Cisplatin-induced apoptosis of DRG neurons involves bax redistribution and cytochrome c release but not fas receptor signaling

Neurobiology of Disease

Volumn 9, Issue 2, 2002, Pages 220-233

  McDonald, Elizabeth S ^a   Windebank, Anthony J ^a  

^a MAYO CLINIC   (United States)

Author keywords

Chemotherapy; Inbred MRL LPR; Nerve growth factor; Neurotoxicity; Neurotrophins; NGF withdrawal

Indexed keywords

CELL DNA; CISPLATIN; CYTOCHROME C; FAS ANTIGEN; NERVE GROWTH FACTOR; NEUROTROPHIN; PROTEIN BAX;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DRUG MECHANISM; EMBRYO; ENZYME RELEASE; IN VITRO STUDY; IN VIVO STUDY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RAT; SPINAL GANGLION; STRESS;

EID: 0036199556     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2001.0468     Document Type: Article

References (65)

1. Apoptosis control by death and decoy receptors
2. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
3. Regulation of cell death protease caspase-9 by phosphorylation
4. Fas/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: Induction of caspase-dependent cell death and activation of NF-κB
5. IGF-1 promotes Schwann cell motility and survival via activation of Akt
6. Enhanced induction of bax gene expression in H460 and H1299 cells with the combined treatment of cisplatin and adenovirus mediated wt-p53 gene transfer
7. The lpr and gld genes in systemic autoimmunity: Life and death in the Fas lane
8. Bax, Bid and the permeabilization of the mitochondrial outer membrane in apoptosis
9. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
10. Apoptosis-inducing factor (AIF): A ubiquitous mitochondrial oxidoreductase involved in apoptosis
11. Signal transduction by the JNK group of MAP kinases
12. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
13. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
14. Comparison of apoptosis in wild-type and fas-resistant cells: Chemotherapy-induced apoptosis is not dependent on fas/fas ligand interactions
15. Bax-induced cytochrome c release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions
16. Fas/CD95/APO-1 can function as a death receptor for neuronal cells in vitro and in vivo and is upregulated following cerebral hypoxic-ischemic injury to the developing rat brain
17. L
18. Alterations in cell cycle regulation underlie cisplatin induced apoptosis of dorsal root ganglion neurons in vivo
19. Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells
20. The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells
21. Activation of the CD95 (APO-1/Fas) pathway in drug- and γ-irradiation-induced apoptosis of brain tumor cells
22. Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells
23. Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle
24. Ceramide initiates NFκB-mediated caspase activation in neuronal apoptosis
25. Regulated targeting of bax to mitochondria
26. Enforced dimerization of bax results in its translocation, mitochondrial dysfunction, and apoptosis
27. Progressive paresthesias after cessation of therapy with very high-dose cisplatin
28. L during apoptosis
29. Bax directly induces release of cytochrome c from isolated mitochondria
30. CDDP induces p53-dependent apoptosis in tongue cancer cells
31. Induction of NF-κB by the Akt/PKB kinase
32. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
33. Insulin-like growth factor-1 protects axotomized rat retinal ganglion cells from secondary death via PI3-K-dependent akt phosphorylation and inhibition of caspase-3 in vivo
34. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
35. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to fas ligand induction and cell death
36. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
37. CD95 ligand (Fas-L/Apo-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons
38. Fas receptor and neuronal death after spinal cord ischemia
39. Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons
40. Mechanisms of neurotoxic injury and cell death
41. Endogenous bax translocation in SH-SY5Y human neuroblastoma cells and cerebellar granule neurons undergoing apoptosis
42. Regulation of CD95 (Apo-1/Fas) ligand and receptor expression in squamous-cell carcinoma by interferon-γ and cisplatin
43. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53
44. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
45. Bax membrane insertion during fas (CD95)-induced apoptosis precedes cytochrome c release and is inhibited by Bcl-2
46. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
47. Conformation of the Bax C-terminus regulates subcellular location and cell death
48. Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of fas or FADD/MORT1 signaling: Implications for cancer therapy
49. Cisplatin-induced apoptotic cell death in mouse hybrid neurons is blocked by antioxidents through suppression of cisplatin-mediated accumulation of p53 but not fas/fas ligand
50. Phase I trial of Dolastatin-10 (NSC 376128) in patients with advanced solid tumors
51. BAX translocation is a critical event in neuronal apoptosis: Regulation by neuroprotectants, Bcl-2, and caspases
52. Inhibition of apoptotic signaling cascades causes loss of trophic factor dependence during neuronal maturation
53. Programmed cell death of embryonic motoneurons triggered through the fas death receptor
54. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
55. Fas (CD95/APO-1) plays a role in the pathophysiology of focal cerebral ishchemia
56. Bcl-2 prolongs cell survival after bax-induced release of cytochrome c
57. Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis
58. Role of hypoxia-induced bax translocation and cytochrome c release in reoxygenation injury
59. A structural view of mitochondria-mediated apoptosis
60. The Akt proto-oncogene links ras to pak and cell survival signals
61. Cisplatin neuropathy: Clinical, electrophysiologic, morphologic, and toxicologic studies
62. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
63. Specific inhibition of myelination by lead in vitro: Comparison with arsenic, thallium, and mercury
64. Movement of bax from the cytosol to mitochondria during apoptosis
65. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked