Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: Spatiotemporal dynamics

Journal of Neuroscience

Volumn 17, Issue 11, 1997, Pages 4136-4148

  Leinders Zufall, Trese ^a   Rand, Mark N ^a,b   Shepherd, Gordon M ^a   Greer, Charles A ^a   Zufall, Frank ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

calcium signaling; cAMP; cGMP; cilia; confocal microscopy; cyclic nucleotide gated channels; G protein coupled second messenger pathways; imaging; olfactory receptor neurons; salamander; sensory adaptation

Indexed keywords

CALCIUM; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; FLUORESCENT DYE; GUANINE NUCLEOTIDE BINDING PROTEIN;

ADAPTATION; ADOLESCENT; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CHANNEL GATING; CONFOCAL MICROSCOPY; FLUORESCENCE ANALYSIS; NONHUMAN; OLFACTORY EPITHELIUM; OLFACTORY RECEPTOR; PRIORITY JOURNAL; SALAMANDER; SECOND MESSENGER; SIGNAL TRANSDUCTION;

EID: 0030941766     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-11-04136.1997     Document Type: Article

References (19)

1. Ahmad I, Leinders-Zufall T, Kocsis JD, Shepherd GM, Zufall F, Barnstable CJ (1994) Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron 12:155-165.
2. Anderson PAV, Hamilton KA (1987) Intracellular recordings from isolated salamander olfactory receptor neurons. Neuroscience 21:167-173.
3. Anholt RRH, Rivers AM (1990) Olfactory transduction: cross-talk between second-messenger systems. Biochemistry 29:4049-4054.
4. Borisy FF, Ronnett GV, Cunningham AM, Julif D, Beavo J, Snyder SH (1992) Calcium/calmodulin-activated phosphodiesterase expressed in olfactory receptor neurons. J Neurosci 12:915-923.
5. Bradley J, Zhang Y, Bakin R, Lester HA, Ronnett GV, Zinn K (1997) Functional expression of the heteromeric "olfactory" cyclic nucleotidegated channel in the hippocampus: a potential effector of synaptic plasticity in brain neurons. J Neurosci 17:1993-2005.
6. Breer H (1993) Second messenger signalling in olfaction. In: Ciba Foundation Symposium 179. The molecular basis of smell and taste transduction, pp 97-114. Chichester, UK: Wiley.
7. Breer H, Klemm T, Boekhoff I (1992) Nitric oxide-mediated formation of cyclic GMP in the olfactory system. NeuroReport 3:1030-1032.
8. Brunet LJ, Gold GH, Ngai J (1996) General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron 17:681-693.
9. 2+-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature 368:545-548.
10. Firestein S, Werblin F (1989) Odor-induced membrane currents in vertebrate olfactory receptor neurons. Science 244:79-82.
11. Firestein S, Darrow B, Shepherd GM (1991a) Activation of the sensory current in salamander olfactory receptor neurons depends on a G-protein-mediated cAMP second messenger system. Neuron 6:825-835.
12. Firestein S, Zufall F, Shepherd GM (1991b) Single odor-sensitive chan-nels in olfactory receptor neurons are also gated by cyclic nucleotides. J Neurosci 11:3565-3572.
13. Frings S, Lynch JW, Lindemann B (1992) Properties of cyclic nucleotide-gated channels mediating olfactory transduction. J Gen Physiol 100:45-67.
14. Frings S, Seifert R, Godde M, Kaupp UB (1995) Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels. Neuron 15:169-179.
15. 3-sensitive calcium stores in salamander olfactory receptor neurons. Chem Senses 21:A609.
16. Ingi T, Ronnett GV (1995) Direct demonstration of a physiological role for carbon monoxide in olfactory receptor neurons. J Neurosci 15:8214-8222.
17. Jaworsky DE, Matsuzaki O, Borisy FF, Ronnett GV (1995) Calcium modulates the rapid kinetics of the odorant-induced cyclic AMP signal in rat olfactory cilia. J Neurosci 15:310-318.
18. Jung A, Lischka FW, Engel J, Schild D (1994) Sodium/calcium exchanger in olfactory receptor neurones of Xenopus laevis. NeuroReport 5:1741-1744.
19. Kao JPY, Harootunian AT, Tsien RY (1989) Photochemically generated cytosolic calcium pulses and their detection by Fluo-3. J Biol Chem 264:8179-8184.