Cyclic nucleotide-gated channels: Structural basis of ligand efficacy and allosteric modulation

Quarterly Reviews of Biophysics

Volumn 30, Issue 2, 1997, Pages 177-193

  Li, Jun ^a   Zagotta, William N ^b   Lester, Henry A ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALMODULIN; METAL ION; NUCLEOTIDE; PROTON; THIOL GROUP;

ALLOSTERISM; CHANNEL GATING; CONFERENCE PAPER; HUMAN; LIGAND BINDING; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE;

ALLOSTERIC REGULATION; ANIMALS; CALCIUM; CALMODULIN; CYCLIC AMP; CYCLIC GMP; ION CHANNEL GATING; ION CHANNELS; LIGANDS; MODELS, STRUCTURAL; PHOSPHORYLATION;

EID: 0030967839     PISSN: 00335835     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0033583597003326     Document Type: Conference Paper

References (62)

1. ALTENHOFEN, W., LUDWIG, J., EISMANN, E., KRAUS, W., BÖNIGK, W. & KAUPP, U. B. (1991). Control of ligand specificity in cyclic nucleotide-gated channels from rod photoreceptors and olfactory epithelium. Proc. Natl. Acad. Sci. USA 88, 9868-9872.
2. BOTELHO, L., ROTHERMAEL, J., COOMBS, R. & JASTORFF, B. (1988). cAMP analog antagonists of cAMP action. Meth. Enzym. 159, 159-172.
3. BRADLEY, J., LI, J., DAVIDSON, N., LESTER, H. A. & ZINN, K. (1994). Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proc. Natl. Acad. Sci. USA 91, 8890-8894.
4. BROILLET, M.-C. & FIRESTEIN, S. (1996a). Direct activation of the olfactory cyclic nucleotide-gated channel through modification of sulfhydryl groups by NO compounds. Neuron 16, 377-385.
5. BROILLET, M.-C. & FIRESTEIN, S. (1996b). Homomeric cyclic nucleotide-gated channels formed by cloned rat olfactory subunit 2 are gated by nitric oxide. Abstracts of Society for Neuroscience 22, 651.
6. p)-guanosine 3′,5′-monophosphorothioates. FEBS Lett. 263, 47-50.
7. CHANGEUX, J.-P. (1995). The acetylcholine receptor: a model for allosteric membrane proteins. Biochem. Soc. Trans. 23, 195-205.
8. CHANGEUX, J.-P., THIÉRY, J., TUNG, Y. & KITTEL, C. (1967). On the cooperativity of biological membranes. Proc. Natl. Acad. Sci. USA 57, 335-341.
9. 2+-calmodulin modulation. Proc. Natl. Acad. Sci. USA 91, 11757-11761.
10. CHEN, T.-Y., PENG, V. W., DHALLAN, R. S., AHAMED, B., REED, R. R. & YAU, K.-W. (1993). A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature (London) 362, 764-767.
11. 2+-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature (London) 368, 545-548.
12. COLQUHOUN, D. (1973). The relation between classical and cooperative models for drug action. In Drug Receptors (ed. H. P. Rang), pp. 149-182. New York: MacMillan.
13. DEL CASTILLO, J. & KATZ, B. (1957). Interaction at end-plate receptors between different choline derivatives. Proc. R. Soc. London Ser. B 146, 369-381.
14. p)-CAMPs functions as an antagonist in the activation of cAMP-dependent protein kinase 1. Biochemistry 30, 8710-8716.
15. FESENKO, E. E., KOLESNIKOV, S. S. & LYUBARSKY, A. L. (1985). Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment. Nature (London) 313, 310-313.
16. FINN, J. T., GRUNWALD, M. E. & YAU, K.-W. (1996). Cyclic nucleotide-gated ion channels: an extended family with diverse functions. Annu. Rev. Physiol. 58, 395-426.
17. GALZI, J.-L. & CHANGEUX, J.-P. (1994). Neurotransmitter-gated ion channels as unconventional allosteric proteins. Curr. Opin. Struc. Biol. 4, 554-565.
18. GALZI, J.-L., EDELSTEIN, S. & CHANGEUX, J.-P. (1996). The multiple phenotypes of allosteric receptor mutants. Proc. Natl. Acad. Sci. USA 93, 1853-1858.
19. GORDON, S., BRAUTIGAN, D. & ZIMMERMAN, A. (1992). Protein phosphatases modulate the apparent agonist affinity of the light-regulated ion channel in retinal rods. Neuron 9, 739-748.
20. GORDON, S., DOWNING-PARK, J., TAM, B. & ZIMMERMAN, A. (1995a). Diacylglycerol analogs inhibit the rod cGMP-gated channel by a phosphorylation-independent mechanism. Biophys. J. 69, 409-417.
21. GORDON, S., DOWNING-PARK, J. & ZIMMERMAN, A. (1995b). Modulation of the cGMP-gated ion channel in frog rods by calmodulin and an endogenous inhibitory factor. J. Physiol. 486, 533-546.
22. GORDON, S., OAKLEY, J., VARNUM, M. & ZAGOTTA, W. (1996). Altered ligand specificity by protonation in the ligand binding domain of cyclic nucleotide-gated channels. Biochemistry 35, 3994-4001.
23. GORDON, S. & ZAGOTTA, W. (1995a). A histidine residue associated with the gate of the cyclic nucleotide-activated channels in rod photoreceptors. Neuron 14, 177-183.
24. GORDON, S. & ZAGOTTA, W. (1995b). Localization of regions affecting an allosteric transition in cyclic nucleotide-activated channels. Neuron 14, 857-864.
25. 2+ in cyclic nucleotide-gated channels. Proc. Natl. Acad. Sci. USA 92, 10222-10226.
26. GOULDING, E., TIBBS, G. & SIEGELBAUM, S. (1994). Molecular mechanism of cyclic nucleotide-gated channel activation. Nature (London) 372, 369-374.
27. HAMMES, G.G. & WU, C.-W. (1971). Regulation of enzyme activity. Science 172, 1205-1211.
28. HAYNES, L. & YAU, K.-W. (1985). Cyclic GMP-sensitive conductance in outer segment membrane of catfish cones. Nature (London) 317, 61-64.
29. HEYDUK, E., HEYDUK, T. & LEE, J. (1992). Intersubunit communications in E. coli cyclic AMP receptor protein: studies of the ligand binding domain. Biochemistry 31, 3682-3688.
30. HSU, Y.-T. & MOLDAY, R. S. (1993). Modulation of the cGMP-gated channel of rod photoreceptor cells by calmodulin. Nature (London) 361, 76-79.
31. ILDEFONSE, M. & BENNETT, N. (1991). Single-channel study of the cGMP-dependent conductance of retinal rods from incorporation of native vesicles into planar lipid bilayers. J. Mem. Biol. 123, 133-147.
32. JACKSON, M. (1993). The energetics of activation of membrane receptors. In Thermodynamics of Membrane Receptors and Channels (ed. M. Jackson), pp. 227-248. Boca Raton, FL: CRC Press.
33. KARLIN, A. (1967). On the application of 'a plausible model' of allosteric proteins to the receptor for acetylcholine. J. Theor. Biol. 16, 306-320.
34. KARPEN, J. & BROWN, R. (1996). Covalent activation of retinal rod cGMP-gated channels reveals a functional heterogeneity in the ligand binding sites. J. Gen. Physiol. 107, 169-181.
35. KARPEN, J. W., BROWN, R. L., STRYER, L. & BAYLOR, D. A. (1993). Interactions between divalent cations and the gating machinery of cyclic GMP-activated channels in salamander retinal rods. J. Gen. Physiol. 101, 1-25.
36. KÖRSCHEN, H., ILLING, M., SEIFERT, R., SESTI, F., WILLIAMS, A., GOTZES, S., COLVILLE, C., MÜLLER, F., DOSÉ, A., GODDE, M., MOLDAY, L., KAUPP, U. B. & MOLDAY, R. (1995). A 240 kDa protein represents the complete β subunit of the cyclic nucleotide-gated channel from rod photoreceptor. Neuron 15, 627-636.
37. KOSHLAND, D. E., NEMETHY, G. & FILMER, D. (1966). Comparison of experimental binding data and theoretical models in proteins containing subunits. Biochemistry 5, 365-385.
38. KRAMER, R. & TIBBS, G. (1996). Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action. J. Neurosci. 16, 1285-1293.
39. KUMAR, V. D. & WEBER, I. T. (1992). Molecular model of the cyclic GMP-binding domain of the cyclic GMP-gated ion channel. Biochemistry 31, 4643-4649.
40. LEFF, P. (1995). The two-state model of receptor activation. Trends Pharmacol. Sci. 16, 89-97.
41. LIMAN, E. R. & BUCK, L. B. (1994). A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron 13, 611-621.
42. LIU, M., CHEN, T.-Y., AHAMED, B., LI, J. & YAU, K.-W. (1994). Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel. Science 266, 1348-1354.
43. MATTHEWS, G. & WATANABE, S.-I. (1988). Activation of single channels from toad retinal rod inner segments by cyclic GMP: concentration dependence. J. Physiol. 403, 389-405.
44. MOLDAY, R. S. (1996). Calmodulin regulation of cyclic-nucleotide-gated channels. Curr. Opin. Neurobiol. 6, 445-452.
45. MONOD, J., WYMAN, J. & CHANGEUX, J.-P. (1965). On the nature of allosteric transitions: a plausible model. J. Mol. Biol. 12, 88-118.
46. PICONES , A. & KORENBROT, J. (1995). Spontaneous, ligand-independent activity of the cGMP-gated ion channels in cone photoreceptors of fish. J. Physiol. 585, 699-714.
47. Ross, E. M. (1996). Pharmacodynamics : Mechanism of drug action and relationship between drug concentration and effect. In Goodman & Gilman's The Pharmacological Basis of Therapeutics (ed. J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Ruddon and A. G. Gilman), pp. 20-42. McGraw-Hill.
48. SANFILIPPO, C. & MENINI, A. (1993). Cytosolic acidification enhances the activation by cAMP of the channel in retinal rod outer segments. Biophys. J. 64, A17.
49. SCHOLÜBBERS, H.-G., KNIPPENBERG, P. V., BARANIAK, J., STEC, W., MORR, M. & JASTORFF, B. (1984). Investigations on stimulation of lac transcription in vivo in Escherichia coli by cAMP analogues. Eur. J. Biochem. 138, 101-109.
50. SCOTT, S.-P., HARRISON, R., WEBER, I. & TANAKA, J. (1996). Predicted ligand interactions for 3′,5′-cyclic nucleotide gated channel binding sites: comparison of retina and olfactory binding site models. Protein Eng. 9, 333-344.
51. SERRE, V., ILDEFONSE, M. & BENNETT, N. (1995). Effects of cysteine modification on the activity of the cGMP-gated channel from retinal rods. J. Mem. Biol. 146, 145-162.
52. A receptors. Trends Pharmacol. Sci. 16, 162-168.
53. STEPHENSON, R. P. (1956). A modification of receptor theory. Br. J. Pharmacol. 11, 379-393.
54. TAYLOR, W. R. & BAYLOR, D. A. (1995). Conductance and kinetics of single cGMP-activated channels in salamander rod outer segments. J. Physiol. 483, 567-582.
55. TIBBS, G., GOULDING, E., LEYPOLD, B., LIU, D. & SIEGELBAUM, S. (1996). Spontaneous opening of cyclic nucleotide-gated channels supports an allosteric model of activation. Biophys. J. 70, A137.
56. VARNUM, M., BLACK, K. & ZAGOTTA, W. (1995). Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels. Neuron 15, 619-625.
57. VARNUM, M. D. & ZAGOTTA, W. N. (1996). Subunit interactions in the activation of cyclic nucleotide-gated ion channels. Biophys. J. 70, 2667-2679.
58. WEBER, I. T. & STEITZ, T. A. (1987). Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 Å resolution. J. Mol. Biol. 198, 311-326.
59. WYMAN, J. & GILL, S. J. (1990). Binding and Linkage. Mill Valley, CA: University Science Books.
60. ZAGOTTA, W. N. & SIEGELBAUM, S. A. (1996). Structure and function of cyclic nucleotide-gated chanels. Annu. Rev. Neurosci. 19, 235-263.
61. ZHANG, Y., CHEN, J. & AUERBACH, A. (1995). Activation of recombinant mouse acetylcholine receptors by acetylcholine, carbamylcholine and tetramethylammonium. J. Physiol. 486, 189-206.
62. ZIMMERMAN, A. L. & BAYLOR, D. A. (1986). Cyclic GMP-sensitive conductance of retinal rods consists of aqueous pores. Nature (London) 321, 70-72.