Alterations in an IRE1-RNA complex in the mammalian unfolded protein response

Journal of Cell Science

Volumn 114, Issue 17, 2001, Pages 3207-3212

  Bertolotti, A ^a   Ron, D ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endoplasmic reticulum; Protein kinase; Ribonuclease; RNA processing; Signal transduction

Indexed keywords

ENDONUCLEASE; ISOTOPE; MEMBRANE PROTEIN; PROTEIN KINASE; RNA;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; GENE ISOLATION; HUMAN; HUMAN CELL; IN VIVO STUDY; ISOTOPE LABELING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN RNA BINDING; RAT; RNA STRUCTURE; STRESS; ULTRAVIOLET RADIATION;

ANIMALS; CELLS, CULTURED; DACTINOMYCIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; HUMANS; MEMBRANE PROTEINS; PRECIPITIN TESTS; PROTEIN FOLDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RATS; RNA; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS; TIME FACTORS; TRANSFECTION;

EID: 0034800509     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Dynamic interaction of BiP and the ER stress transducers in the unfolded protein response
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4. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response
5. Regulated translation initiation controls stress-induced gene expression in mammalian cells
6. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
7. Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response
8. ATF6 as a transcription activator of the endoplasmic reticulum stress element: Thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1
9. Tripartite management of unfolded proteins in the endoplasmic reticulum
10. A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus
11. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response
12. Genome-wide location and function of DNA binding proteins
13. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response
14. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
15. Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier
16. The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response
17. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
18. Coupling of stress in the endoplasmic reticulum to activation of JNK protein kinases by transmembrane protein kinase IRE1
19. Cloning of mammalian Ire1 reveals diversity in the ER stress responses