Opening mechanism of a cyclic nucleotide-gated channel based on analysis of single channels locked in each liganded state

Journal of General Physiology

Volumn 113, Issue 6, 1999, Pages 873-895

  Ruiz, MariaLuisa ^a   Karpen, Jeffrey W ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Allosteric proteins; Ligand gated ion channels; Patch clamp; Photoaffinity labeling; Retinal rod photoreceptors

Indexed keywords

CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CHANNEL GATING; CHEMICAL REACTION KINETICS; CONDUCTANCE; CONFORMATIONAL TRANSITION; LIGAND BINDING; MODEL; NONHUMAN; PATCH CLAMP; PHOTOAFFINITY LABELING; PHOTORECEPTOR; RETINA ROD; XENOPUS LAEVIS;

AFFINITY LABELS; ALLOSTERIC REGULATION; ANIMALS; AZIDES; CATTLE; CYCLIC AMP; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC CONDUCTIVITY; ION CHANNEL GATING; ION CHANNELS; LIGANDS; MEMBRANE POTENTIALS; MODELS, CHEMICAL; OOCYTES; PATCH-CLAMP TECHNIQUES; RODS (RETINA); XENOPUS LAEVIS;

EID: 0033042260     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.113.6.873     Document Type: Article

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