Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action

Journal of Neuroscience

Volumn 16, Issue 4, 1996, Pages 1285-1293

  Kramer, Richard H ^a   Tibbs, Gareth R ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b The New York Presbyterian Hospital   (United States)

Author keywords

cAMP; cGMP; cyclic nucleotide binding proteins; ligand gated channels; olfactory neurons; photoreceptors

Indexed keywords

CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; PHOSPHOROTHIOIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATFISH; CHANNEL GATING; LIGAND BINDING; MEMBRANE PERMEABILITY; MOLECULAR DYNAMICS; NONHUMAN; OLFACTORY EPITHELIUM; OLFACTORY RECEPTOR; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN BINDING; RECEPTOR BLOCKING;

EID: 0029916901     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-04-01285.1996     Document Type: Article

References (32)

1. Ahmad I, Leinders-Zufall T, Kocsis JD, Shepherd GM, Zufall F, Barnstable CJ (1994) Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron 12:155-165.
2. Altenhofen W, Ludwig J, Eismann E, Kraus W, Bonigk W, Kaupp UB (1991) Control of ligand specificity in cyclic nucleotide-gated channels from rod photoreceptors and olfactory epithelium. Proc Natl Acad Sci USA 88:9868-9872.
3. Biel M, Zong X, Distler M, Bosse E, Klugbauer N, Murakami M, Flockerzi V, Hofmann F (1994) Another member of the cyclic nucleotide-gated channel family expressed in testis, kidney, and heart. Proc Natl Acad Sci USA 91:3505-3509.
4. Botelho LHP, Rothermael JD, Coombs RV, Jastorff B (1988) cAMP analog antagonists of cAMP action. Methods Enzymol 159:159-172.
5. Bradley J, Li J, Davidson N, Lester HA, Zinn K (1994) Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proc Natl Acad Sci USA 91:8890-8894.
6. Brown RL, Bert RJ, Evans FE, Karpen JW (1993) Activation of retinal rod cGMP-gated channels: what makes for an effective 8-substituted derivative of cGMP? Biochemistry 32:10089-10095.
7. Butt E, Van Bemmelen M, Fischer L, Walter U, Jastorff B (1990) Inhibition of cGMP-dependent protein kinase by Rp-guanosine 3′,5′-monophosphorothioate. FEBS Lett 263:47-50.
8. Chen T-Y, Peng Y-W, Dhallan RS, Ahamed B, Reed RR, Yau K-W (1993) A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature 362:764-767.
9. Dhallan RS, Yau K-W, Schrader K, Reed R (1990) Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature 347:184-187.
10. DiFrancesco D, Tortora P (1991) Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature 351:145-147.
11. p)-cAMPS functions as an antagonist in the activation of cAMP-dependent protein kinase I. Biochemistry 30:8710-8716.
12. Fesenko EE, Kolesnikov SS, Lyubarsky AL (1985) Induction by cyclic GMP of a cationic conductance in plasma membrane of retinal rod outer segment. Nature 313:310-313
13. Furman RE, Tanaka JC (1989) Photoreceptor channel activation: interaction between cAMP and cGMP. Biochemistry 28:2785-2788.
14. Gordon SE, Zagotta WN (1995a) A histidine associated with the gate of the cyclic nucleotide-activated channels in rod photoreceptors. Neuron 14:177-183.
15. Gordon SE, Zagotta WN (1995b) Localization of regions affecting an allosteric transition in cyclic nucleotide-activated channels. Neuron 14:857-864.
16. Gordon SE, Brautigan DL, Zimmerman AL (1992) Protein phosphatases modulate the apparent agonist affinity of the light-regulated ion channel in retinal rods. Neuron 9:739-748.
17. Goulding EH, Ngai J, Kramer RH, Colicos S, Axel R, Siegelbaum SA, Chess A (1992) Molecular cloning and single channel properties of the cyclic nucleotide-gated channel from catfish olfactory neurons. Neuron 8:45-58.
18. Goulding EH, Tibbs G, Siegelbaum SA (1994) Molecular mechanism of cyclic-nucleotide-gated channel activation. Nature 372:369-374.
19. Kaupp BU, Niidome T, Tanabe T, Terada S, Bonigk W, Stuhmer W, Cook NJ, Kangawa K, Matsuo H, Hirode T, Miyata T, Numa S (1989) Primary structure and functional expression from complementary DNA of the rod photoreceptor cGMP-gated channel. Nature 342:762-766.
20. 2+ regulates the sensitivity of cyclic nucleotide-gated channels in olfactory receptor neurons. Neuron 9:897-906.
21. Liman ER, Buck LB (1994) A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron 13:611-621.
22. Matthews G, Watanabe S (1987) Properties of ion channels closed by light and opened by guanosine 3′,5′-cyclic monophosphate in toad retinal rods. J Physiol (Lond) 389:691-715.
23. Nakamura T, Gold GH (1987) A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature 325:442-444.
24. Nawy S, Jahr CE (1991) cGMP-gated conductance in retinal bipolar cells is suppressed by the photoreceptor neurotransmitter. Neuron 7:677-683.
25. Scholubbers HG, van Knippenburg PH, Baraniak J, Stec WJ, Morr M, Jastorff B (1984) Investigations on stimulation of lac transcription in vivo in Escherichia coli by cAMP analogues: biological activities and structure-activity correlations. Eur J Biochem 138:101-109.
26. Shabb JM, Corbin JD (1992) Cyclic nucleotide-binding domains in proteins having diverse functions. J Biol Chem 267:5723-5726.
27. Weber IT, Steitz TA (1987) Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 Å resolution. J Mol Biol 198:311-326.
28. Weber IT, Shabb JB, Corbin JD (1989) Predicted structure of the cGMP binding domains of the cGMP-dependent protein kinases: a key alanine/threonine difference in evolutionary divergence of cAMP and cGMP binding sites. Biochemistry 28:6122-6127.
29. Weyand I, Godde M, Frings S, Weiner J, Muller F, Altenhofen W, Hatt H, Kaupp UB (1994) Cloning and functional expression of a cyclic nucleotide-gated channel from mammalian sperm. Nature 368:859-863.
30. Yau K-W (1994) Cyclic nucleotide-gated channels: an expanding new family of ion channels. Proc Natl Acad Sci USA 91:3481-3483
31. Zimmerman AL, Yamanaka G, Eckstein F, Baylor DA, Stryer L (1985) Interaction of hydrolysis-resistant analogs of cyclic GMP with the phosphodiesterase and light-sensitive channel of retinal rod outer segments. Proc Natl Acad Sci USA 82:8813-8817.
32. Zimmerman AL, Karpen JW, Baylor DA (1988) Hindered diffusion in excised patches from retinal rod outer segments. Biophys J 54:351-355.