A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis

Molecular Biology of the Cell

Volumn 8, Issue 10, 1997, Pages 1877-1887

  Hwang, Lena H ^b   Murray, Andrew W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; GENE PRODUCT;

ARTICLE; CELL CYCLE; GENE MUTATION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; SCREENING; YEAST;

EID: 0030826689     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.8.10.1877     Document Type: Article

References (48)

1. 1 cyclins in the next cycle. Cell 77, 1037-1050.
2. 1 cyclins. Cell 74, 993-1007.
3. Araki, H., Awane, K., Ogawa, N., and Oshima, Y. (1992). The CDC26 gene of Saccharomyces cerevisiae is required for cell growth only at high temperature. Mol. Gen. Genet. 231, 329-331.
4. Bachmair, A., Finley, D., and Varshavsky, A. (1986). In vivo half-life of a protein is a function of its amino-terminal residue. Science 234, 179-185.
5. 2+-binding proteins. Proc. Natl. Acad. Sci. USA 83, 5512-5516.
6. Bradford, M. (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
7. Byers, B. (1981). Multiple roles of the spindle pole bodies in the life cycle of Saccharomyces cerevisiae. Mol. Genet. Yeast 16, 119-133.
8. Byers, B., and Goetsch, L. (1974). Duplication of spindle plaques and integration of the yeast cell cycle. Cold Spring Harbor Symp. Quant. Biol. 38, 123-131.
9. Ciechanover, A. (1994). The ubiquitin-proteasome proteolytic pathway. Cell 79, 13-21.
10. Company, N., Arenas, J., and Abelson, J. (1991). Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes. Nature 349, 487-493.
11. Dawson, I.A., Roth, S., and Artavanis-Tsakonas, S. (1995). The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J. Cell Biol. 129, 725-737.
12. Funabiki, H., Yamano, H., Kumada, K., Nagao, K., Hunt, T., and Yangida, M. (1996). Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature 381, 438-441.
13. 2/metaphase. Nature 366, 358-362.
14. Glotzer, M., Murray, A.W., and Kirschner, M.W. (1991). Cyclin is degraded by the ubiquitin pathway. Nature 349, 132-138.
15. Hardwick, K., and Murray, A.W. (1995). Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 131, 709-720.
16. Hardwick, K.G., Weiss, E., Luca, F.C., Winey, M., and Murray, A.W. (1996). Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science 273, 953-956.
17. Harlow, E., and Lane, D. (1988). Antibodies. A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
18. Hartwell, L.H., Culotti, J., and Reid, B. (1970). Generic control of cell division in yeast, I. Detection of mutants. Proc. Natl. Acad. Sci. USA 66, 352-359.
19. Hartwell, L.H., and Smith, D. (1985). Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics 110, 381-395.
20. Hershko, A., Ganoth, D., Pehrson, J., Palazzo, R.E., and Cohen, L.H. (1991). Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts. J. Biol. Chem. 266, 16376-16379.
21. Holloway, S.L., Glotzer, M., King, R.W., and Murray, A.W. (1993). Anaphase is initiated by proteolysis rather than by the inactivation of MPF. Cell 73, 1393-1402.
22. Hoyt, M.A., Trotis, L., and Roberts, B.T. (1991). S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66, 507-517.
23. Irniger, S., Piatti, S., Michaelis, C., and Nasmyth, K. (1995). Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 77, 1037-1050.
24. Johnson, E.S., Bartel, B., Seufert, W., and Varshavsky, A. (1992). Ubiquitin as a degradation signal. EMBO J. 11, 497-505.
25. King, R.W., Peters, J.M., Tugendreich, S., Rolfe, M., Hieter, P., and Kirschner, M.W. (1995). A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81, 279-288.
26. Lamb, J.R., Michaud, W.A., Sikorski, R.S., and Hieter, P.A. (1994). Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis. EMBO J. 13, 4321-4328.
27. Lee, N.H., et al. (1995). Comparative expressed sequence tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment. Proc. Natl. Acad. Sci. USA 92, 8303-8307.
28. Li, R., and Murray, A.W. (1991). Feedback control of mitosis in budding yeast. Cell 66, 519-531.
29. Maniatis, T., Fritsch, E.F., and Sambrook, J. (1982). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
30. Meluh, P.B., and Rose, M.D. (1990). KAR3, a kinesin-related gene required for yeast nuclear fusion. Cell 60, 1029-1041.
31. Morgan, D.O. (1995). Principles of CDK regulation. Nature 374, 131-134.
32. Murray, A.W., and Kirschner, M.W. (1989). Dominoes and clocks: the union of two views of cell cycle regulation. Science 246, 614-621.
33. Murray, A.W., Solomon, M.J., and Kirschner, M.W. (1989). The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature 339, 280-286.
34. Nurse, P. (1990). Universal control mechanism regulating cell cycle timing of M-phase. Nature 344, 503-508.
35. Palmer, R.E., Koval, M., and Koshland, D. (1989). The dynamics of chromosome movement in the budding yeast Saccharomyces cerevisiae. J. Cell Biol. 109, 3355-3366.
36. Sethi, N., Monteagudo, M.C., Koshland, D., Hogan, E., and Burke, D.J. (1991). The CDC20 gene product of Saccharomyces cerevisiae, a β-transducin homolog, is required for a subset of microtubule-dependent cellular processes. Mol. Cell. Biol. 11, 5592-5602.
37. Sherman, F., Fink, G., and Lawrence, C. (1974). Methods in Yeast Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
38. Sigrist, S., Jacobs, H., Stratmann, R., and C. Lehner (1995). Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B, and B3. EMBO J. 14, 4827-4838.
39. Sikorski, R.S., and Hieter, P. (1989). A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.
40. Smith, D.B., and Johnson, K.S. (1988). Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67, 31-40.
41. Sudakin, V., Ganoth, D., Dahan, A., Heller, H., Hershko, J., Luca, F.C., Ruderman, J.V., and Hershko, A. (1995). The cyclosome, a large complex containing cyclin-selective ubiquitination ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185-198.
42. Surana, U., Amon, A., Dowzer, C., McGrew, J., Byers, B., and Nasmyth, K. (1993). Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO J. 12, 1969-1978.
43. Wan, J., Xu, H., and Grunstein, M. (1992). CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle. J. Biol. Chem. 267, 11274-11280.
44. Weinert, T.A. (1992). Dual cell cycle checkpoints sensitive to chromosome replication and DNA damage in the budding yeast Saccharomyces cerevisiae. Radiat. Res. 132, 141-143.
45. Xiao, Z., McGrew, J.T., Schroeder, A.J., and Fitzgerald-Hayes, M. (1993). CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae. Mol. Cell. Biol. 13, 4691-4702.
46. Yamamoto, Y.A., Guacci, V., and Koshland, D. (1996). Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s). J. Cell Biol. 133, 99-110.
47. Zachariae, W., and Nasmyth, K. (1996). TPR proteins required for anaphase progression mediate ubiquitination of mitotic B type cyclins in yeast. Mol. Biol. Cell 7, 791-801.
48. Zachariae, W., Shin, T.H., Galova, M., Obermaier, B., and Nasmyth, K. (1996). Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science 274, 1201-1204.