Ultrasensitive pheromone detection by mammalian vomeronasal neurons

Nature

Volumn 405, Issue 6788, 2000, Pages 792-796

  Leinders Zufall, Trese ^a   Lane, Andrew P ^a   Puche, Adam C ^a   Ma, Weldong ^b   Novotny, Milos V ^b   Shipley, Michael T ^a   Zufall, Frank ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHEROMONE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CHEMORECEPTOR; ELECTROPHYSIOLOGY; FEMALE; IMAGING; MAMMAL; MOUSE; NONHUMAN; OLFACTORY NERVOUS SYSTEM; PRIORITY JOURNAL; SEXUAL BEHAVIOR; VOMERONASAL ORGAN;

ANIMALS; CALCIUM; ELECTROPHYSIOLOGY; FEMALE; LIGANDS; MALE; MICE; MICROSCOPY, CONFOCAL; OLFACTORY RECEPTOR NEURONS; PHEROMONES; SIGNAL TRANSDUCTION; VOMERONASAL ORGAN;

EID: 0034660119     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35015572     Document Type: Article

References (30)

1. Halpern, M. The organization and function of the vomeronasal system. Annu. Rev. Neurosci. 10, 325-362 (1987).
2. Wysocki, C. J. & Meredith, M. in Neurobiology of Taste and Smell (eds Finger, T. E. & Silver, W. L.) 125-150 (Wiley & Sons, New York, 1987).
3. Keverne, E. B. The vomeronasal organ. Science 286, 716-723 (1999).
4. Bargmann, C. I. Olfactory receptors, vomeronasal receptors, and the organization of olfactory information. Cell 90, 585-587 (1997).
5. Tirindelli, R., Mucignat-Caretta, C. & Ryba, N. J. P. Molecular aspects of pheromonal communication via the vomeronasal organ of mammals. Trends Neurosci. 21, 482-486 (1998).
6. Novotny, M. V., Jemiolo, B., Harvey, S., Wiesler, D. & Marchlewska-Koj, A. Adrenal-mediated endogenous metabolites inhibit puberty in female mice. Science 231, 722-725 (1986).
7. Jemiolo, B., Harvey, S. & Novotny, M. V. Promotion of the Whitten effect in female mice by synthetic analogs of male urinary constituents. Proc. Natl Acad. Sci. USA 83, 4576-4579 (1986).
8. Novotny, M. V., Ma, W., Wiesler, D. & Zidek, L. Positive identification of the puberty-accelerating pheromone of the house mouse: the volatiles associating with the major urinary protein. Proc. R. Soc. Lond. R 266, 2017-2022 (1999).
9. Jemiolo, B., Andreolini, F., Xie, T.-M., Wiesler, D. & Novotny, M. V. Puberty-affecting synthetic analogs of urinary chemosignals in the house mouse, Mus domesticus. Physiol. Behav. 46, 293-298 (1989).
10. Novotny, M. V. et al. A unique urinary constituent, 6-hydroxy-6-methyl-3-heptanone, is a pheromone that accelerates puberty in female mice. Chem. Biol. 6, 377-383 (1999).
11. Inamura, K., Kashiwayanagi, M. & Kurihara, K. Inositol-1,4,5-triphosphate induces responses in receptor neurons in rat vomeronasal sensory slices. Chem. Senses 22, 93-103 (1997).
12. 2+ gradients in rat olfactory neurons. J. Gen. Physiol. 102, 907-924 (1993).
13. Bozza, T. C. & Kauer, J. S. Odorant response properties of convergent olfactory receptor neurons. J. Neurosci. 18, 4560-4569 (1998).
14. Leinders-Zufall, T., Greer, C. A., Shepherd, G. M. & Zufall, F. Imaging odor-induced calcium transients in single olfactory cilia: specificity of activation and role in transduction. J. Neurosci. 18, 5630-5639 (1998).
15. Dulac, C. & Axel, R. A novel family of genes encoding putative pheromone receptors in mammals. Cell 83, 195-206 (1995).
16. Herrada, G. & Dulac, C. A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. Cell 90, 763-773 (1997).
17. Matsunami, I. & Buck, L. B. A multigene family encoding a diverse array of putative pheromone receptors in mammals. Cell 90, 775-784 (1997).
18. Ryba, N. J. P. & Tirindelli, R. A new multigene family of putative pheromone receptors. Neuron 19, 371-379 (1997).
19. Jia, C. & Halpern, M. Subclasses of vomeronasal receptor neurons: differential expression of G protein (Giα2 and Goα) and segregated projections to the accessory olfactory bulb. Brain Res. 719, 117-128 (1996).
20. 0,2, and adenylyl cyclase II as major components of a pheromone signaling cascade. J. Neurosci. 16, 909-918 (1996).
21. Kauer, J. S. Contributions of topography and parallel processing to odor coding in the vertebrate olfactory pathway. Trends Neurosci. 14, 79-85 (1991).
22. Mori, K. & Yoshihara, Y. Molecular recognition and olfactory processing in the mammalian olfactory system. Prog. Neurobiol. 45, 585-620 (1995).
23. Duchamp-Viret, P., Chaput, M. A. & Duchamp, A. Odor response properties of rat olfactory receptor neurons. Science 284, 2171-2174 (1999).
24. Malnic, B., Hirono, J., Sato, T. & Buck, L. B. Combinatorial receptor codes for odors. Cell 96, 713-723 (1999).
25. Hildebrand, J. G. & Shepherd, G. M. Mechanisms of olfactory discrimination: converging evidence for common principles across phyla. Annu. Rev. Neurosci. 20, 595-631 (1997).
26. Zidek, L., Joo, A., Ma, W., Miao, Z. & Novotny, M. V. 4,5-dihydrothiazoles exhibit no correlations between their puberty-acceleration and activity for soluble binding proteins in the house mouse. Chem. Senses (submitted).
27. Rodriguez, I., Feinstein, P. & Mombaerts, P. Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system. Cell 97, 199-208 (1999).
28. Belluscio, L., Koentges, G., Axel, R. & Dulac, C. A map of pheromone receptor activation in the mammalian brain. Cell 97, 209-220 (1999).
29. Leinders-Zufall, T., Rand, M. N., Shepherd, G. M., Greer, C. A. & Zufall, F. Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: spatiotemporal dynamics. J. Neurosci. 17, 4136-4148 (1997).
30. Novotny, M., Schwende, F. J., Wiesler, D., Jorgenson, J. W. & Carmack, M. Identification of a testosterone-dependent unique volatile constituent of male mouse urine: 7-exo-ethyl-5-methyl-6,8-dioxabicyclo[3.2.1]-3-octene. Experientia 40, 217-219 (1984).