Steroid hormone receptors and dietary ligands: A selected review

Proceedings of the Nutrition Society

Volumn 61, Issue 1, 2002, Pages 105-122

  Jacobs, Miriam N ^a   Lewis, David F V ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Endocrine disruption; Human oestrogen receptors; Ligand receptor interaction; Steroid hormone receptors

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANTIOXIDANT; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450; ESTRADIOL; ESTROGEN RECEPTOR; ISOFLAVONE; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PESTICIDE; PHYTOESTROGEN; PLASTICIZER; POLYCHLORINATED BIPHENYL; PREGNANE X RECEPTOR; PREGNENOLONE; PROGESTERONE; STEROID RECEPTOR;

BRAIN FUNCTION; BREAST CANCER; CARCINOGENESIS; CONFERENCE PAPER; DIETARY INTAKE; ENZYME ACTIVITY; ESTROGEN BLOOD LEVEL; HORMONE METABOLISM; HORMONE RECEPTOR INTERACTION; HUMAN; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; NUTRIENT; OVARY CANCER; RECEPTOR BINDING; TRANSCRIPTION REGULATION; XENOBIOTIC METABOLISM;

BOS TAURUS;

EID: 0036176735     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1079/PNS2001140     Document Type: Conference Paper

References (162)

1. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse
2. Testicular cancer in nine northern European countries
3. Evolution, nutrition, intestinal microflora and prevention of cancer: A hypothesis
4. Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: An assessment of the biological and epidemiological evidence
5. Exposure to exogenous estrogens in food: Possible impact on human development and health
6. Hormone studies flawed, researcher warns
7. Synergistic activation of estrogen receptor with combinations of environmental chemicals
8. In vitro synergistic interaction of alligator and human estrogen receptors with combinations of environmental chemicals
9. Testing for endocrine disruption post EDSTAC: Extrapolation from low dose rodent effects to humans
10. Induction of hyperplasia and increased DNA content in the uterus of immature rats exposed to coumestrol
11. Decline in semen quality among fertile men in Paris during the past 20 years
12. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements
13. Differential response of estrogen receptor α and estrogen receptor β to partial estrogen agonists/antagonists
14. Peroxisome proliferator-activated receptor gamma (PPARγ) activation and its consequences in humans
15. Does estrogen receptor expression in normal breast tissue predict breast cancer risk?
16. Phyto-oestrogens: Where are we now?
17. Health effects of dioxins: People are animals and vice versa!
18. Orphan nuclear receptors - New ligands and new possibilities
19. SXR, a novel steroid and xenobiotic sensing nuclear receptor
20. A case of a laboratory animal feed with high estrogenic activity and its impact on in vivo responses to exogenously administered estrogens
21. Estrogens and related substances in plants
22. Effects of pesticides on the ratio of 16 alphahydroxyestrone/ 2hydroxyestrone: A biologic marker of breast cancer risk
23. Role of the estrogen receptor in the action of organochlorine pesticides on estrogen metabolism in human breast cancer cell lines
24. Aromatase and its inhibitors
25. Molecular basis of agonism and antagonism in the oestrogen receptor
26. Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor
27. Effects of environmental estrogens on tumor necrosis factor α-mediated apoptosis in MCF-7 cells
28. Physiological effects of phyto-oestrogens in relation to cancer and other human health risks
29. Phyto-oestrogens through the life cycle
30. How significant are environmental oestrogens to women?
31. Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR
32. Developmental effects of endocrine disrupting chemicals in wildlife and humans
33. Peroxisome proliferator-activated receptor α is an androgen responsive gene in human prostate and is highly expressed in prostatic adenocarcinoma
34. Endocrine disrupting contaminants and hormone dynamics: Lessons from wildlife
35. Pesticides and breast cancer: Fact or fad?
36. Medical hypothesis: Xenoestrogens as preventable causes of breast cancer
37. Medical hypothesis: Bifunctional genetic-hormonal pathways to breast cancer
38. Use of AhR knockout (AhR-/-) mice to investigate the role of the Ah receptor on the disposition of TCDD
39. The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue
40. Estrogenic induction of spermatogenesis in the hypogonadal mouse
41. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer
42. Androstane metabolites bind to and deactivate the nuclear receptor CAR-β
43. Polycystic ovary syndrome: Evidence for a primary disorder of ovarian steroidogenesis
44. Clinical significance of expression of estrogen receptor alpha and beta mRNA in ovarian cancers
45. A hypersensitive estrogen receptor alpha mutation in premalignant breast lesions
46. Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-tricloroethane with estrogen receptors α and β
47. Interactions of indolo [3-2-6] carbazoles and related polycyclic aroma hydrocarbons with specific binding sites for 2,3,7,8-tetrachlorodobenzo-p-dioxin in rat liver
48. Evidence for the increasing incidence of abnormalities of the human testis: A review
49. Endocrine screening methods workshop report: Detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms
50. Ecosystems and embryos - Is there a scientific basis for concern?
51. Estrogen receptor β - A new dimension in estrogen mechanism of action
52. The role of the ERβ in oestrogen mediated carcinogenesis
53. The aryl hydrocarbon receptor: A comparative perspective
54. The estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ER α transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens
55. Activation of the Ah receptor by tryptophan and tryptophan metabolites
56. A role for oestrogens in the male reproductive system
57. Genistein potentiates the radiation effect on prostrate carcinoma cells
58. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer nodule of the CYP2B gene
59. Exposure to bisphenol α advances puberty
60. Plasma organochlorine levels and the risk of breast cancer
61. Pesticide residues and breast cancer. The harvest of a silent spring
62. Investigation of polybrominated diphenyl ether in Scottish and European farmed atlantic salmon (Salmo salar), salmon aquaculture feed and fish oils
63. Investigation of selected PCBs and organochlorine pesticides in farmed atlantic salmon (Salmo salar), salmon aquaculture feed and fish oil components of the feed
64. Investigation of PCDDs, PCDFs and selected coplanar PCBs in Scottish farmed Atlantic salmon
65. A QSAR study of organochlorine and isoflavonoid compounds ligand binding affinity to the human oestrogen receptor α
66. Homology modelling of the human peroxisome proliferator activated receptorα (PPARα) ligand binding domain from the human PPARγ crystal structure
67. Combination effects of different ratios of PCB 153 and the phytoestrogen genistein upon DNA synthesis in an MCF-7 breast cancer cell line
68. Structural requirements and cell type specifity for ligand activation of peroxisome proliferator activated receptors
69. The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
70. Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist
71. Phylogenetic analyses reveal ancient duplication of estrogen receptor isoforms
72. Estrogen levels in childhood determined by ultrasensitive recombinant cell bioassay
73. Orphan nuclear receptors: Shifting endocrinology into reverse
74. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
75. Breast cancer and serum organochlorines: A prospective study among white, black and Asian women
76. Sexual precocity after immigration from developing countries to Belgium: Evidence of previous exposure to organochlorine pesticides
77. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
78. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β
79. Neonatal genistein chemoprevents mammary carcinogenesis
80. Expression of estrogen receptor (ER) ER-β in normal and malignant prostatic epithelial cells: Regulation by methylation and involvement of growth regulation
81. Expression of human estrogen receptor α and β, progesterone receptor and androgen receptor mRNA in normal and malignant ovarian epithelial cells
82. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
83. A QSAR study of some PCBs ligand-binding affinity to the cytosolic Ah receptor
84. Molecular modelling of the rat peroxisome proliferator-activated receptor α (rPPARα) by homology with the human retinoic acid X receptor α (hRARα) and investigation of peroxisome proliferator binding interactions: QSARs
85. Exposure of populations to dioxins and related compounds
86. Steroidogenic factor-1 (SF-1) is essential for endocrine development and function
87. Synergistic effect of environmental oestrogens: Report withdrawn
88. Gene imprinting in developmental toxicology: A possible interface between physiology and pathology
89. P450 enzymes of estrogen metabolism
90. Induction of drug metabolism by nuclear receptor CAR: Molecular mechanisms and implications for drug research
91. Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate pregnane X receptor-mediated transcription
92. In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors α and β
93. The CYP3A family
94. In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PBDEs and polybrominated bisphenol A compounds
95. Up-regulation of peroxisome proliferator-activated receptor α (PPARα) and PPARγ messenger ribonucleic acid expression in the liver in murine obesity: Troglitazone induces expression of PPARγ responsive adipose tissue-specific genes in the liver of obese diabetic mice
96. Relative potency of xenobiotic estrogens in an acute in vivo mammalian assay
97. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer
98. Inhibition of peroxisome proliferator signaling pathways by thyroid hormone recepter - Competitive binding to the response element
99. St. John's Wort induces hepatic drug metabolism through activation of the pregnane X receptor
100. ER beta: Identification and characterization of a novel human estrogen receptor
101. Terminal differentiation of human breast cancer through PPAR gamma
102. Exposure to diethylstilbestrol during a critical developmental period of the mouse reproductive tract leads to persistent induction of two estrogen regulated genes
103. Epidermal growth factor replaces estrogen in the stimulation of female genital tract growth and differentiation
104. Uterine adenocarcinoma in mice treated neonatally with genistein
105. Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex
106. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma
107. Survival of reproductive behaviours in estrogen receptor beta gene-deficient (βERKO) male and female mice
108. Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites
109. Steroid and related receptors
110. Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene
111. Mixtures of four organochlorines enhance human breast cancer cell proliferation
112. Identification of estrogen receptor beta (2), a functional variant of estrogen receptor beta expressed in normal rat tissues
113. Levels of PCDD/PCDFs, PCBs and OC pesticides in breast adipose tissue of women enrolled in a California breast cancer study
114. Activation of the Ah Receptor signal transduction pathway by bilrubin and biliverdin
115. Mechanistic aspects - The dioxin (aryl hydrocarbon) receptor
116. Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer
117. Potency of combined estrogenic pesticides
118. A preliminary study of the effect of estrogen dose on growth in Turner's syndrome
119. Effects of low doses of estradiol on 6-month growth rates and predicted height in patients with Turner syndrome
120. Peroxisome proliferator-activated receptor γ ligands inhibit estrogen biosynthesis in human breast tissue: Possible implications for breast cancer therapy
121. Xenoestrogens and breast cancer
122. Human exposure to endocrine-active chemicals: Hazard assessment problems
123. Environmental and dietary estrogens and human health: Is there a problem?
124. Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element
125. Do males rely on female hormones?
126. Hormones and testis development and the possible adverse effects of environmental chemicals
127. Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethyl-stilbestrol: A possible role for estrogens in Sertoli cell development
128. Are oestrogens involved in falling sperm counts and disorders of the reproductive tract?
129. Environmental estrogens induce transcriptionally active estrogen receptor dimers in yeast: Activity potentiated by the coactivator RIP 140
130. Differential effects of aroclors and DDT on growth factor gene expression and receptor tyrosine kinase activity in human breast epithelial cells
131. DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells
132. cDNA-cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor
133. Estrogen is more than just a sex hormone: Novel sites for estrogen action in the hippocampus and cerebral cortex
134. The role of local estrogen biosynthesis in males and females
135. Aryl hydrocarbon receptor-dependent induction of Cyplal by bilirubin in mouse hepatatoma hepa 1c1c7 cells
136. The E-SCREEN assay as a tool to identify estrogens: An update on estrogenic environmental pollutants
137. Hypothesis for mammary tumourigenesis in Sprague-Dawley rats exposed to certain triazine herbicides
138. Distribution of messenger RNA's encoding oestrogen receptor isoforms in female reproductive tissues
139. Pesticide exposure and decreased fertilisation rates in vitro
140. Essential fatty acids in early life: Structural and functional role
141. The estrogen receptor family
142. The human nuclear xenobiotic receptor PXR structural determinants of directed promiscuity
143. P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
144. Steroid hormone receptors and their regulation by phosphorylation
145. Cross species and interassay comparisons of phytoestrogen action
146. The PPARs: From orphan receptors to drug discovery
147. Minireview: Neuroprotective effects of oestrogen - New insights into mechanisms of action
148. Environmental organochlorine exposure and potential etiologic factor in breast cancer
149. Blood levels of organochlorine residues and risk of breast cancer
150. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
151. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors
152. Mechanism for the suppression of the mammalian stress response by genistein, an anticancer phytoestrogen from soy
153. Pristanic acid and phytanic acid: Naturally occurring ligands for the nuclear receptor peroxisome proliferator activated receptorα