Dietary flavonoids as potential neuroprotectants

Biological Chemistry

Volumn 383, Issue 3-4, 2002, Pages 503-519

  Youdim, Kuresh A ^a   Spencer, Jeremy P E ^a   Schroeter, Hagen ^a   Rice Evans, Catherine ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Brain; Flavonoids; Neuroprotection; Oxidative stress

Indexed keywords

ANTHOCYANIN; BAICALEIN; CROCIN; CURCUMIN; EPICATECHIN; FLAVANONE DERIVATIVE; FLAVONE DERIVATIVE; FLAVONOID; FLAVONOL DERIVATIVE; GARLIC EXTRACT; GINKGO BILOBA EXTRACT; GINSENG EXTRACT; NEUROPROTECTIVE AGENT; ORENGEDOKU TO; PARA COUMARIC ACID; PLANT EXTRACT; SHOSAIKOTO GO KEISHIKASHAKUYAKUTO; TOKISHAKUYAKU SAN;

AGING; ANIMAL CELL; ANTIOXIDANT ACTIVITY; BEVERAGE; CELL DEATH; CELL INTERACTION; CELL PROTECTION; CHRONIC DISEASE; COGNITION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG MECHANISM; DRUG STRUCTURE; FRUIT; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEARNING; MEMORY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; TASK PERFORMANCE; VEGETABLE;

AGING; ANIMALS; DIET; FLAVONOIDS; HUMANS; NEUROPROTECTIVE AGENTS;

ALLIUM SATIVUM; ANIMALIA; GINKGO BILOBA; PANAX GINSENG;

EID: 0036244730     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.052     Document Type: Review

References (211)

1. Distribution of morphine-6-glucuronide and morphine across the blood-brain-barrier in awake, freely moving rats investigated by in vivo microdialysis sampling
2. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation
3. Reduction in free radical-induced strand breaks and base damage through fast chemical repair by flavonoids
4. Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers
5. The ginkgo biloba extract (Egb 761) protects hippocampal neurons against cell death induced by beta-amyloid
6. The Gingko biloba extract (Egb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: Involvement of its flavonoids constituents and protein kinase C
7. Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons
8. Alzheimer's disease and oxidative stress: Implications for novel therapeutic approaches
9. Effect of Panax ginseng and diazepam on brain 5-hydroxytryptamine and its modification by diclofenac in rat
10. Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function
11. Effects of aging on cerebellar noradrenergic function and motor learning: Nutritional interventions
12. Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats
13. Interaction of flavonoids with ascorbate and determination of their univalent reduction potentials: A pulse radiolysis study
14. The effect of the phenolic antioxidant ferulic acid on the oxidation of low density lipoprotein depends on the pro-oxidant used
15. Absorption and DNA protective effects of flavonoid glycosides from an onion meal
16. Polyphenols, chemistry, dietary sources, metabolism and nutritional significance
17. Structural dependence of flavonoid interactions with copper ions: Implications for their antioxidant properties
18. Influence of ginseng saponin on the circadian rhythm of brain monoamine neurotransmitters
19. +-ATPase activity
20. Is memory impairment greater than cognitive impairment in moderate chronic alcoholics?
21. Antioxidant potential of intermediates in phenyl propanoid metabolism in higher plants
22. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin
23. An experimental study on the anti-senility effects of shou xing bu zhi Chung Hsi i Chieh Ho Tsa Chih
24. [Effects of ginseng root saponins on central transmitters and plasma corticosterone in warm-stress rats] Chung-Kuo Yao Li Hsueh Pao
25. [Learning by mice of Y-maze using drinking reinforcement and aversive ol-factory stimulus (beneficial effect of ginsenosides)]
26. 14C] deoxyglucose autoradiography
27. Oxidative stress and Alzheimer disease
28. [Ginkgo biloba extract (EGb 761). State of knowledge in the dawn of the year 2000]
29. Antioxidant strategies for neurodegenerative diseases
30. Effects of Lu-Duo-Wei capsules on superoxide dismutase activity and contents of malondialdehyde and lipofuscin in the brain of the housefly
31. Signal transduction by the JNK Group of MAP kinases
32. Intellectual and memory impairment in moderate and heavy drinkers
33. A receptor complex
34. Dietary antioxidants and Parkinson disease - The Rotterdam study
35. Protective and rescuing abilities of IGF-1 and some putative free-radical scavengers against beta-amyloid-induced toxicity in neurons
36. Antimutagenic effects of flavionoids, chalcons and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f] quinone (iQ) and other heterocyclic amine mutagens from cooked food
37. Studies on attenuation of post-ischemic brain injury by kampo medicines-inhibitory effects of free radical production
38. Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics
39. Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression
40. Increased survival in brain metastatic patients treated with stereotactic radiotherapy, omega three fatty acids and bioflavonoids
41. The effects of shosaiko-to-go-keishi-ka-shakuyaku-to (TJ-960) on ischemia-induced changes of brain acetylcholine and monoamine levels in gerbils
42. Acute and chronic effects of ginseng total saponin and amphetamine on fixed-interval performance in rats
43. Reactive oxygen species and the central nervous system
44. Free radical scavenging action of baicalein
45. Identification of the major antioxidative metabolites in biological fluids of the rat with ingested (+)-catechin and (-)-epicatechin
46. Advances in flavonoid research since 1992
47. Effects of chronic kombucha ingestion on open-field behaviors, longevity, appetitive behaviors, and organs in c57-bl/6 mice: A pilot study
48. Behavioral and ultrastructural changes in by chronic neuroinflammation in young rats
49. Therapy of cerebral ischemia
50. Diet and Parkinson's disease II: A possible role for the past intake of specific nutrients
51. Dietary antioxidant flavonoids and the risk of coronary heart disease: The Zutphen Elderly Study
52. The effects of black tea and other beverages on aspects of cognition and psychomotor performance
53. Increased choline acetyltransferase activity by Chinese herbal medicine Sho-saiko-to-go-keishi-ka-shakuyaku-to in aged rat brain
54. Free radicals, lipid peroxidation, SOD activity, neurotransmitters and choline acetyltransferase activity in the aged rat brain
55. Antioxidant effects of polyphenols in chocolate on low density lipoprotein both in vitro and in vivo
56. Intake of flavonols and flavanones and the risk of coronary heart disease in male smokers
57. The green tea extract epigallocatechin gallate is able to reduce neutrophil transmigration through monolayers of endothelial cells
58. Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury
59. Protective effect of green tea extract on ischemia/reperfusion-induced brain injury in Mongolian gerbils
60. Age-related increase in nitric oxide synthase activity in senescence accelerated mouse brain and the effect of long-term administration of superoxide radical scavenger
61. The suppression of age-related accumulation of lipid peroxides in rat brain by administration of Rooibos tea (Aspalathus linearis)
62. Oral administration of (-)catechin protects against ischemia-reperfusion-induced neuronal death in the gerbil
63. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms
64. Effects of single and repeated administrations of Toki-shakuyaku-san on the concentrations of brain neurotransmitters in mice
65. Age-related changes in the nigrostriatum: A behavioral and biochemical analysis
66. Psycomotor performance in the senescent rodent: Reduction of deficits via striatal dopamine receptor up-regulation
67. Selective cross activation /inhibition of second messenger systems and the reduction of age-related deficits in the muscarinic control of dopamine release from perfused rat striata
68. Oxidant injury in PC12 cells - A possible model of calcium deregulation in aging. I. Selectivity of protection against oxidative stress
69. Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioural deficits
70. Reversals of age-related declines in neuronal signal transduction, cognitive and motor behavioral deficits with diets supplemented with blueberry, spinach or strawberry dietary supplementation
71. + evoked striatal dopamine release
72. Monoamine metabolites, iron induced seizures, and the anticonvulsant effect of tannins
73. Chronic administration of Oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the Mongolian gerbil
74. + adenosine triphosphatase activity
75. Influence of retinol deficiency and curcumin/turmeric feeding on tissue microsomal membrane lipid peroxidation and fatty acids in rats
76. Inhibition of peroxynitrite-mediated oxidation of dopamine by flavonoids and phenolic antioxidants and their structural relationships
77. Antioxidant and antitumor promoting activities of the methanol extract of heat-processed ginseng
78. A review of nutrients and botanicals in the integrative management of cognitive dysfunction
79. Herbal medicine and the study of aging in senescence-accelerated mice (SAMP1TA/Ngs)
80. Antioxidant properties of a North American ginseng extract
81. Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway
82. Effect of plasma metabolites of (+)-catechin on monocyte adhesion to human aortic endothelial cells
83. The efficacy of an antioxidant cocktail on lipid peroxide level and superoxide dismutase activity in the aged rat brain and DNA damage in iron-induced epileptogenic foci
84. Different changes in concentrations of monoamines and their metabolites and amino acids in various brain regions by the herbal medicine/Toki-Shakuyaku-San between female and male senescence-accelerated mice (SAMP8)
85. Protective effect of oren-gedoku-to against induction of neuronal death by transient cerebral ischemia in the C57BL/6 mouse
86. Signal transduction events elicited by natural products, Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis
87. Glucuronidation of drugs: A re-evaluation of the pharmacological significance of the conjugates and modulating factors
88. Epicatechin and catechin are O-methylated and glucuronidated in the small intestine
89. Absorption and metabolism of resveratrol in the small intestine. Implications for resveratrol in vivo
90. Effect of 'β CATECHIN' on the life span of senescence accelerated mice (SAM-P8 strain)
91. Protective effects of the flavonoid mixture, sylimarin, on fetal rat brain and liver
92. Efficacy and safety of a Ginkgo biloba extract
93. Anti-oxidants and cognitive function: A review of clinical and epidemiologic studies
94. Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils
95. The effects of wine and tobacco consumption on cognitive performance in the elderly: A longitudinal study of relative risk
96. Brain mitochondria catalyse the oxidation of 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxylic acid (DHBT-1) to intermediates that irreversibly inhibit complex I and the pathogenesis of Parkinson's disease
97. The antioxidative property of green tea against iron-induced oxidative stress in rat brain
98. (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor κB
99. Theaflavin-3,3′-digallate from black tea blocks the nitric oxide synthase by down-regulating the activation of NF-κB in macrophages
100. 3-induced epilepsy
101. Effects of Guilingji on brain monoamines and their metabolites in mice
102. Actions of Ginkgo biloba related to potential utility for the treatment of conditions involving cerebral hypoxia
103. Ameliorative effects of tea catechins on active oxygen-related nerve cell injuries
104. The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
105. The importance of the inflammatory mechanisms in Alzheimer's disease
106. Neuroactive flavonoids: New ligands for the benzodiazepine receptor
107. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease and cancer
108. JNK and p38 stress kinases - Degenerative effectors of signal transduction-cascades in the nervous system
109. Identification of quercetin-3-O-β-glucorinoide as an antioxidative metabolite in rat plasma after oral administration of quercetin
110. Flavonoid-metal interactions in biological systems
111. Catechin metabolism: Glutathione conjugate formation catalyzed by tyrosinase, peroxidase and cytochrome P450
112. Caffeic acid, chlorogenic acid, and dihydrocaffeic acid metabolism: Glutathione conjugate formation
113. Prolongation of life span and improved learning in the senescence accelerated mouse produced by aged garlic extract
114. Allixin, a phytoalexin produced by garlic, and its analogues as novel exogenous substances with neurotrophic activity
115. Anti-ageing effect of aged garlic extract in the inbred brain atrophy mouse model
116. Flavonoid derivatives as adenosine receptor antagonists: A comparison of the hypothetical receptor binding site based on a comparative field analysis model
117. Ameliorative effects of chronic treatment using DX-9386, a traditional Chinese prescription, on learning performance and lipid peroxide content in senescence accelerated mouse
118. Beneficial effects of DX-9386, a traditional Chinese prescription, on memory disorder produced by lesioning the amygdala in mice
119. Effects of DX-9386, a traditional Chinese preparation, on passive and active avoidance performances in mice
120. Beneficial effects of S-113m, a novel herbal prescription, on learning impairment model in mice
121. An herbal prescription, S-113m, consisting of biota, ginseng and schizandra, improves learning performance in senescence accelerated mouse
122. Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse
123. Ameliorative effect of S-allylcysteine, a major thioallyl constituent in aged garlic extract, on learning deficits in senescence-accelerated mice
124. The efficacy of Ginkgo biloba on cognitive function in Alzheimer's disease
125. Identification of (-)-epicatechin metabolites and their metabolic fate in the rat
126. Wine consumption and dementia in the elderly: A prospective community study in the Bordeaux area
127. Analgesic activity of morphine-6-glucuronide
128. Flavonoids and the central nervous system: From forgotten factors to potent anxiolytic compounds
129. Rapid screening method for relative antioxidant activities of flavonoids and phenolics
130. Inhibition of peroxynitrite-mediated tyrosine nitration by catechin polyphenols
131. Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: Nitration or electron donation?
132. In vivo regulation of cerebral monoamine oxidase activity in senescent controls and chronically stressed mice by long-term treatment with Ginkgo biloba extract (EGb 761)
133. Determination of naringenin and its glucuronide conjugate in rat plasma and brain tissue by high-performance liquid chromatography
134. Effects of standardized ginseng extract on learning, memory and physical capabilities
135. Age-related differences in memory and in the memory effects of nootropic drugs
136. Modulation of the effects on learning and memory of nootropic drugs and central stimulants when applied together
137. Behavioral effects of stem-leaves extract from panax ginseng C.A. Meyer
138. Memory effects of standardized extracts of Panax ginseng (G115), Ginkgo biloba (GK 501) and their combination Gincosan (PHL-00701)
139. Induction of cyclooxygenase-2 in the rat brain after a mild episode of focal ischemia without tissue inflammation or neural cell damage
140. Alcohol, free radicals and antioxidants
141. Unique organoprotective properties of a novel IH636 grape seed proanthocyanidin extract on cadmium chloride-induced nephrotoxicity, dimethylnitrosamin (DMN)-induced splenotoxicity and MOCAP-induced neurotoxicity in mice
142. Novel biomarkers of the metabolism of caffeic acid derivatives in vivo
143. Structure-antioxidant activity relationship of flavonoids and phenolic acids
144. Bioavailability of flavonoids and potential bioactive forms in vivo
145. Melanogenesis-targeted antimelanoma pro-drug development: Effect of side-chain variations on the cytotoxicity of tyrosinase-gnerated ortho-quinones in a model screening system
146. Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors
147. Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants
148. The mechanism of alteration of monoamine metabolism in brain regions in marble burying behavior-isolated housing mice and effect of oren-gedoku-to on this alteration
149. Complement C1q is dramatically up-regulated in brain microglia in response to transient global cerebral ischemia
150. Different tissue distribution, elimination and kinetics of thyroxine and its conformational analog, the synthetic flavonoid Emd 49209 in the rat
151. Synthetic flavonoids cross the placenta in the rat and are found in the fetal brain
152. Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein
153. Flavonoids protect neurones from oxidised low-density lipoprotein-induced apoptosis involving JNK, c-jun and capase-3
154. Flavonoid B-ring chemistry and antioxidant activity: Fast reaction kinetics
155. Inbred SAM-P/10 as a mouse model of spontaneous, inherited brain atrophy
156. Localization of atrophy-prone areas in the aging mouse brain: Comparison between the brain atrophy model SAM-P/10 and the normal control SAM-R/1
157. Intestinal absorption of luteolin and luteolin-7-O-β-glucoside in rats and humans
158. Metabolic fate of luteolin and its functional activity at focal site
159. Protective effect of catechin against beta-amyloid toxicity in hippocampal neurons and PC12 cells
160. Psychomotor and spatial memory performance in aging male Fischer 344 rats
161. The effects of aging and oxidative stress on psychomotor and cognitive behavior
162. Influence of the antioxidant quercetin in vivo on the level of nitric oxide determined by electron paramagnetic resonance in rat brain during global ischemia and reperfusion
163. In vitro scavenging activity of some flavonoids and melanin against superoxide
164. The neuroprotective properties of the Ginkgo biloba leaf: A review of the possible relationship to platelet-activating factor (PAF)
165. Hoelen (Poria cocos Wolf) and ginseng (Panax ginseng C. A. Meyer), the ingredients of a Chinese prescription DX-9386, individually promote hippocampal long-term potentiation in vivo
166. A double-masked study of the effect of ginseng on cognitive functions
167. The small intestine can both absorb and glucuronidate luminal flavonoids
168. Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide induced cell death in neurons and fibroblasts
169. The role of β-glucuronidase in drug disposition and drug targeting in humans
170. Inflammatory mediators of cerebral endothelium: A role in ischemic brain inflammation
171. Transcription factor nuclear factor-kappa B is activated in neurons after focal cerebral ischemia
172. Amelioratory effect of dietary ingestion with red bell pepper on learning impairment in senescence-accelerated mice (SAMP8)
173. 3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue
174. Regulation of gene expression by herbal medicines - A new paradigm of gene therapy for multifocal abnormalities of genes
175. Crocin (crocetin di-gentiobiose ester) prevents the inhibitory effect of ethanol on long-term potentiation in the dentate gyrus in vivo
176. Grape polyphenols protect neurodegenerative changes induced by chronic ethanol administration
177. Effects of Kampo medicine, Toki-shakuyaku-san (Tang-Kuei-Shao-Yao-San), on choline acetyltransferase activity and norepinephrine contents in brain regions, and mitogenic activity of splenic lymphocytes in ovariectomized mice
178. Antioxidant activity of flavonoids, efficiency of singlet oxygen quenching
179. Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors
180. Determination of unbound hesperetin in rat blood and brain by microdialysis coupled to microbore liquid chromatography
181. Human UDP-glucuronosyltransferases: Metabolism, expression and disease
182. Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats
183. The efficacy of ginseng. A systematic review of randomised clinical trials
184. Structure-activity relationships of quercetin in antagonizing hydrogen peroxide-induced calcium dysregulation in PC12 cells
185. Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia
186. Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells
187. The cognitive, subjective, and physical effects of a Ginkgo biloba/panax ginseng combination in healthy volunteers with neurasthenic complaints
188. The effect of an extract of Ginkgo biloba, Egb 761, on cognitive behavior and longevity in the rat
189. Herbal remedies in psychiatric practice
190. Protective effect of Oren-gedoku-to (Huang-Lian-Jie-Du-Tang) against impairment of learning and memory induced by transient cerebral ischemia in mice
191. Prevention and repair of cerebral ischemia-reperfusion injury by Chinese herbal medicine, shengmai san, in rats
192. Spontaneous spongy degeneration of the brain stem in SAM-P/8 mice, a newly developed memory-deficient strain
193. Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin
194. Cacao liquor polyphenols reduce oxidative stress without maintaining α-tocopherol levels in rats fed a vitamin E-deficient diet
195. The Ginkgo biloba extract Egb 761 reduces the PC12 neuronal cells from β-amyloid-induced cell death by inhibiting the formation of β-amyloid-derived diffusible neurotoxic ligands
196. Improvement of learning ability in nmice and rats with the root extract of Ding Lang (Policias fruticosum L.)
197. Stimulation of sexual performance in male rats with the root extract of Ding Lang (Policias fruticosum L.)
198. The effect of Ding lang and (-)-deprenyl on the survival rate of male rats
199. Short-term dietary supplementation of blueberry polyphenolics: Beneficial effects on aging brain performance and peripheral tissue function
200. Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults
201. Apoptosis in the nervous system
202. 2+ influx in rat pancreatic acinar cells
203. Recent progress in the pharmacology of learning and memory in China Yao Hsueh Hsueh Pao
204. Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats Chung-Kuo Yao Li Hsueh Pao
205. Improving effects of DX-9386, a traditional Chinese medicinal prescription, on thymectomy-induced impairment of learning behaviors in mice
206. Effects of DX-9386, a traditional Chinese medicinal prescription, on long-term potentiation in the dentate gyrus in rats
207. Functional relationship between age-related immunodeficiency and learning deterioration
208. Oxidative stress and genetics in the pathogenesis of Parkinson's disease
209. Ginseng improves strategic learning by normal and brain-damaged rats