A pore-lining glutamic acid in the rat olfactory cyclic nucleotide-gated channel controls external spermine block

Neuroscience Letters

Volumn 296, Issue 2-3, 2000, Pages 163-167

  Nevin, Simon T ^a   Haddrill, Justine L ^a   Lynch, Joseph W ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Binding site; Cyclic adenosine monophosphate; Cyclic nucleotide gated channel; Olfactory; Polyamine; Spermine

Indexed keywords

CYCLIC NUCLEOTIDE; GLUTAMIC ACID; PROTEIN SUBUNIT; SPERMINE;

AMINO ACID SUBSTITUTION; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; MEMBRANE CHANNEL; NONHUMAN; OLFACTORY RECEPTOR; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; HUMANS; ION CHANNELS; MEMBRANE POTENTIALS; MUTATION; OLFACTORY RECEPTOR NEURONS; PROTEIN STRUCTURE, TERTIARY; RATS; SPERMINE;

EID: 0034704359     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01650-5     Document Type: Article

References (19)

1. Single-channel properties of ionic channels gated by cyclic nucleotides
2. Blockage and permeation of divalent cations through the cyclic GMP-activated channel from tiger salamander retinal rods
3. Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons
4. 2+ permeation in cyclic nucleotide-gated channels
5. 2+ blockage and ionic selectivity
6. Tetracaine reports a conformational change in the pore of cyclic nucleotide-gated channels
7. Profoundly different calcium permeation and blockage determine specific function of distinct cyclic nucleotide-gated channels
8. 2+ blockage and permeation of olfactory cyclic nucleotide-gated channels
9. Mechanism of cGMP-gated channel block by intracellular polyamines
10. Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells
11. Blockade of a retinal cGMP-gated channel by polyamines
12. Rectification of the olfactory cyclic nucleotide-gated channel by intracellular polyamines
13. Divalent cation selectivity in a cyclic nucleotide-gated channel
14. Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel
15. 2+-binding site in the pore of cyclic nucleotide-gated channels: S5/S6 segments control affinity of intrapore glutamates
16. Ionic blockage of sodium channels in nerve
17. Interactions of polyamines with ion channels
18. Cation interactions within the cyclic GMP-activated channel of retinal rods from tiger salamander
19. Divalent cations block the cyclic nucleotide-gated channel of olfactory receptor neurons