Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex

Journal of Medicinal Chemistry

Volumn 42, Issue 21, 1999, Pages 4343-4350

  Dekermendjian, Kim ^a   Kahnberg, Pia ^b   Witt, Michael Robin ^a   Sterner, Olov ^b   Nielsen, Mogens ^a   Liljefors, Tommy ^c  

^a Sct Hans Hospital   (Denmark)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE RECEPTOR; FLAVANOID; FLAVONE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; BRAIN; FLAVONOIDS; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, GABA-A; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032725338     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991010h     Document Type: Article

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