Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase

Cell

Volumn 108, Issue 2, 2002, Pages 207-220

  Stegmeier, Frank ^a   Visintin, Rosella ^a   Amon, Angelika ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; PHOSPHATASE; POLO LIKE KINASE; PROTEIN; PROTEIN CDC14; PROTEIN CDC5; PROTEIN ESP1; PROTEIN INHIBITOR; PROTEIN SLK19; PROTEIN SPO12; SEPARASE; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; CYTOLOGY; MITOSIS; NONHUMAN; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; YEAST;

SACCHAROMYCETALES;

EID: 0037169353     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00618-9     Document Type: Article

References (45)

1. Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast
2. Men and Sin: What's the difference?
3. The polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae
4. Pds1p of budding yeast has dual roles: Inhibition of anaphase initiation and regulation of mitotic exit
5. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p
6. Flp1, a fission yeast orthologue of the S. cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilization at the end of mitosis
7. Heat-inducible degron: A method for constructing temperature-sensitive mutants
8. The spindle checkpoint: Two transitions, two pathways
9. Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints
10. Cdc14 activates Cdc15 to promote mitotic exit in budding yeast
11. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae
12. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14
13. Slk19p is necessary to prevent separation of sister chromatids in meiosis I
14. Recombination and chromosome segregation during the single division meiosis in SPO12-1 and SPO13-1 diploids
15. Order of function of the budding-yeast mitotic exit-network proteins Tem1, Cdc15, Mob1, Dbf2, and Cdc5
16. The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis
17. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
18. Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex
19. Timing is everything: Regulation of mitotic exit and cytokinesis by the Men and Sin
20. Requirement for ESP1 in the nuclear division of Saccharomyces cerevisiae
21. Regulation of the APC and the exit from mitosis
22. Splitting the chromosome: Cutting the ties that bind sister chromatids
23. SPO12 and SIT4 suppress mutations in DBF2, which encodes a cell cycle protein kinase that is periodically expressed
24. Correct spindle elongation at the metaphase/anaphase transition is an APC-dependent event in budding yeast
25. Centromeric regions control autonomous segregation tendencies in single-division meiosis of Saccharomyces cerevisiae
26. Isolation of a Cdc25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1
27. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
28. APCCdc20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5
29. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex
30. Orchestrating anaphase and mitotic exit: Separase cleavage and localization of Slk19
31. Destruction of the CDC28/CLB kinase is not required for metaphase/anaphase transition in yeast
32. The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression
33. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage
34. The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition
35. Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression
36. Characterization of the Net1 cell cycle-dependent regulator of the Cdc14 phosphatase from budding yeast
37. Chromosome cohesion and segregation in mitosis and meiosis
38. Sister chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
39. Regulation of the mitotic exit protein kinases Cdc15 and Dbf2
40. The phosphatase Cdc14 triggers mitotic exit by reversal of CDK-dependent phosphorylation
41. Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus
42. Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeast
43. Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisiae
44. Whose end is destruction: Cell division and the anaphase-promoting complex
45. Slk19p is a centromere protein that functions to stabilize mitotic spindles