-
3
-
-
0033624575
-
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
-
(2000)
Nature
, vol.26
, pp. 76-79
-
-
Altshuler, D.1
Hirschhorn, J.N.2
Klannemark, M.3
Lindgren, C.M.4
Vohl, M.-C.5
Nemesh, J.6
Lane, C.R.7
Schaffner, S.F.8
Bolk, S.9
Brewer, C.10
Tuomi, T.11
Gaudet, D.12
Hudson, T.J.13
Daly, M.14
Groop, L.15
Lander, E.S.16
-
4
-
-
0030747895
-
Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: No alteration in adipose tissue of obese and NIDDM patients
-
(1997)
Diabetes
, vol.46
, pp. 1319-1327
-
-
Auboeuf, D.1
Rieusset, J.2
Fajas, L.3
Vallier, P.4
Frering, V.5
Riou, J.P.6
Staels, B.7
Auwerx, J.8
Laville, M.9
Vidal, H.10
-
5
-
-
0033599038
-
Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension
-
(1999)
Nature
, vol.402
, pp. 880-883
-
-
Barroso, I.1
Gurnell, M.2
Crowley, V.E.3
Agostini, M.4
Schwabe, J.W.5
Soos, M.A.6
Maslen, G.L.7
Williams, T.D.8
Lewis, H.9
Schafer, A.J.10
Chatterjee, V.K.11
O'Rahilly, S.12
-
8
-
-
0032989265
-
A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat
-
(1999)
Diabetes
, vol.48
, pp. 1415-1424
-
-
Brown, K.K.1
Henke, B.R.2
Blanchard, S.G.3
Cobb, J.E.4
Mook, R.5
Kaldor, I.6
Kliewer, S.A.7
Lehmann, J.M.8
Lenhard, J.M.9
Harrington, W.W.10
Novak, P.J.11
Faison, W.12
Binz, J.G.13
Hashim, M.A.14
Oliver, W.O.15
Brown, H.R.16
Parks, D.J.17
Plunket, K.D.18
Tong, Q.19
Menius, J.A.20
Adkison, K.21
Noble, S.A.22
Willson, T.M.23
more..
-
9
-
-
0031441286
-
Troglitazone action is independent of adipose tissue
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 2900-2908
-
-
Burant, C.F.1
Sreenan, S.2
Hirano, K.3
Tai, T.A.4
Lohmiller, J.5
Lukens, J.6
Davidson, N.O.7
Ross, S.8
Graves, R.A.9
-
14
-
-
0032785335
-
The expression of adhesion molecules on endothelial cells is inhibited by troglitazone through its antioxidant activity
-
(1999)
Cell Adhes. Commun.
, vol.7
, pp. 223-231
-
-
Cominacini, L.1
Garbin, U.2
Pasini, A.F.3
Davoli, A.4
Campagnola, M.5
Rigoni, A.6
Tosetti, L.7
Lo-Cascio, V.8
-
15
-
-
0031595923
-
2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
-
(1998)
Nat. Genet.
, vol.20
, pp. 284-287
-
-
Deeb, S.S.1
Fajas, L.2
Nemoto, M.3
Pihlajamaki, J.4
Mykkanen, L.5
Kuusisto, J.6
Laakso, M.7
Fujimoto, W.8
Auwerx, J.9
-
16
-
-
0033616795
-
Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3951-3956
-
-
Demetri, G.D.1
Fletcher, C.D.2
Mueller, E.3
Sarraf, P.4
Naujoks, R.5
Campbell, N.6
Spiegelman, B.M.7
Singer, S.8
-
18
-
-
0034085884
-
A new thiazolidinedione, NC-2100, which is a weak PPARγ activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice
-
(2000)
Diabetes
, vol.49
, pp. 759-767
-
-
Fukui, Y.1
Masui, S.2
Osada, S.3
Umesono, K.4
Motojima, K.5
-
19
-
-
0029847076
-
Peroxisome proliferator-activated receptor-γ activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells
-
(1996)
Mol. Pharmacol.
, vol.50
, pp. 1087-1094
-
-
Gimble, J.M.1
Robinson, C.E.2
Wu, X.3
Kelly, K.A.4
Rodriguez, B.R.5
Kliewer, S.A.6
Lehmann, J.M.7
Morris, D.C.8
-
26
-
-
0025132245
-
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
-
(1990)
Nature
, vol.347
, pp. 645-650
-
-
Issemann, I.1
Green, S.2
-
29
-
-
0033542091
-
Thiazolidinediones down-regulate plasminogen activator inhibitor type 1 expression in human vascular endothelial cells: A possible role for PPARγ in endothelial function
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.258
, pp. 431-435
-
-
Kato, K.1
Satoh, H.2
Endo, Y.3
Yamada, D.4
Midorikawa, S.5
Sato, W.6
Mizuno, K.7
Fujita, T.8
Tsukamoto, K.9
Watanabe, T.10
-
34
-
-
0032145363
-
Ligand for peroxisome proliferator-activated receptor γ (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo
-
(1998)
Cancer Res.
, vol.58
, pp. 3344-3352
-
-
Kubota, T.1
Koshizuka, K.2
Williamson, E.A.3
Asou, H.4
Said, J.W.5
Holden, S.6
Miyoshi, I.7
Koeffler, H.P.8
-
35
-
-
0033212964
-
PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
-
(1999)
Mol. Cell
, vol.4
, pp. 597-609
-
-
Kubota, N.1
Terauchi, Y.2
Miki, H.3
Tamemoto, H.4
Yamauchi, T.5
Komeda, K.6
Satoh, S.7
Nakano, R.8
Ishii, C.9
Sugiyama, T.10
Eto, K.11
Tsubamoto, Y.12
Okuno, A.13
Murakami, K.14
Sekihara, H.15
Hasegawa, G.16
Naito, M.17
Toyoshima, Y.18
Tanaka, S.19
Shiota, K.20
Kitamura, T.21
Fujita, T.22
Ezaki, O.23
Aizawa, S.24
Kadowaki, T.25
more..
-
36
-
-
0029861097
-
Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 1897-1905
-
-
Law, R.E.1
Meehan, W.P.2
Xi, X.P.3
Graf, K.4
Wuthrich, D.A.5
Coats, W.6
Faxon, D.7
Hsueh, W.A.8
-
43
-
-
0031993322
-
Terminal differentiation of human breast cancer through PPARγ
-
(1998)
Mol. Cell
, vol.1
, pp. 465-470
-
-
Mueller, E.1
Sarraf, P.2
Tontonoz, P.3
Evans, R.M.4
Martin, K.J.5
Zhang, M.6
Fletcher, C.7
Singer, S.8
Dienelman, B.M.9
-
44
-
-
0343855442
-
Effects of ligand activation of peroxisome proliferator-activated receptor γ in human prostate cancer
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 10990-10995
-
-
Mueller, E.1
Smith, M.2
Sarraf, P.3
Kroll, T.4
Aiyer, A.5
Kaufman, D.S.6
Oh, W.7
Demetri, G.8
Figg, W.D.9
Zhou, X.P.10
Eng, C.11
Spiegelman, B.M.12
Kantoff, P.W.13
-
49
-
-
0032520921
-
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 1354-1361
-
-
Okuno, A.1
Tamemoto, H.2
Tobe, K.3
Ueki, K.4
Mori, Y.5
Iwamoto, K.6
Umesono, K.7
Akanuma, Y.8
Fujiwara, T.9
Horikoshi, H.10
Yazaki, Y.11
Kadowaki, T.12
-
55
-
-
0027241856
-
The pathogenesis of atherosclerosis: A perspective for the 1990s
-
(1993)
Nature
, vol.362
, pp. 801-809
-
-
Ross, R.1
-
57
-
-
0031671246
-
Differentiation and reversal of malignant changes in colon cancer through PPARγ
-
(1998)
Nat. Med.
, vol.4
, pp. 1046-1052
-
-
Sarraf, P.1
Mueller, E.2
Jones, D.3
King, F.J.4
DeAngelo, D.J.5
Partridge, J.B.6
Holden, S.A.7
Chen, L.B.8
Singer, S.9
Fletcher, C.10
Spiegelman, B.M.11
-
61
-
-
0031898610
-
PPARγ: Adipogenic regulator and thiazolidinedione receptor
-
(1998)
Diabetes
, vol.47
, pp. 507-514
-
-
Spiegelman, B.M.1
-
62
-
-
0032746173
-
A novel therapy for colitis utilizing PPARγ ligands to inhibit the epithelial inflammatory response
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 383-389
-
-
Su, C.G.1
Wen, X.2
Bailey, S.T.3
Jiang, W.4
Rangwala, S.M.5
Keilbaugh, S.A.6
Flanigan, A.7
Murthy, S.8
Lazar, M.A.9
Wu, G.D.10
-
63
-
-
0034650330
-
Activation of peroxisome proliferator-activated receptor γ does not inhibit IL-6 or TNFα responses of macrophages to lipopolysaccharide in vitro or in vivo
-
(2000)
J. Immunol.
, vol.164
, pp. 1046-1054
-
-
Thieringer, R.1
Fenyk-Melody, J.E.2
Le-Grand, C.B.3
Shelton, B.A.4
Detmers, P.A.5
Somers, E.P.6
Carbin, L.7
Moller, D.E.8
Wright, S.D.9
Berger, J.10
-
65
-
-
12644265334
-
Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 237-241
-
-
Tontonoz, P.1
Singer, S.2
Forman, B.M.3
Sarraf, P.4
Fletcher, J.A.5
Fletcher, C.D.6
Brun, R.P.7
Mueller, E.8
Altiok, S.9
Oppenheim, H.10
Evans, R.M.11
Spiegelman, B.M.12
-
67
-
-
0030977450
-
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 2416-2422
-
-
Vidal-Puig, A.J.1
Considine, R.V.2
Jimenez-Linan, M.3
Werman, A.4
Pories, W.J.5
Caro, J.F.6
Flier, J.S.7
-
69
-
-
0030062325
-
The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones
-
(1996)
J. Med. Chem.
, vol.39
, pp. 665-668
-
-
Willson, T.M.1
Cobb, J.E.2
Cowan, D.J.3
Wiethe, R.W.4
Correa, I.D.5
Prakash, S.R.6
Beck, K.D.7
Moore, L.B.8
Kliewer, S.A.9
Lehmann, J.M.10
-
70
-
-
14444281382
-
Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor γ
-
(1998)
J. Pharmacol. Exp. Ther.
, vol.284
, pp. 751-759
-
-
Young, P.W.1
Buckle, D.R.2
Barrie, C.3
Cantello, C.4
Chapman, H.5
Clapham, J.C.6
Coyle, P.J.7
Haigh, D.8
Hindley, R.M.9
Holder, J.C.10
Kallender, H.11
Latter, A.J.12
Lawrie, K.W.M.13
Mossakowska, D.14
Murphy, G.J.15
Cox, L.R.16
Smith, S.A.17
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