Different tissue distribution, elimination, and kinetics of thyroxine and its conformational analog, the synthetic flavonoid EMD 49209 in the rat

Endocrinology

Volumn 138, Issue 1, 1997, Pages 79-84

  Schroder Van Der Elst J P ^a   Van Der Heide, D ^a   Rokos, H ^b   Kohrle J ^c   Morreale De Escobar, G ^d  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b Firma Henning Berlin   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3',5' DIBROMO 4',6 DIHYDROXY 3 METHYLFLAVONE; 4',6 DIHYDROXY 3',5 DIIODO 3 METHYLFLAVONE; EMD 49209; FLAVONE DERIVATIVE; LIOTHYRONINE; THYROXINE; THYROXINE DEIODINASE; THYROXINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME SUBSTRATE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; THYROID DISEASE; THYROID HORMONE METABOLISM; TRADITIONAL MEDICINE;

EID: 2042442587     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.1.4848     Document Type: Article

References (28)

1. Köhrle J, Auf'mkolk M, Spanka M, Irmscher K, Cody V, Hesch RD 1988 Iodothyronine deiodinase is inhibited by plant flavonoids. In: Cody V, Middleton E, Harborne JB, Beretz A (eds) Plant Flavonoids in Biology and Medicine. Liss, New York, pp 359-372
2. Köhrle J, Spanka M, Irmscher K, Hesch RD 1988 Flavonoid effects on transport, metabolism and action of thyroid hormones. In: Cody V, Middleton E, Harborne JB, Beretz A (eds) Plant Flavonoids in Biology and Medicine. Liss, New York, vol 11:323-340
3. Cody V 1989 Physical and conformational properties of flavonoids. In: Gaitan E (ed) Environmental Goitrogenesis. CRC Press, Boca Raton, pp 35-42
4. Cody V, Köhrle J, Hesch RD 1989 Structure-activity relationships of flavonoids as inhibitors of iodothyronine deiodinase. In: Gaitan E (ed) Environmental Goitrogenesis. CRC Press, Boca Raton, pp 57-69
5. Lindsay RH, Gaitan E, Cooksey RC 1989 Pharmacokinetics and intrathyroidal effects of flavonoids. In: Gaitan E (ed) Environmental Goitrogenesis. CRC Press, Boca Raton, pp 43-56
6. Gaitan E 1996 Editorial: flavonoids and the thyroid. Nutrition 12:127-129
7. Spanka M, Hesch RD, Irmscher K, Köhrle J 1990 5′-Deiodination in rat hepatocytes: effects of specific flavonoid inhibitors. Endocrinology 126: 1660-1667
8. Duan W, Richardson SJ, Köhrle J, Chang L, Southwell BR, Harms PJ, Brack CM, Pettersson TM, Schreiber G 1995 Binding of thyroxine to pig transthyretin, its cDNA structure, and other properties. Eur J Biochem 230:977-986
9. Auf'mkolk M, Köhrle J, Hesch RD, Cody V 1986 Inhibition of rat liver iodothyronine deiodinase. Interactions of aurones with the iodothyronine ligand binding site. J Biol Chem 261:11623-11630
10. Schröder-van der Elst JP, van der Heide D, Köhrle J 1991 In vivo effect of flavonoid EMD 21388 on thyroid hormone secretion and metabolism in rats. Am J Physiol 261:E227-E232
11. Pedraza PE, Escobar del Rey F, Morreale de Escobar G 1993 Effects of flavonoid EMD 21388 on thyroid hormone status of rat dams and their fetuses at term. J Endocrinol Invest 16(Suppl 2):12
12. Pedraza PE, Morreale de Escobar G 1994 Effects of flavonoid EMD 21388 on extrathyroidal thyroxine and 3,5,3′-triiodothyronine levels and 5′-iodothyronine deiodinase activities in rat dams and fetuses near term. J Endocrinol Invest 17(Suppl 1):19
13. 3 in the female rat. J Endocrinol Invest 17(Suppl 1):19
14. Ad Hoc Committee on Standards for Nutritional Studies 1977 Report of the American Institute of Nutrition. J Nutr 7:1340-1348
15. Van Doorn J, Van der Heide D, Roelfsema F 1983 Sources and quantity of 3,5,3′-triiodothyronine in several tissues of the rat. J Clin Invest 72:1176-1184
16. Schröder-van der Elst JP, van der Heide D 1990 Effects of 5,5′-diphenylhydantoin on thyroxine and 3,5,3′-triiodothyronine concentrations in several tissues of the rat. Endocrinology 126:826-831
17. Van Doorn J, Roelfsema F, Van der Heide D 1985 Concentrations of thyroxine and 3,5,3′-triiodothyronine at 34 different sites in euthyroid rats as determined by an isotopic equilibrium technique. Endocrinology 117:1201-1206
18. Caster WO, Poncelet J, Simon AB, Armstrong WD 1956 Tissue weights of the rat. Normal values determined by dissection and chemical methods. Proc Soc Exp Biol Med 91:122-126
19. 3 in the plasma of rats during the first 3 months of life. Acta Endocrinol (Copenh) 93:448-454
20. Mendel CM, Laughton CW, McMahon FA, Cavalieri RR 1991 Inability to detect an inhibitor of thyroxine-serum protein binding in sera from patients with non-thyroidal illness. Metabolism 40:491-502
21. 4 from transthyretin. Endocrinology 130:1525-1532
22. Griffiths LA 1982 Mammalian metabolism of flavonoids. In: Harborne J, Maybry TJ (eds) The Flavonoids: Advances in Research. Chapman and Hall, London, pp 681-692
23. Hackett AM 1986 The metabolism of flavonoid compounds in mammals. Cody V, Middleton Jr E, Harborne JB (eds) Plant Flavonoids in Biology and Medicine. Liss, New York, pp 177-193
24. Morreale de Escobar G, Calvo R, Escobar del Rey F, Obregon MJ 1994 Thyroid hormones in tissues from fetal and adult rats. Endocrinology 134:2410-2415
25. Lueprasitsakul W, Alex WS, Fang SL, Pino S, Irmscher K, Köhrle J, Braverman LE 1990 Flavonoid administration immediately displaces thyroxine from serum transthyretin, increases serum free thyroxine, and decreases serum TSH in the rat. Endocrinology 126:2890-2895
26. Köhrle J, Fang SL, Yang Y, Irmscher K, Hesch RD, Pino S, Alex S, Braverman LE 1989 Rapid effects of the flavonoid EMD 21388 on serum thyroid hormone binding and thyrotropin regulation in the rat. Endocrinology 125:532-537
27. Chanoine JP, Alex S, Fang SL, Stone S, Leonard JL, Köhrle J, Braverman LE 1992 Role of transthyretin in the transport of thyroxine from the blood to the choroid plexus, the cerebrospinal fluid and the brain. Endocrinology 130:933-938
28. Abend SL, Fang SL, Alex S, Braverman LE, Leonard JL 1991 Rapid alteration in circulating free thyroxine modulates pituitary type II 5′-deiodinase and basal thyrotropin secretion in the rat. J Clin Invest 88:898-903