Medical hypothesis: Bifunctional genetic-hormonal pathways to breast cancer

Environmental Health Perspectives

Volumn 105, Issue SUPPL. 3, 1997, Pages 571-576

  Davis, Devra Lee ^a   Telang, Nitin T ^a,b   Osborne, Michael P ^b   Bradlow, H Leon ^b  

^a WORLD RESOURCES INSTITUTE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Breast cancer; Environment; Estradiol metabolism; Genetic and hormonal mechanisms; Xenoestrogen; Xenohormones

Indexed keywords

3 INDOLEMETHANOL; BIOFLAVONOID; ESTRADIOL; ESTROGEN; GENISTEIN; GROWTH FACTOR RECEPTOR; PHYTOESTROGEN; XENOBIOTIC AGENT;

APOPTOSIS; BREAST CANCER; BREAST CARCINOGENESIS; CANCER RISK; CELL PROLIFERATION; CONFERENCE PAPER; DNA REPAIR; DNA STRUCTURE; ESTROGEN METABOLISM; GROWTH REGULATION; PRIORITY JOURNAL;

EID: 0030924760     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.97105s3571     Document Type: Conference Paper

References (45)

1. Kohlmeier L, Rehm J, Hoffmeister H. Lifestyle and trends in worldwide breast cancer rates. Ann NY Acad Sci 609:259-269 (1990).
2. Kosary CL, Gloeckier Ries LA, Miller BA, Hankey BF, Harras A, Edwards BK, eds. SEER Cancer Statistics Review 1973-1991. NIH Publ 94-2789. Bethesda, MD:National Cancer Institute, 1994.
3. Harris JR, Lippman ME, Veronesi U, Willett W. Breast cancer (first of three parts). N Engl J Med 327:319-328 (1992).
4. Pike MC, Spicer DV, Dahmoush L, Press MF. Estrogens, progestogins, normal breast cells, and breast cancer risk. Epidemiol Rev 15:17-35 (1993).
5. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu QY, Cochran C, Bennett LM, Ding W, et al. A strong candidate gene for the breast and ovarian cancer susceptibility gene BRCA1. Science 266:66-71 (1994).
6. Hall JM, Lee MK, Newman B, Morrow JE, Anderson LA, Huey B, King MC. Linkage of early-onset breast cancer to chromosome 17q21. Science 250:1684-1689 (1990).
7. Liehr JG, Ricci MJ, Jefcoate CR, Hannigan EV, Hokanson JA, Zhu BT. 4-hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci USA 92:9220-9224 (1995).
8. Liehr JG, Ricci MJ. 4-hydroxylation of estrogens as marker for human mammary tumors. Proc Natl Acad Sci USA 93:3294-3307 (1996).
9. Aldercreutz H, Gorbach SL, Goldin BR, Woods MN, Dwyer JT, Hockerstedt K, Wahala K, Hase T, Hamalainen E, Foslis T. Estrogen and metabolite levels in women at risk for breast cancer. Proc Am Assoc Cancer Res 35:703 (1994).
10. Toniolo PG, Levitz M, Zeleniuch-Jacquotte A, Banerjec S, Koenig KL, Shore RE, Strax P, Paternack BS. A prospective study of endogenous estrogens and breast cancer in post-menopausal women. J Natl Cancer Inst 87:190-197 (1995)
11. Davis DL, Bradlow, HL Wolff M, Woodruff T, Hoel DG, Anton-Culvier H. Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environ Health Perspect 101:372-377 (1993).
12. Rosner W, Hryb DJ, Khan MS, Nakhla AM, Romas NA. Sex hormone binding globulin: binding to cell membrane and generation of a second messenger. J Androl 3:101-106 (1992).
13. Fishman J, Osborne MP, Telang NT. The role of estrogen in mammary carcinogenesis. Ann NY Acad Sci 768:91-100 (1995).
14. Effects of estradiol, xenoestrogens, and EMF on breast cancer cells. Radiation Res USA 146:444-452 (1996).
15. Dees C, Askari M, Garrett S, Gehrs K, Henley D, Ardies CM, Travis C. Estrogenic and DNA-damaging activity of red no. 3 in human breast cancer cells. Environ Health Perspect, in press.
16. Malins D. Identification of hydroxyl radical-induced lesions in DNA base structure: biomarkers with a putative link to cancer development. J Toxicol Environ Health 40:247-261 (1993).
17. Ames B, Gold LS, Willett WC. The cause and prevention of cancer. Proc Nad Acad Sci USA 92:5258-5265 (1995).
18. Davis DL, Axelrod D, Osborne MP, Telang NT. Environmental influences on breast cancer risk. Sci Med, in press.
19. Nandi S, Guzman RC, Yang J. Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis. Proc Natl Acad Sci USA 92:3650-3657 (1995).
20. Lea OA, Kvinnsland S, Thorsen T. Improved measurement of androgen receptors in human breast cancer. Cancer Res 49:7162-7167 (1989).
21. MacIndoe JH, Etre LA. An antiestrogenic action of androgens in human breast cancer cells. J Clin Endocrinol Metab 53:836-842 (1981).
22. Thomas BS, Bullbrook RD, Harward JL. Urinary androgen metabolites and recurrence rates in early breast cancer. Eur J Clin Oncol 18:447-451 (1982).
23. Aldercreutz H, Mousavi Y, Hockerstedt K. Diet and breast cancer. Acta Oncol 31:175-181 (1992).
24. Bradlow HL, Davis DL, Lin G, Sepkovic D, Tiwari RK. Effects of pesticides on the ratio of 16α/2-hydroxyestrone: a biologic marker of breast cancer risk. Environ Health Perspect 103:147-150 (1995).
25. Nagel SC, vom Saal FS, Thayer, KA, Dhar MG, Boechler M, Welshons WV. Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environ Health Perspect 105:70-76 (1997).
26. Telang NT. Oncogenes, estradiol biotransformation and mammary carcinogenesis. Ann NY Acad Sci 784:277-287 (1996).
27. Telang NT, Suto A, Wong GY, Osborne MP, Bradlow HL. Induction by estrogen metabolite 16α-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. J Natl Cancer Inst 84:634-638 (1992).
28. Suto A, Bradlow HL, Wong GYC, Osborne MP, Telang NT. Experimental down-regulation of intermediate biomarkers of carcinogenesis in mouse mammary epithelial cells. Breast Cancer Res Treat 27:193-202 (1993).
29. Telang NT, Suto A, Wong GY, Bradlow HL, Osborne MP. Genotoxic damage and aberrant proliferation by estrogen metabolites in mammary epithelial cells [Abstract]. Proc Am Assoc Cancer Res 33:278 (1992).
30. Osborne MP, Bradlow HL, Wong GYC, Telang NT. Up-regulation of estradiol C16α-hydroxylation in human breast tissue: a potential biomarker for breast cancer risk. J Natl Cancer Inst 85:1917-1920 (1993).
31. Osborne MP, Karmali RA, Bradlow HL, Hershcopf RJ, Kourides IA, Williams WR, Rosen PP, Fishman J. Omega-3 fatty acids: modulation of estrogen metabolism and potential for breast cancer prevention. Cancer Invest 6:629-631 (1988).
32. Bradlow HL, Hershcopf RJ, Martucci CP, Fishman J. Estradiol 16α-hydroxylation correlates with mammary tumor incidence and presence of murine mammary tumor virus: a possible model for hormonal etiology of breast cancer in human. Proc Natl Acad Sci USA 82:6295-6299 (1985).
33. Weisz A, Bresciani F. Estrogen regulation of protooncogenes coding for nuclear proteins. Crit Rev Oncog 4:361-388 (1993).
34. Swaneck GE, Fishman J. Covalent binding of the endogenous estrogen 16α-hydroxyestrone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization. Proc Natl Acad Sci USA 85:7831-7835 (1988).
35. Goldin BR, Gorbach SL. Effect of diet on the plasma levels, metabolism and excretion of estrogens. Am J Nutrition 48:787-790 (1988;)
36. Weisz J, Bui QD, Roy D, Liehr JG. Elevated 4-hyroxylation of estradiol by hamster kidney microsomes: a potential pathway of metabolic activation of estrogens. Endocrinology 131:655-661 (1992).
37. Han X, Liehr JG. Microsome-mediated 8-hydroxylation of guanine bases of DNA by steroid estrogens: correlation of DNA damage by free radicals with metabolic activation to quinones. Carcinogenesis 16:2571-2574 (1995).
38. Li JJ, Li SA. Estrogen carcinogenesis in hamster tissues: a critical review. Endocrine Rev 11:524-531 (1990).
39. Tiwari RK, Guo L, Bradlow HL, Telang NT, Osborne MP. Selective responsiveness of breast cancer cells to indole-3-carbinol, a chemopreventive agent. J Natl Cancer Inst 86:126-131 (1994).
40. Li D, Wang M, Dhingra K, Hittleman WN. Aromatic DNA adducts in adjacent tissues of breast cancer patients: clues to cancer etiology. Cancer Res 56:287-293 (1996).
41. Aylsworth CF. Effects of lipids on gapjunctionally mediated intercellular communication: possible role in the promotion of tumorigenesis by dietary fat. In: Dietary Fats and Cancer (Ip C, Birt DF, Rogers AE, Metlin C, eds). New York:Alan R. Liss, 1986;607-622.
42. Kang KS, Wilson MR, Hayashi T, Chang CC, Trosko JE. Inhibition of gapjunctional communication in normal human breast epithelial cells after treatment with pesticides, PCB, PBB alone or in mixture. Environ Health Perspect 104:192-200 (1996).
43. Coleman, RA. Identifying xenobiotic acids that can form PKC-activating diacylglycerols. J Lipid Res USA 36:2493-2503 (1995).
44. .Clemmesen J. Carcinoma of the breast: results from statistical research. Br J Radiol 21:583-590 (1948).
45. Colditz GA. Fat, estrogens and the time frame for prevention of breast cancer (editorial). Epidemiology 6:207-208 (1995).