Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock

British Journal of Pharmacology

Volumn 130, Issue 4, 2000, Pages 843-850

  McDonald, Michelle C ^a   Mota Filipe, Helder ^a   Wright, James A ^b   Abdelrahman, Maha ^a   Threadgill, Michael D ^b   Thompson, Andrew S ^b   Thiemermann, Christoph ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b University of Bath   (United Kingdom)

Author keywords

5 Aminoisoquinolinone; Haemorrhagic shock; Multiple organ failure; Oxygen radicals; Poly (ADP ribose) synthetase; Trauma

Indexed keywords

5 AMINOISOQUINOLINONE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CELL ENZYME; CREATININE; ENZYME INHIBITOR; HYDROGEN PEROXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SYNTHETASE; UNCLASSIFIED DRUG; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD PRESSURE; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; CREATININE BLOOD LEVEL; DNA STRAND BREAKAGE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEART MUSCLE CELL; HEMORRHAGIC SHOCK; HUMAN; HUMAN CELL; LIVER INJURY; MALE; MITOCHONDRIAL RESPIRATION; MULTIPLE ORGAN FAILURE; NEUROMUSCULAR DISEASE; NONHUMAN; PANCREAS INJURY; PRIORITY JOURNAL; RAT; RESUSCITATION; UREA BLOOD LEVEL;

EID: 0034124755     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703391     Document Type: Article

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