Molecular pathways of protein synthesis inhibition during brain reperfusion: Implications for neuronal survival or death

Journal of Cerebral Blood Flow and Metabolism

Volumn 22, Issue 2, 2002, Pages 127-141

  DeGracia, Donald J ^a   Kumar, Rita ^a   Owen, Cheri R ^a   Krause, Gary S ^a   White, Blaine C ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain ischemia; Brain reperfusion; eIF2; eIF2 ; eIF4E; eIF4G; IRE1; mRNA selection; PERK; Protein synthesis inhibition; Unfolded protein response

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM ION; CASPASE; INITIATION FACTOR; INITIATION FACTOR 2; INITIATION FACTOR 2ALPHA; INITIATION FACTOR 4; INITIATION FACTOR 4E; INITIATION FACTOR 4G; INOSITOL; MESSENGER RNA; PHOSPHOTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALPHA CHAIN; APOPTOSIS; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CELL SURVIVAL; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; INTERNAL RIBOSOME ENTRY SITE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; REPERFUSION INJURY; REVIEW; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; TRANSLATION INITIATION;

EID: 0036167612     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200202000-00001     Document Type: Review

References (141)

1. Purification and characterization of guanine nucleotide-exchange factor, eIF-2B, and p37 calmodulin-binding protein from calf brain
2. s6 kinase after transient focal cerebral ischaemia in mice
3. Regional impairment of protein synthesis following brief cerebral ischemia in the gerbil
4. Rapid production of diacylglycerol enriched in arachidonate and stearate during early brain ischemia
5. 2+ pumps in the brain
6. 2+-pump isoform SERCA3a is more resistant to superoxide damage than SERCA2b
7. Ischemic preconditioning and brain tolerance: Temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression
8. Dynamic interaction of GRP78 and ER stress transducers in the unfolded-protein response
9. Alterations in an IRE1-RNA complex in the mammalian unfolded protein response
10. Regulation of translational initiation during cellular responses to stress
11. Accommodation of protein synthesis to chronic deprivation of intracellular sequestered calcium. A putative role for GRP78
12. Phosphorylation of the α subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischemia in the rat
13. The intraischemic and early reperfusion changes of protein synthesis in the rat brain: eIF-2α kinase activity and role of initiation factors eIF-2α and eIF-4E
14. The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein
15. Induction of caspase-3 like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
16. Heme-regulated eIF2α kinase
17. 134.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage
18. Initiation of Apaf-1 translation by internal ribosome entry
19. 2+ regulation of interactions between endoplasmic reticulum chaperones
20. Mechanism of activation of the heme-stabilized translational inhibitor of reticulocyte lysates by calcium ions and phospholipid
21. Global brain ischemia and reperfusion: Modifications in eukaryotic initiation factors are associated with inhibition of translation initiation
22. Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2α
23. Eukaryotic initiation factor 2α (eIF2α kinase and phosphatase activity during postischemic brain reperfusion
24. Met ternary complexes
25. Activation of MYD116 (GADD34) expression following transient forebrain ischemia of rat: Implications for a role of disturbances of endoplasmic reticulum calcium homeostasis
26. Effect of nitric oxide on endoplasmic reticulum calcium homeostasis, protein synthesis and energy metabolism
27. Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response
28. Arachidonic acid stimulates intracellular calcium mobilization and regulates protein synthesis, ATP levels, and mucin secretion in submandibular gland cells
29. DNA damage-inducible transcripts in mammalian cells
30. Conservation and divergence of the yeast and mammalian unfolded protein response
31. eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
32. Control of translation initiation in animals
33. 2+ pump isoform SERCA3 is more resistant than SERCA2b to peroxide
34. p67 transcription regulates translation in serum-starved and mitogen-activated KRC-7 cells
35. Correlation between protein and mRNA abundance in yeast
36. Transcription factor ATF cDNA clones: An extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers
37. Expression of p68 protein kinase as recognized by the monoclonal antibody TJ4C4 during human fetal development
38. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
39. Regulated translation initiation controls stress-induced gene expression in mammalian cells
40. Perk is essential for translational regulation and cell survival during the unfolded protein response
41. -/- mice reveals a role for translational control in secretory cell survival
42. (1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase
43. Internal ribosome entry sites in eukaryotic mRNA molecules
44. A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation
45. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury
46. Mammalian GADD34, an apoptosis- and DNA damage-inducible gene
47. Disturbances of cerebral protein synthesis and ischemic cell death
48. Stress-induced inhibition of protein synthesis initiation: Modulation of initiation factor 2 and guanine nucleotide exchange factor activities following transient ischemia in the rat
49. Protein aggregation after transient cerebral ischemia
50. Protein aggregation after focal brain ischemia and reperfusion
51. Inhibition of rabbit reticulocyte lysate protein synthesis by heavy metal ions involves the phosphorylation of the α-subunit of the eukaryotic initiation factor 2
52. Expression of GADD34 and PCNA in focal cerebral ischemia
53. Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress
54. S6K in transient focal ischemia
55. Microarray analysis of hippocampal gene expression in global cerebral ischemia
56. Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray
57. Facilitated recovery from postischemic suppression of protein synthesis in the gerbil brain with ischemic tolerance
58. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
59. Double-stranded RNA-activated protein kinase PKR
60. Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response
61. Protein synthesis in postischemic rat brain: A two-dimensional electrophoretic analysis
62. Regulation of translation initiation in mammalian cells by amino acids
63. Protein synthesis in the cat brain after prolonged cerebral ischemia
64. The promoter region of the yeast KAR2 (GRP78) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum
65. Neuroprotective nitric oxide synthase inhibitor reduces intracellular calcium accumulation following transient global ischemia in the gerbil
66. Suppression of protein synthesis in the reperfused brain
67. eIF2α phosphorylation following cerebral ischemia in HRI, eNOS, and nNOS knockout mice
68. Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK
69. Characterization of apoptosis genes associated with NMDA-mediated cell death in the adult rat retina
70. Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated eIF-4E
71. Phosphorylase phosphatase: New horizons for an old enzyme
72. Establishment of a chinese hamster ovary cell line that expresses GRP78 antisense transcripts and suppresses A23187 induction of both GRP78 and GRP94f
73. ATF6 is a transcription activator of the endoplasmic reticulum stress element: Thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1
74. Ischemia cell death in brain neurons
75. Levels, phosphorylation status and cellular localization of translational factor eIF2 in gastrointestinal carcinomas
76. Increased expression of mRNA encoding calbindin-D28K, the glucose-regulated proteins, or the 72 kDa heat-shock protein in three models of acute CNS injury
77. Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells
78. Possible mechanisms involved in the down-regulation of translation during transient global ischemia in the rat brain
79. Ischemia-induced inhibition of the initiation factor 2α phosphatase activity in the rat brain
80. Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells
81. Mouse lymphoma cells destined to undergo apoptosis in response to thapsigargin treatment fail to generate a calcium-mediated grp78/grp94 stress response
82. GADD153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
83. 2+ ATPase. Relationship between global protein synthesis and expression and translation of individual genes
84. Characterization of mouse 1RE1α: Cloning, mRNA localization in the brain, and functional analysis in a neural cell line
85. Comprehensive polypeptide analysis of microdissected rat brain areas: Combining 2-dimensional gel electrophoresis with 2-dimensional HPLC and immunoanalysis and sequencing procedures
86. Differential requirements for caspase-8 activity in the mechanism of phosphorylation of eIF2α, cleavage of eIF4G1, and signaling events associated with the inhibition of protein synthesis in apoptotic Jurkat T cells
87. Eukaryotic initiation factor 4E degradation during brain ischemia
88. Calpain mediates eukaryotic initiation factor 4G degradation during global brain ischemia
89. Calpain activity in the rat brain after transient forebrain ischemia
90. Pausing to decide
91. A role for presenilin-1 in nuclear accumulation of IRE1 fragments and induction of the mammalian unfolded protein response
92. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α
93. Erp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin
94. Cell death, calcium mobilization, and immunostaining for phosphorylated eukaryotic initiation factor 2-alpha (eIF2α) in neuronally-differentiated NB-104 cells: Arachidonate and radical-mediated injury mechanisms
95. Characterization of the eIF2-associated protein p67 during brain ischemia and reperfusion
96. Global cerebral ischemia induces eIF2α phosphorylation throughout the entire brain
97. Initiation of protein synthesis in eukaryotic cells
98. Tissue distribution of heine-regulated eIF-2 kinase determined by monoclonal antibodies
99. 2+ ATPase
100. 2+ ATPase
101. Disturbances of calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischemic-cell damage
102. Role of calcium in neuronal cell injury: Which subcellular compartment is involved?
103. Activation of GADD 153 expression through transient cerebral ischemia: Evidence that ischemia causes endoplasmic reticulum dysfunction
104. Erp72 expression activated by transient cerebral ischemia or disturbance of neuronal endoplasmic reticulum calcium stores
105. Intracellular signaling from the endoplasmic reticulum to the nucleus: The unfolded protein response in yeast and mammals
106. p70 S6 kinase: An enigma with variations
107. Ischemia-induced inhibition of active calcium transport into gerbil brain microsomes: Effect of anesthetics and models of ischemia
108. Stroke genomics: Approaches to identify, validate, and understand ischemic stroke gene expression
109. Activity of protein phosphatases against initiation factor-2 and elongation factor-2
110. The message is in the translation
111. Immunolocalization of calpain-1-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain
112. PERK and translational control by stress in the endoplasmic reticulum
113. The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2
114. The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex
115. Translational control is required for the unfolded protein response and in vivo glucose homeostasis
116. Identification and characterization of pancreatic eukaryotic initiation factor 2α-subunit kinase, PEK, involved in translational control
117. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
118. Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage
119. A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2α
120. Protein folding in the ER
121. Insulin induces dephosphorylation of eukaryotic initiation factor 2α and restores protein synthesis in vulnerable hippocampal neurons after transient brain ischemia
122. 2-terminal kinase and p38 mitogen-activated protein kinase after transient forebrain ischemia in mice
123. Persistent inhibition of protein synthesis precedes delayed neuronal death in post-ischemic gerbil hippocampus
124. Functional and genomic analysis reveals an essential coordination between the unfolded protein response and ER-associated degradation
125. CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins
126. The heme-regulated eukaryotic initiation factor 2α kinase. A potential regulatory target for control of protein synthesis by diffusible gases
127. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
128. Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia
129. Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153)
130. Cloning of mammalian Ire1 reveals diversity in the ER stress responses
131. Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response
132. The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and transphosphorylation of Ire1p (Ern1p) are required for kinase activation
133. Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase
134. Quantitative analysis of peptide and protein changes in ischemic hippocampal tissue by HPLC
135. Brain ischemia and reperfusion: Molecular mechanisms of neuronal injury
136. Amino acid sequence of the human protein synthesis initiation factor eIF-4 γ
137. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
138. Activation of caspase-12, an endoplasmic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
139. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: Suppression of oxidative stress and stabilization of calcium homeostasis
140. Brain regulation of transcription factor C/ATF by the cAMP signal activation in hippocampal neurons, and molecular interaction of C/ATF with signal integrator CBP/p300
141. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum