The role of local estrogen biosynthesis in males and females

Trends in Endocrinology and Metabolism

Volumn 11, Issue 5, 2000, Pages 184-188

  Simpson, Evan ^a   Rubin, Gary ^a   Clyne, Colin ^a   Robertson, Kirsten ^a   O'Donnell, Liza ^a   Jones, Margaret ^a   Davis, Susan ^b  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b Jean Hailes Foundation for Women's Health   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; ESTROGEN;

ADIPOSE TISSUE; AGING; BONE; ENZYME RELEASE; ESTROGEN SYNTHESIS; FEMALE; HUMAN; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; OSTEOPOROSIS; PARACRINE SIGNALING; POSTMENOPAUSE; PRIORITY JOURNAL; REVIEW; SPERMATOGENESIS; TESTIS;

ADIPOSE TISSUE; ANIMALS; AROMATASE; ESTROGENS; FEMALE; HUMANS; MALE; PROTEIN PRECURSORS; SPERMATOGENESIS; TESTIS;

EID: 0033939017     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(00)00254-X     Document Type: Review

References (49)

1. Simpson E.R.et al. Aromatase expression in health and disease. Recent Prog. Horm. Res. 52:1997;185-213.
2. Bulun S.E., Simpson E.R. Competitive RT-PCR analysis indicates levels of aromatase cytochrome P450 transcripts in adipose tissue of buttocks, thighs, and abdomen of women increase with advancing age. J. Clin. Endocrinol. Metab. 78:1994;428-432.
3. Agarwal V.R.et al. Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients. J. Clin. Endocrinol. Metab. 81:1996;3843-3849.
4. Harada N.et al. Tissue-specific expression of the human aromatase cytochrome P450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis. Proc. Natl. Acad. Sci. U. S. A. 90:1993;11312-11316.
5. Zhou C.et al. Aromatase gene expression and its exon 1 usage in human breast tumorsDetection of aromatase messenger RNA by reverse transcription-polymerase chain reaction. J. Steroid Biochem. Mol. Biol. 59:1996;163-171.
6. Zhao Y.et al. Aromatase P450 gene expression in human adipose tissue. role of a Jak/STAT pathway in regulation of the adipose-specific promoter J. Biol. Chem. 270:1995;16449-16457.
7. Zhao Y.et al. Tumor necrosis factor-α stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter I. 4. Mol. Endocrinol. 10:1996;1350-1357.
8. 2via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase gene). Endocrinology. 137:1996;5739-5742.
9. Sasano H.et al. Aromatase in human bone tissue. J. Bone Miner. Res. 12:1997;1416-1423.
10. Shozu M., Simpson E.R. Aromatase expression of human osteoblast-like cells. Mol. Cell. Endocrinol. 139:1998;117-129.
11. Smith E.P.et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. New Engl. J. Med. 331:1994;1056-1061.
12. Carani C.et al. Aromatase deficiency in the male. effect of testosterone and estradiol treatment New Engl. J. Med. 337:1997;91-95.
13. Labrie F.et al. Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites. intracrinology J. Clin. Endocrinol. Metab. 82:1997;2403-2409.
14. Simpson E.R., Davis S.R. Why do the clinical sequelae of estrogen deficiency affect women more frequently than men? J. Clin. Endocrinol. Metab. 83:1998;2214.
15. Lubahn D.et al. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc. Natl. Acad. Sci. U. S. A. 90:1993;11162-11166.
16. Fisher C.R.et al. Characterization of mice deficient in aromatase (ArKO) due to targeted disruption of the cyp19 gene. Proc. Natl. Acad. Sci. U. S. A. 95:1998;6965-6970.
17. Robertson K.M.et al. Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene. Proc. Natl. Acad. Sci. U. S. A. 1999;7986-7991.
18. Bruch H.R.et al. Androstenedione metabolism in cultured human osteoblast-like cells. J. Clin. Endocrinol. Metab. 75:1992;101-105.
19. Bayard F.et al. Oestrogen biosynthesis, oestrogen metabolism and functional oestrogen receptors in bovine aortic endothelial cells. Ciba Found. Symp. 191:1995;122-132.
20. Sasano H.et al. Aromatase and sex steroid receptors in human vena cava. Endocr. J. 46:1999;233-242.
21. Naftolin F.et al. The formation of estrogens by central neuroendocrine tissues. Recent Prog. Horm. Res. 31:1975;295-319.
22. Siiteri P.K., MacDonald P.C. Role of extraglandular estrogen in human endocrinology. Greep R.O., Astwood E.B. Handbook of Physiology (Vol. 2). 1973;619-629 American Physiological Society.
23. Melton L.J. Epidemiology of spinal osteoporosis. Spine. 22:1997;2S-11S.
24. Huang Z.et al. Dual effects of weight and weight gain on breast cancer risk. J. Am. Med. Assoc. 278:1997;1407-1411.
25. Hemsell D.L.et al. Plasma precursors of estrogen. II. Correlation of the extent of conversion of plasma androstenedione to estrone with age. J. Clin. Endocrinol. Metab. 38:1974;476-479.
26. Tsai-Morris C.H.et al. Cellular localization of rat testicular aromatase activity during development. Endocrinology. 116:1985;38-46.
27. Nitta H.et al. Germ cells of the mouse testis express P450 aromatase. Endocrinology. 132:1993;1396-1401.
28. Morishima A.et al. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J. Clin. Endocrinol. Metab. 80:1995;3689-3698.
29. Oz O.K.et al. Bone has a sexually dimorphic response to aromatase deficiency. J. Bone Miner. Res. 15:2000;507-514.
30. Yaffe K.et al. Estrogen therapy in postmenopausal women. effects on cognitive function and dementia J. Am. Med. Assoc. 279:1998;688-695.
31. Labrie F.et al. DHEA and the intracine formation of androgens and estrogens in peripheral target tissues. its role during aging Steroids. 63:1998;322-328.
32. Labrie F.et al. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J. Clin. Endocrinol. Metab. 82:1997;2396-2402.
33. Sasano H.et al. Aromatase and 17β-hydroxysteroid dehydrogenase type 1 in human breast carcinoma. J. Clin. Endocrinol. Metab. 81:1996;4042-4046.
34. Corbould A.M.et al. Expression of types 1, 2 and 3 β-hydroxysteroid dehydrogenase in subcutaneous abdominal and intra-abdominal adipose tissue of women. J. Clin. Endocrinol. Metab. 83:1998;187-194.
35. Raisz L.G.et al. Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women. J. Clin. Endocrinol. Metab. 81:1995;37-43.
36. Davis S.R.et al. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas. 21:1995;227-236.
37. Spiegelman B.M. PPAR-gamma. adipogenic regulator and thiazolidinedione receptor Diabetes. 47:1998;507-514.
38. Hotamisligil G.S.et al. Adipose expression of tumor necrosis factor. direct role in obesity-linked insulin resistance Science. 259:1993;87-91.
39. Uysal K.T.et al. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature. 389:1997;610-614.
40. Rubin G.L.et al. Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue. possible implications for breast cancer therapy Cancer Res. 60:2000;1604-1608.
41. Bruning P.F.et al. Insulin resistance and breast-cancer risk. Int. J. Cancer. 52:1992;511-516.
42. Hess R.A.et al. A role for oestrogens in the male reproductive system. Nature. 390:1997;509-512.
43. Levallet J.et al. Expression and immunolocalization of functional cytochrome P450 aromatase in mature rat testicular cells. Biol. Reprod. 58:1998;919-926.
44. Van Pelt A.M.et al. Ontogeny of estrogen receptor-beta expression in rat testis. Endocrinology. 140:1999;478-483.
45. Saunders P.T.K.et al. Expression of oestrogen receptor beta (ERβ) occurs in multiple cell types, including some germ cells, in the rat testis. J. Endocrinol. 156:1998;R13-R17.
46. Collaborative re-analysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,441 women without breast cancer. Lancet. 350:1997;1047-1059.
47. Pasqualini J.R.et al. Concentrations of estrone, estradiol and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients. J. Clin. Endocrinol. Metab. 81:1996;1460-1464.
48. Service R.F. New role for estrogen in cancer? Science. 279:1998;1631-1633.
49. Harris R.E.et al. Nonsteroidal anti-inflammatory drugs and breast cancer. Epidemiology. 1:1996;203-205.