Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain

Biochemical Journal

Volumn 357, Issue 3, 2001, Pages 819-826

  Martin de la Vega C ^a   Burda, J ^a   Nemethova, M ^a   Quevedo, C ^a   Alcazar A ^a   Martin M E ^a   Danielisova, V ^a   Fando, J L ^a   Salinas, M ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Cerebral ischaemia; Initiation factors; Protein phosphorylation; Protein synthesis; Ribosomal protein S6 kinase

Indexed keywords

NEUROLOGY; PATHOLOGY; POLYPEPTIDES; PROTEINS;

EUCARYOTIC INITIATION FACTOR (EIF);

BRAIN;

BINDING PROTEIN; INITIATION FACTOR 2; INITIATION FACTOR 4E; RIBOSOME PROTEIN; S6 KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; REPERFUSION; TRANSLATION REGULATION;

ANIMALS; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; EUKARYOTIC INITIATION FACTOR-2; EUKARYOTIC INITIATION FACTOR-2B; EUKARYOTIC INITIATION FACTOR-4E; EUKARYOTIC INITIATION FACTOR-4G; ISCHEMIC ATTACK, TRANSIENT; PEPTIDE INITIATION FACTORS; PHOSPHOPROTEINS; PHOSPHORYLATION; POLYRIBOSOMES; PROTEIN BIOSYNTHESIS; RATS; RATS, WISTAR; REPERFUSION; RIBOSOMAL PROTEIN S6 KINASES;

EID: 0035425221     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3570819     Document Type: Article

References (35)

1. Disturbances of cerebral protein synthesis and ischemic cell death
2. Reprogramming of gene expression after ischemia
3. Ischemic cell death in brain neurons
4. Mechanisms of cerebral ischemic damage
5. The intraischemic and early reperfusion changes of protein synthesis in the rat brain. eIF-2α kinase activity and role of initiation factors eIF-2α and eIF-4E
6. Calpain mediates eukaryotic initiation factor 4G degradation during global brain ischemia
7. Regional protein synthesis in rat brain following acute hemispheric ischemia
8. Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus
9. The effect of ischemia and recirculation on protein synthesis in the rat brain
10. Changes in polysomes from ischemic spinal cord
11. The pathway and mechanism of eukaryotic protein synthesis
12. Translational control during heat shock
13. Calcium mobilization by ryanodine promotes the phosphorylation of initiation factor 2α subunit and inhibits protein synthesis in cultured neurons
14. Inhibition of protein synthesis by nitric oxide correlates with cytostatic activity: Nitric oxide induces phosphorylation of initiation factor eIF-2α
15. Phosphorylation of the α subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischaemia in the rat
16. Global brain ischemia and reperfusion: Modifications in eukaryotic initiation factors associated with inhibition of translation initiation
17. Stress-induced inhibition of protein synthesis initiation-modulation of initiation factor-2 and guanine nucleotide exchange factor activities following transient cerebral ischemia in the rat
18. Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2α
19. eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
20. S6 phosphorylation and signal transduction
21. Purification and characterisation of guanine-nucleotide-exchange factor, eIF-2B and p37 calmodulin-binding protein from calf brain
22. A new model of bilateral hemispheric ischemia in unanesthetized rat
23. A modified four-vessel occlusion model for inducing incomplete forebrain ischemia in rats
24. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
25. Effect of streptozotocin diabetes on polysomal aggregation and protein synthesis rate in the liver of pregnant rats and their offspring
26. Ischemia-induced inhibition of the initiation factor 2α phosphatase activity in the rat brain
27. Ultrastructural localisation of phosphorylated eIF2α [eIF2α(P)] in rat dorsal hippocampus during reperfusion
28. Initiation of protein synthesis and heat-shock protein-72 expression in the rat brain following severe insulin-induced hypoglycemia
29. Ischemia-induced phosphorylation of initiation factor 2 in differentiated PC 12 cells. Role for initiation factor 2 phosphatases
30. Altered gene expression in brain ischemia
31. PHAS/4E-BPs as regulators of mRNA translation and cell proliferation
32. An analysis of vertebrate mRNA sequences: Intimations of translational control
33. Ischaemia induces changes in the association of the binding protein 4E-BP1 and eukaryotic initiation factor (eIF) 4G to eIF4E in differentiated PC12 cells
34. Changes in cerebral energy metabolism and calcium levels in relation to delayed neuronal death alter ischemia
35. Progressive loss of messenger RNA and delayed neuronal death following transient cerebral ischemia in gerbils