Jia He ^b   Dugo, Laura ^a   Caputi, Achille P ^a   Zhang, Jie ^b   Cuzzocrea, Salvatore ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

ADP ribose; Anti inflammatory; Polymerase

Indexed keywords

1,11B DIHYDRO [2H]BENZOPYRANO[4,3,2 DE]ISOQUINOLIN 3 ONE; ALANINE AMINOTRANSFERASE; BILIRUBIN; GLYCOSYLTRANSFERASE INHIBITOR; GPI 6150; LACTATE DEHYDROGENASE; MYELOPEROXIDASE; NITRIC OXIDE; OXYGEN RADICAL; PEROXYNITRITE; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL MODEL; ARTICLE; BILIRUBIN BLOOD LEVEL; CHRONIC INFLAMMATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; INFLAMMATION; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; MULTIPLE ORGAN FAILURE; NONHUMAN; PAW EDEMA; PERITONITIS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; BENZOPYRANS; CARRAGEENAN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; ENZYME INHIBITORS; HINDLIMB; INFLAMMATION; ISOQUINOLINES; LIVER; LUNG; MALE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, LONG-EVANS; SURVIVAL RATE; ZYMOSAN;

EID: 0035831143     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)00809-3     Document Type: Article

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