Effects of single and repeated administrations of Toki-shakuyaku-san on the concentrations of brain neurotransmitters in mice

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 20, Issue 1, 1998, Pages 11-17

  Itoh, Tadanobu ^a   Murai, Shigeo ^a   Saito, Hiroko ^a   Masuda, Yoshikatsu ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Acetylcholine; Brain; Monamine related substances; Toki shakuyaku san

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 5 HYDROXYINDOLEACETIC ACID; ACETYLCHOLINE; BRAIN MONOAMINE; DOPAMINE; HOMOVANILLIC ACID; KAMPO; NORADRENALIN; PLANT EXTRACT; SEROTONIN; TOKISHAKUYAKU SAN;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG EFFECT; HERBAL MEDICINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NEUROTRANSMISSION; NONHUMAN; ORAL DRUG ADMINISTRATION; SEROTONINERGIC SYSTEM;

ACETYLCHOLINE; ANIMALS; BRAIN CHEMISTRY; DOPAMINE; DRUGS, CHINESE HERBAL; MALE; MICE; NEUROTRANSMITTER AGENTS; NOREPINEPHRINE; PLANTS, MEDICINAL;

EID: 0031978706     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.1998.20.1.485617     Document Type: Article

References (18)

1. Fukushima, M. Corpus luteum insufficiency syndrome: Endocrinological and clinical effects of treatment with Toki-shakuyaku-san olone. World Obstel Gynecol 1982 (3 Suppl.): 127-34.
2. Fukushima, M., Ota, H. Endocrinological effects of Shakuyakukanzo-to (TJ-68) and Toki-shakuyaku-san (TJ-23) in sulpiride-induced hyperprolactinaemic rats. In: Recent Advances in the Pharmacology of Kampo (Japanese Herbal) Medicines. Hosoya, E., Yamamura, Y. (Eds.). Excerpta Medica: Tokyo 1988, 155-62.
3. Koyama, T., Hagino, N., Cothron, A. W., Saito, M. Effect of combined treatment with Toki-shakuyaku-san and human menopausal gonadotropin on follicular maturation and ovulation in immature female rats. In: Recent Advances in the Pharmacology of Kampo (Japanese Herbal) Medicines. Hosoya, E., Yamamura, Y. (Eds.). Excerpta Medica: Tokyo 1988, 150-4.
4. Koyama, T., Ohara, M., Ichimura, M., Saito, M. Effect of Japanese Kampo medicine on hypothalamic-pituitary-ovarian function in women with ovarian insufficiency. Am J Chinese Med 1988, 16: 47-55.
5. Hagino, N., Koyama, T., Cothron, A. W. Neuroendocrine effects of Toki-shakuyaku-san(TJ-23) on ovulation. In: Human Reproduction: Current Status and Future Prospects. Izuka, R., Semm, K. (Eds.). Excepta Medica: Amsterdam 1988, 433-5.
6. Hagino, N. The role of maternal nicotine in the development of nicotine acetylcholine receptors and hypothalamic dopaminergic neurones in the fetal brain. In: Developmental Neuroscience: Physiological, Pharmacological and Clinical Aspects. Caciagli, F., Giacobini E., Paoletti, R. (Eds.). Elsevier Science Publishers, B.V. 1984, 127-30.
7. Koyama, T., Hagino, N. Effect of Toki-shakuyaku-san on the nicotine-acetylcholine receptors. JAMA 1988 (4 Suppl.): 22-3.
8. Hagino, N., Sakamoto, S., Torie, K. Effects of Toki-shakuyaku-san (TJ-23) on the brain acetylcholine nervous cells and its receptors in the senile rats. J Med Pharmaceut Soc WAKAN-YAKU 1990, 7: 340-1.
9. Nagatsuka, Y., Fujimoto, K., Ikeguchi, K., Yoshida, M. Chinese herbal medicine "Toki-Shakuyaku-San" increases choline acetyltransferase activity in the cortex senescent rat. Alzheimer's and Parkinson's Disease of the 2nd International Conference (Japan) 1989 (Suppl.): 123.
10. Hagine, N. Effects of Toki-shakuyaku-san on the central nervous system and usefulness as a therapeutic agent of dementia. J Med Pharmaceut Soc WAKAN-YAKU 1989, 6: 561.
11. Mizushima, N., Ikeshita, T. Effect of Toki-shakuyaku-san on the senile dementia. J Med Pharmaceut Soc WAKAN-YAKU 1989, 6: 456-7.
12. Fujiwara, M., Iwasaki, K., Ogata, T. Effect of TJ-23 on scopolamine-induced deficit of learning and memory in rats. Alzheimer's and Parkinson's Disease of the 2nd International Conference (Japan) 1989 (Suppl.): 124.
13. Potter, P.E., Meek, J.L., Neff, N.H. Acetylcholine and choline in neural tissue measured by HPLC with electrochemical detection, J Neurochem 1983, 41: 188-94.
14. Glowinski, J., Iversen, L.L. Regional studies of catecholamine in the rat. Brain J Neurochem 1966, 13: 655-69.
15. Murai, S., Saito, H., Masuda, Y., Itoh, T. Rapid determination of norepinephrine, dopamine, serotonin, their precursor amino acids, and related metabolises in discrete brain areas of mice within ten minutes by HPLC with electrochemical detection. J Neurochem 1988, 50: 473-9.
16. Murai, S., Miyale, H., Saito, H., Nagahama, H., Masuda, Y., Itoh, T. Simple determination of acetylcholine and choline within 4 min by HPLC-ECD and immobilized enzyme column in mice discrete brain areas. J Pharmacol Method 1989, 21: 255-62.
17. Hagino, N., Koyama, T. Stimulation of nicotine acetylcholine receptor synthesis in the brain by Toki-shakuyaku-san(TJ-23). In: Recent Advances in the Pharmacology of Kampo (Japanese Herbal) Medicines. Hosoya, E., Yamamura, Y. (Eds.). Excerpta Medica: Tokyo 1988, 144-9.
18. Koyama, T. Effect of Kampo medicine on the neurotransmitters. Kampo Shinryo 1992, 11: 1-3.