A depolarizing chloride current contributes to chemoelectrical transduction in olfactory sensory neurons in situ

Journal of Neuroscience

Volumn 18, Issue 17, 1998, Pages 6623-6630

  Reuter, Dirk ^a   Zierold, Karl ^b   Schröder, Walter H ^a   Frings, Stephan ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

Chloride channels; Chloride concentration; EDX microanalysis; Mucus; Olfaction; Olfactory sensory neurons; Receptor current; Sensory transduction

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CHLORIDE CURRENT; DEPOLARIZATION; MICROANALYSIS; NONHUMAN; OLFACTORY NERVOUS SYSTEM; PRIORITY JOURNAL; PSEUDOPODIUM; RAT; SENSORY NERVE CELL; TRANSMISSION ELECTRON MICROSCOPY; X RAY MICROANALYSIS;

EID: 0032171171     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-17-06623.1998     Document Type: Article

References (26)

1. Bakalyar HA, Reed RR (1990) Identification of a specialized adenylyl cyclase that may mediate odorant detection. Science 250:1403-1406.
2. Barbi NC (1979) Quantitative methods in biological x-ray microanalysis. Scanning Electron Microsc 2:659-672.
3. Boekhoff I, Tareilus E, Strotmann J, Breer H (1990) Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants. EMBO J 9:2453-2458.
4. Borisy FF, Ronnett GV, Cunningham D, Juilfs D, Beavo J, Snyder SH (1992) Calcium/calmodulin-activated phosphodiesterase expressed in olfactory receptor neurons. J Neurosci 12:915-923.
5. Breer H, Wanner I, Strotmann J (1996) Molecular genetics of mammalian olfaction. Behav Genet 26:209-219.
6. Bronshtein AA, Leont'ev VG (1972) The sodium and potassium content of the mucus of the olfactory epithelium of vertebrates. J Evol Biochem Physiol 8:520-524.
7. Buck LB (1996) Information coding in the vertebrate olfactory system. Annu Rev Neurosci 19:517-544.
8. 2+-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature 368:545-548.
9. Cherubini E, Gaiarsa JL, Ben-Ari Y (1991) GABA: an excitatory transmitter in early postnatal life. Trends Neurosci 14:515-519.
10. Chiu D, Nakamura T, Gold GH (1989) Ionic composition of toad olfactory mucus measured with ion selective microelectrodes. Chem Senses 13:677-678.
11. Davson H, Segal MB (1975) Introduction to physiology. New York: Academic.
12. Dubin AE, Dionne VE (1994) Action potentials and chemosensitive conductances in the dendrites of olfactory neurons suggest new features for odor transduction. J Gen Physiol 103:181-201.
13. Fain GL, Schröder WH (1985) Calcium content and calcium exchange in dark-adapted toad rods. J Physiol (Lond) 368:641-665.
14. Firestein S, Shepherd GM (1995) Interaction of anionic and cationic currents leads to a voltage dependence in the odor response of olfactory receptor neurons. J Neurophysiol 73:562-567.
15. Firestein S, Werblin FS (1987) Gated currents in isolated olfactory receptor neurons of the larval tiger salamander. Proc Natl Acad Sci USA 84:6292-6296.
16. Frings S, Lindemann B (1988) Odorant response of isolated olfactory receptor cells is blocked by amiloride. J Membr Biol 105:233-243.
17. 2+ ions. J Gen Physiol 97:725-747.
18. Frings S, Seifert F, Godde M, Kaupp UB (1995) Profoundly different calcium permeation and blockage determine the specific function of distinct cyclic nucleotide-gated channels. Neuron 15:169-179.
19. Getchell TV, Margolis FL, Getchell ML (1984) Perireceptor and receptor events in vertebrate olfaction. Prog Neurobiol 23:317-345.
20. Getchell ML, Zielinski B, Getchell TV (1988) Odorant and autonomic regulation of secretion in the olfactory mucosa. In: Molecular neurobiology of the olfactory system (Margolis FL, Getchell TV, eds), pp 71-98. New York: Plenum.
21. Hallani M, Lynch JW, Barry PH (1998) Characterization of calcium-activated chloride channels in patches excised from the dendritic knob of mammalian olfactory receptor neurons. J Membr Biol 161:163-171.
22. Hedlund B, Masukawa LM, Shepherd GM (1987) Excitable properties of olfactory receptor neurons. J Neurosci 7:2338-2343.
23. Hentschel H, Zierold K (1994) Morphology and element distribution of magnesium-secreting epithelium: the proximal tubule segment PII of dogfish, Scyliorhinus caniculus (L.) Eur J Cell Biol 63:32-42.
24. Joshi H, Getchell ML, Zielinski B, Getchell TV (1987) Spectrophotometric determination of cation concentrations in olfactory mucus. Neurosci Lett 82:321-326.
25. Kerjaschki D, Hörandner H (1976) The development of mouse olfactory vesicles and their cell contacts. J Ultrastruct Res 54:420-444.
26. Kleene SJ (1993) Origin of chloride current in olfactory transduction. Neuron 11:123-132.