Hormones and testis development and the possible adverse effects of environmental chemicals

Toxicology Letters

Volumn 120, Issue 1-3, 2001, Pages 221-232

  Sharpe, Richard M ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Androgens; Cryptorchidism; Gonocytes; Leydig cells; Oestrogens; Phthalates; Sertoli cells; Sperm counts; Testis cancer

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; ANTIANDROGEN; ENVIRONMENTAL CHEMICAL; ESTRADIOL; ESTRIOL; ESTROGEN; ESTROGEN DERIVATIVE; ESTRONE; INSULIN DERIVATIVE; INSULIN L3; MUELLERIAN INHIBITING FACTOR; PHTHALIC ACID ESTER; TESTOSTERONE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; CRYPTORCHISM; ENVIRONMENTAL EXPOSURE; FETUS DEVELOPMENT; HORMONE DEFICIENCY; HUMAN; HYPOSPADIAS; MALE; MALE INFERTILITY; NONHUMAN; OLIGOSPERMIA; PHENOTYPE; PRENATAL EXPOSURE; PRIORITY JOURNAL; REPRODUCTIVE HEALTH; SEX DIFFERENTIATION; SPERMATOGENESIS; SPERMATOZOON COUNT; TESTIS CANCER; TESTIS DEVELOPMENT; TESTIS DISEASE;

ANIMALS; DIETHYLHEXYL PHTHALATE; FEMALE; FETUS; GONADAL STEROID HORMONES; HUMANS; MALE; SPERM COUNT; SPERMATOGENESIS; TESTIS;

EID: 0035977842     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00298-3     Document Type: Conference Paper

References (47)

1. Is the incidence of hypospadias increasing? Analysis of Finnish hospital discharge data 1970-1994
2. Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood
3. Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: Evidence for stimulatory effects of low estrogen levels
4. Increase in testicular cancer incidence in six European countries: A birth cohort phenomenon
5. Levels of seven urinary phthalate metabolites in a human reference population
6. Effects of environmental synthetic chemicals on thyroid function
7. Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development
8. Mono-(2-ethylhexyl) phthalate suppresses estradiol production independent of FSH-cAMP stimulation in rat granulosa cells
9. Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di (2-ethylhexyl) phthalate and recovery of fertility as adults
10. Critical period for adverse effects on development of the reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy
11. Involvement of insulin-like factor 3 (Insl3) in diethylstilbestrol-induced cryptorchidism
12. Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat: Implications for human risk assessment
13. Environmental antiandrogens: Low doses of the fungicide vinclozolin alter sexual differentiation of the male rat
14. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p, p'-DDE and ketoconazole) and toxic substabces (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethan sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat
15. Comparison of the effects of the 5α-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: Dose-response studies
16. Declining sperm quality: A review of facts and hypotheses
17. The saga of the sperm count decrease in humans and wild and farm animals
18. Quantification of the human Sertoli cell population: Its distribution, relation to germ cell numbers and age-related decline
19. Regional differences in semen quality in Europe
20. Cellular and molecular mechanisms of action of linuron: An antiandrogenic herbicide that produces reproductive malformations in male rats
21. Environmental antiandrogens: Developmental effects, molecular mechanisms, and clinical implications
22. Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats
23. A single dose of di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces Sertoli cell proliferation and decreases cyclin D2 expression
24. Immunolocalisation of androgen receptor to interstitial cells in fetal rat testes and to mesenchymal and epithelial cells of associated ducts
25. Expression of cytochrome P450 17α-hydroxylase/C17-20 lyase in the fetal rat testis is reduced by maternal exposure to exogenous estrogens
26. Polychlorinated biphenyls as hormonally active structural analogues
27. Risk of testicular cancer in subfertile men: Case-control study
28. Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: An anti-androgenic mechanism?
29. Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide
30. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation
31. Cryptorchidism in mice mutant for Insl3
32. A molecular basis for estrogen-induced cryptorchidism
33. Localization of 17β-hydroxysteroid dehydrogenase/17-ketosteroid reductase isoform expression in the developing mouse testis-androstenedione is the major androgen secreted by fetal/neonatal Leydig cells
34. Hypospadias trend in two US surveillance systems
35. Endocrine disruptors and human health-is there a problem? An update
36. Expression of oestrogen receptor beta (ERβ) occurs in multiple cell types, including some germ cells, in the rat testis
37. Regulation of spermatogenesis
38. Environmental oestrogens and male infertility
39. The roles of estrogen in the male
40. Fetal and neonatal hormones and reproductive function of the male in adulthood
41. Interaction of androgens and estrogens in development of the testis and male reproductive tract
42. Effect of neonatal GnRH antagonist administration on Sertoli cell number and testicular development in the marmoset: Comparison with the rat
43. Carcinoma-in-situ of the testis: Possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma
44. Male reproductive health and environmental xenoestrogens
45. Prenatal and perinatal exposures and risk of testicular germ-cell cancer
46. Reproductive toxicity of di-n butylphthalate in a continuous breeding protocol in Sprague-Dawley rats
47. Targeted disruption of the Insl3 gene causes bilateral cryptorchidism