메뉴 건너뛰기




Volumn 5, Issue 3, 1998, Pages 235-243

Neuroactive flavonoids: New ligands for the Benzodiazepine receptors

Author keywords

Anxiolysis; Benzodiazepine receptors; Flavonoids; Partial agonist

Indexed keywords


EID: 0000073604     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0944-7113(98)80034-2     Document Type: Review
Times cited : (83)

References (63)
  • 6
    • 0029884812 scopus 로고    scopus 로고
    • Benzodiazepines on trial: A research strategy for their rehabilitation
    • Costa, E. and Guidotti, A.: Benzodiazepines on trial: a research strategy for their rehabilitation. TIPS. 17: 192-200, 1996.
    • (1996) TIPS , vol.17 , pp. 192-200
    • Costa, E.1    Guidotti, A.2
  • 7
    • 0025975894 scopus 로고
    • Synthesis and protein-tyrosine kinase inhibitory activities of flavonoids analogues
    • Cushman, M., Nagarathnam, D., Burg, D. L., Gearhlen, R. L.: Synthesis and protein-tyrosine kinase inhibitory activities of flavonoids analogues. J. Med Chem. 34: 798-806, 1991.
    • (1991) J. Med Chem. , vol.34 , pp. 798-806
    • Cushman, M.1    Nagarathnam, D.2    Burg, D.L.3    Gearhlen, R.L.4
  • 8
    • 0005194595 scopus 로고
    • Protein kinase C inhibition by flavonoids. Kinetic mechanisms and structure-activity relationships
    • Ferriola, P. C., Coy, V., Middleton, E.: Protein kinase C inhibition by flavonoids. Kinetic mechanisms and structure-activity relationships. Biochem. Pharmacol. 38: 245-254, 1989.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 245-254
    • Ferriola, P.C.1    Coy, V.2    Middleton, E.3
  • 9
    • 0028117787 scopus 로고
    • Flavonoids from Leptospermum scoparium with affinity to the benzodiazepine receptor characterized by structure activity relationships and in vivo studies of a plant extract
    • Haberlein, H., Tschiersch, K. P., Schafer, H. L.: Flavonoids from Leptospermum scoparium with affinity to the benzodiazepine receptor characterized by structure activity relationships and in vivo studies of a plant extract. Pharmazie 49: 912-921, 1994.
    • (1994) Pharmazie , vol.49 , pp. 912-921
    • Haberlein, H.1    Tschiersch, K.P.2    Schafer, H.L.3
  • 10
    • 0001377523 scopus 로고
    • Recent advances in the molecular pharmacology of benzodiazepine receptors and the structure - Activity relationships of their agonists and antagonists
    • Haefely, W., Kybura, E., Gerecke, M. and Möhler, H.: Recent advances in the molecular pharmacology of benzodiazepine receptors and the structure - activity relationships of their agonists and antagonists. Adv. Drug Res., 14: 165-322, 1985.
    • (1985) Adv. Drug Res. , vol.14 , pp. 165-322
    • Haefely, W.1    Kybura, E.2    Gerecke, M.3    Möhler, H.4
  • 11
    • 0025043989 scopus 로고
    • Novel anxiolytics that act as partial agonists at benzodiazepine receptors
    • Haefely, W. E., Martin, J. R., Schoch, P.: Novel anxiolytics that act as partial agonists at benzodiazepine receptors. TIPS 11: 452-456, 1990.
    • (1990) TIPS , vol.11 , pp. 452-456
    • Haefely, W.E.1    Martin, J.R.2    Schoch, P.3
  • 12
    • 0023856237 scopus 로고
    • 16-6028, a benzodiazepine receptor partial agonist, does not exhibit anticonvulsant tolerance in mice
    • Haig, J. R., Feely, M. R.: 16-6028, a benzodiazepine receptor partial agonist, does not exhibit anticonvulsant tolerance in mice. Eur. J. Pharmacol. 147: 282-285, 1988.
    • (1988) Eur. J. Pharmacol. , vol.147 , pp. 282-285
    • Haig, J.R.1    Feely, M.R.2
  • 13
    • 0003355452 scopus 로고
    • The flavonoids
    • Chapman and Hall, London
    • Harborne, J.B. (ed.): The flavonoids, Advances in research since 1986. Chapman and Hall, London, 1994.
    • (1994) Advances in Research since , vol.1986
    • Harborne, J.B.1
  • 14
    • 0025922247 scopus 로고
    • A modulation of memory: The role of endogenous benzodiazepines
    • A modulation of memory: the role of endogenous benzodiazepines. TIPS 12: 260-265, 1991.
    • (1991) TIPS , vol.12 , pp. 260-265
    • Izquierdo, I.1    Medina, J.H.2
  • 15
    • 0025079655 scopus 로고
    • Benzodiazepine receptor ligand influences on acquisition: Suggestion of an endogenous modulatory mechanism mediated by benzodiazepine receptors
    • Izquierdo, I., Pereira, M. E., Medina, J. H.: Benzodiazepine receptor ligand influences on acquisition: suggestion of an endogenous modulatory mechanism mediated by benzodiazepine receptors. Behav. Neural Biol. 54: 27-41, 1990.
    • (1990) Behav. Neural Biol. , vol.54 , pp. 27-41
    • Izquierdo, I.1    Pereira, M.E.2    Medina, J.H.3
  • 16
    • 0030051539 scopus 로고    scopus 로고
    • Interactions of flavonoids and other phytochemicals with adenosine receptors
    • Ji, X., Melman, N., Jacobson, K. A.: Interactions of flavonoids and other phytochemicals with adenosine receptors. J. Med Chem. 39: 781-788, 1996.
    • (1996) J. Med Chem. , vol.39 , pp. 781-788
    • Ji, X.1    Melman, N.2    Jacobson, K.A.3
  • 17
  • 18
    • 0026465456 scopus 로고
    • In vitro inhibition of adenosine deaminase by flavonoids and related compounds
    • Koch, H. P., Jager, W., Groh, U., Plank, G.: In vitro inhibition of adenosine deaminase by flavonoids and related compounds. Meth. Fin. Exp. Clin. Pharmacol. 14: 413-417, 1992.
    • (1992) Meth. Fin. Exp. Clin. Pharmacol. , vol.14 , pp. 413-417
    • Koch, H.P.1    Jager, W.2    Groh, U.3    Plank, G.4
  • 19
    • 0021895059 scopus 로고
    • The amnesic action of benzodiazepines in man
    • Lister, R.: The amnesic action of benzodiazepines in man. Neurosci. Biobehav. Rev. 9: 87-93, 1985.
    • (1985) Neurosci. Biobehav. Rev. , vol.9 , pp. 87-93
    • Lister, R.1
  • 21
    • 0021049851 scopus 로고
    • Isolation and identification of "diazepam-like" compounds from bovine urine
    • Luk, K. C., Stern, L., Weigele, M., O'Brien, R. A., Spirst, N.: Isolation and identification of "diazepam-like" compounds from bovine urine. J. Nat. Prod. 46: 852-861, 1983.
    • (1983) J. Nat. Prod. , vol.46 , pp. 852-861
    • Luk, K.C.1    Stern, L.2    Weigele, M.3    O'Brien, R.A.4    Spirst, N.5
  • 22
    • 0028792457 scopus 로고
    • 6,3′-dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties
    • Marder, M., Viola, H., Wasowski, C., Wolfman, C. Waterman, P., Medina, J. H., Paladini, A. C.: 6,3′-dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties. Bioorg. Med. Chem. Lett. 5: 2717-2720, 1995.
    • (1995) Bioorg. Med. Chem. Lett. , vol.5 , pp. 2717-2720
    • Marder, M.1    Viola, H.2    Wasowski, C.3    Wolfman, C.4    Waterman, P.5    Medina, J.H.6    Paladini, A.C.7
  • 23
    • 0004396593 scopus 로고    scopus 로고
    • 6 Bromoflavone, a high affinity ligand for the benzodiazepine receptors is a member of a family of active flavonoids. Biochem
    • Marder, M., Vidla, H., Wasowski, C., Wolfman, C., Waterman, P., Cassels, B. K., Medina, J. H., Paladini, A. C.: 6 Bromoflavone, a high affinity ligand for the benzodiazepine receptors is a member of a family of active flavonoids. Biochem. Biopbys. Res. Comm. 223: 384-389, 1996a.
    • (1996) Biopbys. Res. Comm. , vol.223 , pp. 384-389
    • Marder, M.1    Vidla, H.2    Wasowski, C.3    Wolfman, C.4    Waterman, P.5    Cassels, B.K.6    Medina, J.H.7    Paladini, A.C.8
  • 24
    • 0000593328 scopus 로고    scopus 로고
    • Cirsiliol and caffeic acid ethyl ester isolated from Salvia guaranitica, are competitive ligands for the central benzodiazepine receptors
    • Marder, M., Viola, H., Wasowski, C., Wolfman, C., Waterman, P. G., Medina, J. H., Paladini, A. C.: Cirsiliol and caffeic acid ethyl ester isolated from Salvia guaranitica, are competitive ligands for the central benzodiazepine receptors. Phytomedicine 3: 29-31, 1996b.
    • (1996) Phytomedicine , vol.3 , pp. 29-31
    • Marder, M.1    Viola, H.2    Wasowski, C.3    Wolfman, C.4    Waterman, P.G.5    Medina, J.H.6    Paladini, A.C.7
  • 26
    • 0029670123 scopus 로고    scopus 로고
    • A receptors subtypes really occur in the brain?
    • A receptors subtypes really occur in the brain? TINS 19: 139-143, 1996.
    • (1996) TINS , vol.19 , pp. 139-143
    • McKernan, R.M.1    Whiting, P.J.2
  • 28
    • 0025136261 scopus 로고
    • Chrysin (5,7 di-OH flavone) a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties
    • Medina, J. H., Paladini A. C., Wolfman, C. Levi, M., Calvo, D., Diaz, L. Peña, C.: Chrysin (5,7 di-OH flavone) a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem. Pharmacol. 40: 2227-2232, 1990.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 2227-2232
    • Medina, J.H.1    Paladini, A.C.2    Wolfman, C.3    Levi, M.4    Calvo, D.5    Diaz, L.6    Peña, C.7
  • 29
    • 0024839984 scopus 로고
    • Benzodiazepine-like molecules as well as other ligands for the brain benzodiazepine receptor are relatively common constituents of plants
    • Medina, J. H., Peña, C., Levi M., Wolfman, C., Paladini A. C.: Benzodiazepine-like molecules as well as other ligands for the brain benzodiazepine receptor are relatively common constituents of plants. Biochem. Biophys. Res. Comm. 265: 547-55, 1989.
    • (1989) Biochem. Biophys. Res. Comm. , vol.265 , pp. 547-555
    • Medina, J.H.1    Peña, C.2    Levi, M.3    Wolfman, C.4    Paladini, A.C.5
  • 30
    • 84892138934 scopus 로고
    • The impact of plant flavonoids on mammalian biology: Implications for immunity, inflammation and cancer
    • Harbone J. B. (ed.) Chapman and Hall, London
    • Middleton E., Kandaswami C.: The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer, Pages 619-645, in Harbone J. B. (ed.) The Flavonoids, Chapman and Hall, London, 1994.
    • (1994) The Flavonoids , pp. 619-645
    • Middleton, E.1    Kandaswami, C.2
  • 31
    • 0027237649 scopus 로고
    • Commonly occurring plant flavonoids have estrogenic activity
    • Miksicek, R. J.: Commonly occurring plant flavonoids have estrogenic activity. Mol. Pharmacol. 44: 37-43, 1993.
    • (1993) Mol. Pharmacol. , vol.44 , pp. 37-43
    • Miksicek, R.J.1
  • 33
    • 0017661950 scopus 로고
    • Benzodiazepine receptors: Demonstration in the central nervous system
    • Mohler, N., Okada, T.: Benzodiazepine receptors: demonstration in the central nervous system. Science 198: 849-851, 1977.
    • (1977) Science , vol.198 , pp. 849-851
    • Mohler, N.1    Okada, T.2
  • 34
    • 0025059553 scopus 로고
    • Physical dependence induced in DBA/2j mice by benzodiazepine receptor full agonists, but not by partial agonist Ro 16-6028
    • Moreau, J. L., Jenck, F., Pieri, L., Schoch, P., Martin, J. R., Haefely, W. E.: Physical dependence induced in DBA/2j mice by benzodiazepine receptor full agonists, but not by partial agonist Ro 16-6028. Eur. J. Pharmacol. 190: 269-273, 1990.
    • (1990) Eur. J. Pharmacol. , vol.190 , pp. 269-273
    • Moreau, J.L.1    Jenck, F.2    Pieri, L.3    Schoch, P.4    Martin, J.R.5    Haefely, W.E.6
  • 35
    • 0025171542 scopus 로고
    • Studies with alpidem in normal volunteers and anxious patients
    • Morton, S., Lader, M.: Studies with alpidem in normal volunteers and anxious patients. Pharmacopsychiatry 23: 120-123, 1990.
    • (1990) Pharmacopsychiatry , vol.23 , pp. 120-123
    • Morton, S.1    Lader, M.2
  • 37
    • 0023732498 scopus 로고
    • High affinity of naturally-occurring biflavonoid, amentoflavone, to brain benzodiazepine receptors in vitro
    • Nielsen, M., Frokjaer, S., Braestrup, C.: High affinity of naturally-occurring biflavonoid, amentoflavone, to brain benzodiazepine receptors in vitro. Biochem. Pharmacol. 37: 3285-3287, 1988.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 3285-3287
    • Nielsen, M.1    Frokjaer, S.2    Braestrup, C.3
  • 38
    • 0029983706 scopus 로고    scopus 로고
    • Pharmacologically active components of a peruvian medicinal plant, Huanarpo (Jatropha cilliata, M. Arg.)
    • Japan
    • Okuyama, E., Okamoto, Y., Yamazaki, M., Satake, M.: Pharmacologically active components of a peruvian medicinal plant, Huanarpo (Jatropha cilliata, M. Arg.) Chem. Pharm. Bull. (Japan). 44: 333-336, 1996.
    • (1996) Chem. Pharm. Bull. , vol.44 , pp. 333-336
    • Okuyama, E.1    Okamoto, Y.2    Yamazaki, M.3    Satake, M.4
  • 39
    • 3342886937 scopus 로고
    • Benzodiazepine/GABA receptors and chloride channels
    • Alan R. Liss, New York
    • Olsen, R. W., Venter, J. C.: Benzodiazepine/GABA receptors and chloride channels. Structural and Functional Properties. Alan R. Liss, New York, 1986.
    • (1986) Structural and Functional Properties
    • Olsen, R.W.1    Venter, J.C.2
  • 41
    • 0027179013 scopus 로고
    • Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence
    • Perrault, G., Morel, E., Sanger, D. J., Zivkovic, B.: Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence. Neuropharmacol. 32: 855-863, 1993.
    • (1993) Neuropharmacol. , vol.32 , pp. 855-863
    • Perrault, G.1    Morel, E.2    Sanger, D.J.3    Zivkovic, B.4
  • 43
    • 0025991547 scopus 로고
    • Effect of two flavonoid compounds on the central nervous system. Analgesic activity
    • Picq, M., Cheav, S. V., Prigent, A. F.: Effect of two flavonoid compounds on the central nervous system. Analgesic activity. Life Sci. 49: 1979-1988, 1991.
    • (1991) Life Sci. , vol.49 , pp. 1979-1988
    • Picq, M.1    Cheav, S.V.2    Prigent, A.F.3
  • 44
    • 0018378474 scopus 로고
    • Flavonoids are selective cyclic GMP phosphodiesterase inhibitors
    • Ruckstuhl, L., Beretz, A., Anton, R., Laudry, Y.: Flavonoids are selective cyclic GMP phosphodiesterase inhibitors. Biochem. Pharmacol. 28: 535-538, 1979.
    • (1979) Biochem. Pharmacol. , vol.28 , pp. 535-538
    • Ruckstuhl, L.1    Beretz, A.2    Anton, R.3    Laudry, Y.4
  • 45
    • 0031415450 scopus 로고    scopus 로고
    • Anxiolytic natural and synthetic flavonoid ligands of the central benzodiazepine receptor have no effect on memory task in rats
    • Salgueiro, J. B., Ardenghi, P., Dias, M., Ferreira, M. B. C., Izquierdo, I., Medina, J. H.: Anxiolytic natural and synthetic flavonoid ligands of the central benzodiazepine receptor have no effect on memory task in rats. Pharmacol. Biochem. Behav., 58: 887-891, 1997.
    • (1997) Pharmacol. Biochem. Behav. , vol.58 , pp. 887-891
    • Salgueiro, J.B.1    Ardenghi, P.2    Dias, M.3    Ferreira, M.B.C.4    Izquierdo, I.5    Medina, J.H.6
  • 46
    • 0027865331 scopus 로고
    • Aspects of benzodiazepine receptor structure and function with relevance to drug tolerance and dependence
    • Schoch, P., Moreau, J. L., Martin, J. R., Haefely, W. E.: Aspects of benzodiazepine receptor structure and function with relevance to drug tolerance and dependence. Biochem. Soc. Symp. 59: 121-134, 1992.
    • (1992) Biochem. Soc. Symp. , vol.59 , pp. 121-134
    • Schoch, P.1    Moreau, J.L.2    Martin, J.R.3    Haefely, W.E.4
  • 48
    • 0011358876 scopus 로고
    • Molecular heterogeneity of benzodiazepine receptors
    • Siegharth, W., Karobath, M.: Molecular heterogeneity of benzodiazepine receptors. Nature 285: 826-828, 1980.
    • (1980) Nature , vol.285 , pp. 826-828
    • Siegharth, W.1    Karobath, M.2
  • 49
    • 0030693304 scopus 로고    scopus 로고
    • A receptors
    • A receptors. TIPS: 18: 425-429, 1997.
    • (1997) TIPS , vol.18 , pp. 425-429
    • Sigel, E.1    Buhr, A.2
  • 50
    • 0017614063 scopus 로고
    • Benzodiazepine receptors in rat brain
    • Squires, R. F., Braestrup, C.: Benzodiazepine receptors in rat brain. Nature 266: 732-734, 1977.
    • (1977) Nature , vol.266 , pp. 732-734
    • Squires, R.F.1    Braestrup, C.2
  • 51
    • 0017869434 scopus 로고
    • The benzodiazepine story
    • Sternbach, L. H.: The benzodiazepine story. Prog. Drug Res. 22: 229-266, 1978.
    • (1978) Prog. Drug Res. , vol.22 , pp. 229-266
    • Sternbach, L.H.1
  • 52
    • 0002605219 scopus 로고
    • Harborne J. B., Mabry T. J. and Mabry M. (eds.) Chapman and Hall, London
    • Swain, T.: pages 1096-1129, in Harborne J. B., Mabry T. J. and Mabry M. (eds.) The Flavonoids, Chapman and Hall, London, 1975.
    • (1975) The Flavonoids , pp. 1096-1129
    • Swain, T.1
  • 53
    • 0021944233 scopus 로고
    • Some evidence for amnesic-like effects of benzodiazepines in animals
    • Thiebot, M. H.: Some evidence for amnesic-like effects of benzodiazepines in animals. Neurosci. Biobehav. Ref. 9: 95-100, 1985.
    • (1985) Neurosci. Biobehav. Ref. , vol.9 , pp. 95-100
    • Thiebot, M.H.1
  • 54
    • 0021704521 scopus 로고
    • Kinetics differences between type I and type II benzodiazepine receptors. mol
    • Trifiletti, R. R., Lo, M. M. S., Snyder, S. H.: Kinetics differences between type I and type II benzodiazepine receptors. mol. Pharmacol. 26: 228-234, 1984.
    • (1984) Pharmacol. , vol.26 , pp. 228-234
    • Trifiletti, R.R.1    Lo, M.M.S.2    Snyder, S.H.3
  • 55
    • 0031552094 scopus 로고    scopus 로고
    • 6-bromo-3′-nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites
    • Viola, H., Marder, M., Wolfman, C., Wasowski, C., Medina, J. H., Paladini, A. C.: 6-bromo-3′-nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites. Bioorg. Med. Chem. Lett. 7: 373-378, 1997a.
    • (1997) Bioorg. Med. Chem. Lett. , vol.7 , pp. 373-378
    • Viola, H.1    Marder, M.2    Wolfman, C.3    Wasowski, C.4    Medina, J.H.5    Paladini, A.C.6
  • 56
    • 0029054098 scopus 로고
    • Apigenin, a component of Matricaria recutita flowers is a central benzodiazepine receptors-ligand with anxiolytic effects
    • Viola, H., Wasowski, C., Levi, N., Wolfman, C., Silveira, R., Dajas, F., Medina, J. H., Paladini, A. C.: Apigenin, a component of Matricaria recutita flowers is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med. 61: 213-216, 1995.
    • (1995) Planta Med. , vol.61 , pp. 213-216
    • Viola, H.1    Wasowski, C.2    Levi, N.3    Wolfman, C.4    Silveira, R.5    Dajas, F.6    Medina, J.H.7    Paladini, A.C.8
  • 57
    • 0001995567 scopus 로고    scopus 로고
    • Sedative and hypnotic properties of Salvia guaranitica St. Hil. and of its active principle: Cirsiliol
    • Viola, H., Wasowski, C., Marder, M., Wolfman, C., Paladini, A. C., Medina, J. H.: Sedative and hypnotic properties of Salvia guaranitica St. Hil. and of its active principle: Cirsiliol. Phytomedicine 4: 45-50, 1997b.
    • (1997) Phytomedicine , vol.4 , pp. 45-50
    • Viola, H.1    Wasowski, C.2    Marder, M.3    Wolfman, C.4    Paladini, A.C.5    Medina, J.H.6
  • 58
    • 0028017688 scopus 로고
    • Isolation of pharmacologically active benzodiazepine receptor ligands from Tilia tomentosa (Tiliaceae)
    • Viola, H., Wolfman, C., Levi, M., Wasowski, C., Peña, C., Medina, J.H., Paladini, A.C.: Isolation of pharmacologically active benzodiazepine receptor ligands from Tilia tomentosa (Tiliaceae). J. Ethnopharmacol. 44: 47-53, 1994.
    • (1994) J. Ethnopharmacol. , vol.44 , pp. 47-53
    • Viola, H.1    Wolfman, C.2    Levi, M.3    Wasowski, C.4    Peña, C.5    Medina, J.H.6    Paladini, A.C.7
  • 59
    • 0025176844 scopus 로고
    • Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice
    • Wei, H., Tye, L., Bresnick, E., Birt, D. F.: Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res. 50: 499-502, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 499-502
    • Wei, H.1    Tye, L.2    Bresnick, E.3    Birt, D.F.4
  • 62
    • 0027976019 scopus 로고
    • Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea
    • Wolfman, C., Viola, H., Paladini, A. C., Dajas, F., Medina, J. H.: Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacol. Biochem. Behav. 47: 1-4, 1994.
    • (1994) Pharmacol. Biochem. Behav. , vol.47 , pp. 1-4
    • Wolfman, C.1    Viola, H.2    Paladini, A.C.3    Dajas, F.4    Medina, J.H.5
  • 63
    • 0026878098 scopus 로고
    • Benzodiazepines: Use, abuse and consequences
    • Woods, J. H., Katz, J. L., Winger, G.: Benzodiazepines: use, abuse and consequences. Pharmacol. Rev. 44: 151-347, 1992.
    • (1992) Pharmacol. Rev. , vol.44 , pp. 151-347
    • Woods, J.H.1    Katz, J.L.2    Winger, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.