Ligand sensitivity of the α2 subunit from the bovine cone cGMP-gated channel is modulated by protein kinase C but not by calmodulin

Journal of Physiology

Volumn 532, Issue 2, 2001, Pages 399-409

  Müller, Frank ^a   Vantler, Marius ^b   Weitz, Dietmar ^b   Eismann, Elisabeth ^b   Zoche, Martin ^b   Koch, Karl Wilhelm ^a   Benjamin Kaupp, U ^b  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CALCIUM; CALMODULIN; CYCLIC GMP; ISOENZYME; LIGAND; PROTEIN KINASE C; PROTEIN SUBUNIT; SERINE; CYCLIC GMP GATED CHANNEL ALPHA 2; CYCLIC NUCLEOTIDE GATED CHANNEL; GUANYLATE CYCLASE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG; CYCLIC NUCLEOTIDE GATED ION CHANNELS; CYCLIC-NUCLEOTIDE GATED ION CHANNELS; ION CHANNEL; ISOPROTEIN; PEPTIDE FRAGMENT; PHORBOL 13 ACETATE 12 MYRISTATE; PRKCD PROTEIN, HUMAN; PRKCD PROTEIN, RAT; PROTEIN KINASE C DELTA;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIBODY LABELING; ANTIBODY SPECIFICITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL LINE; CHANNEL GATING; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MUTANT; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RETINA CONE; ADULT; ANIMAL TISSUE; CONFOCAL LASER MICROSCOPY; MEMBRANE POTENTIAL; NONHUMAN; PHOTOSENSITIVITY; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN MOTIF; RAT; RESTRICTION SITE; SENSITIVITY ANALYSIS; STOICHIOMETRY; SURFACE PLASMON RESONANCE; AMINO ACID SEQUENCE; ANIMAL; BINDING COMPETITION; CATTLE; DRUG EFFECT; GENETICS; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CALCIUM; CALMODULIN; CATTLE; CELL LINE; CONES (RETINA); CYCLIC GMP; HUMANS; ION CHANNELS; ISOENZYMES; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; RATS; TETRADECANOYLPHORBOL ACETATE;

EID: 0035870097     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2001.0399f.x     Document Type: Article

References (52)

1. Calcium-dependent modulation of the agonist affinity of the mammalian olfactory cyclic nucleotide-gated channel by calmodulin and a novel endogenous factor
2. 2+-calmodulin binding sites
3. Primary structure and functional expression of a Drosophila cyclic nucleotide-gated channel present in eyes and antennae
4. Molecular cloning and expression of a modulatory subunit of the cyclic nucleotide-gated cation channel
5. Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels
6. The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits
7. Two alternatively spliced forms of the cGMP-gated channel α-subunit from cone photoreceptor are expressed in the chick pineal organ
8. Heteromeric olfactory cyclic nucleotide-gated channels: A new subunit that confers increased sensitivity to cAMP
9. 2+-calmodulin modulation
10. A novel subunit of the cyclic nucleotide-gated cation channel in retinal rods
11. 2+-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons
12. Human rod photoreceptor cGMP-gated channel: Amino acid sequence, gene structure, and functional expression
13. Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons
14. Cyclic nucleotide-gated ion channels: An extended family with diverse functions
15. Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina
16. Protein phosphatases modulate the apparent agonist affinity of the light-regulated ion channel in retinal rods
17. Modulation of the cGMP-gated ion channel in frog rods by calmodulin and an endogenous inhibitory factor
18. A histidine residue associated with the gate of the cyclic nucleotide-activated channels in rod photoreceptors
19. Molecular mechanism of cyclic-nucleotide-gated channel activation
20. Identification of a domain on the β-subunit of the rod cGMP-gated cation channel that mediates inhibition by calcium-calmodulin
21. Molecular determinants of the modulation of cyclic nucleotide-activated channels by calmodulin
22. Calcium modulation of ligand affinity in the cyclic GMP-gated ion channels of cone photoreceptors
23. Modulation of rod, but not cone, cGMP-gated photoreceptor channels by calcium-calmodulin
24. A general and rapid mutagenesis method using polymerase chain reaction
25. Modulation of the cGMP-gated channel of rod photoreceptor cells by calmodulin
26. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel
27. Ligand-protein binding affinities
28. Identification and characterization of calmodulin binding sites in cGMP-gated channel using surface plasmon resonance spectroscopy
29. 2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells
30. A 240 kDa protein represents the complete β subunit of the cyclic nucleotide-gated channel from rod photoreceptor
31. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
32. Mechanism of odorant adaptation in the olfactory receptor cell
33. A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP
34. Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel
35. Primary structure of cAMP-gated channel from bovine olfactory epithelium
36. Noncatalytic inhibition of cyclic nucleotide-gated channels by tyrosine kinase induced by genistein
37. Modulation of rod photoreceptor cyclic nucleotide-gated channels by tyrosine phosphorylation
38. Phosphorylation of mammalian olfactory cyclic nucleotide-gated channels increases ligand sensitivity
39. Studies and perspectives of protein kinase C
40. Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel
41. 2+-dependent, diffusible factor modulates the cGMP-gated ion channels differently than in rods
42. An isoform of the rod photoreceptor cyclic nucleotide-gated channel β subunit expressed in olfactory neurons
43. Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin
44. Interdomain interactions underlying activation of cyclic nucleotide-gated channels
45. Calmodulin controls the rod photoreceptor CNG channel through an unconventional binding site in the N-terminus of the β-subunit
46. Cloning and functional expression of a cyclic-nucleotide-gated channel from mammalian sperm
47. 2+ entry into sperm
48. Cloning, chromosomal localization and functional expression of the gene encoding the α-subunit of the cGMP-gated channel in human cone photoreceptors
49. Protein kinase C activity and light sensitivity of single amphibian rods
50. Molecular cloning, functional expression and chromosomal localization of a human homolog of the cyclic nucleotide-gated ion channel of retinal cone photoreceptor
51. Distinct molecular recognition of calmodulin-binding sites in the neuronal and macrophage nitric oxide synthases: A surface plasmon resonance study
52. Three amino acids in the C-linker are major determinants of gating in cyclic nucleotide-gated channels