Stroke genomics: Approaches to identify, validate, and understand ischemic stroke gene expression

Journal of Cerebral Blood Flow and Metabolism

Volumn 21, Issue 7, 2001, Pages 755-778

  Read, Simon J ^a,b   Parsons, Andrew A ^a,b   Harrison, David C ^a,b   Philpott, Karen ^a,b   Kabnick, Karen ^a,b   O'Brien, Shawn ^a,b   Clark, Steven ^a,b   Brawner, Mary ^a,b   Bates, Stewart ^a,b   Gloger, Israel ^a,b   Legos, Jeffrey J ^a,b   Barone, Frank C ^a,b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b NONE

Author keywords

Differential display; Gene expression; MCAO; Microarray gridding; Neurodestructive genes; Neuroprotective genes; Protein; Representative differential analysis; Stroke; Stroke in evolution; Suppressive subtractive hybridization; Target validation; Transcription; Translation

Indexed keywords

BRAIN INJURY; CEREBROVASCULAR ACCIDENT; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENETIC RISK; HEREDITY; HUMAN; NEUROPROTECTION; PRIORITY JOURNAL; REVIEW; RNA TRANSLATION; SEQUENCE ANALYSIS; STROKE;

EID: 0034958605     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200107000-00001     Document Type: Review

References (201)

1. Isolation of an ischemia-induced gene and early disturbance of mitochondrial DNA expression after transient forebrain ischemia
2. Expanding the window for thrombolytic therapy in acute stroke. The potential role of acute MRI for patient selection
3. Frequency of resistance to activated protein C due to factor V mutation in young patients with ischemic stroke
4. Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain
5. Notch signaling: Cell fate control and signal integration in development
6. Magnetic resonance imaging of acute stroke
7. Ischemic preconditioning and brain tolerance: Temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression
8. Inflammatory mediators and stroke: New opportunities for novel therapeutics
9. Application of a subtraction hybridization technique involving photoactivatable biotin and organic extraction to solution hybridization analysis of genomic DNA
10. Time-related neuronal changes following middle cerebral artery occlusion: Implications for therapeutic intervention and the role of calpain
11. Molecular characterisation by subtractive hybridisation of the Zea Longa model of permanent middle cerebral artery occlusion in the rat. Identification of novel gene expression following experimental ischemia
12. Prepro-thyrotropin-releasing hormone 178-199 exerts partial protection against cerebral ischemia in adult rats
13. A study of twins and stroke
14. Subarachnoid haemorrhage in first and second degree relatives of patients with subarachnoid
15. Genes encoding atrial and brain natriuretic peptides as candidates for sensitivity to brain ischemia in stroke-prone hypertensive rats
16. Reperfusion after thrombolytic therapy of embolic stroke in the rat: Magnetic resonance and biochemical imaging
17. Induction of interleukin-1 beta mRNA after focal cerebral ischaemia in the rat
18. Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat
19. Efficient expression of the vascular endothelial growth factor gene in vitro and in vivo, using an adeno-associated virus vector
20. Long-term phenotypic correction of rodent hemiparkinsonism by gene therapy using genetically modified myoblasts
21. Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins
22. Factor XIII Val 34 Leu: A novel association with primary intracerebral hemorrhage
23. Autosomal dominant migraine with MRI white-matter abnormalities mapping to the CADASIL locus
24. Patterns of MRI lesions in CADASIL
25. Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia
26. Stress proteins and tolerance to focal cerebral ischemia
27. Ischemic tolerance in the brain
28. MELAS: Clinical features, biochemistry, and molecular genetics
29. Development of tissue damage, inflammation and resolution following stroke: An immunohistochemical and quantitative planimetric study
30. Cervene (Nalmefene) in acute ischemic stroke: Final results of a phase III efficacy study. The Cervene Stroke Study Investigators
31. Focal ischemia causes an extensive induction of immediate early genes that are sensitive to MK-801
32. Genetic polymorphisms of factor VII are not associated with arterial thrombosis
33. Prevalence of apolipoprotein E phenotypes in ischemic cerebrovascular disease. A case-control study
34. Cerebral infarction after middle cerebral artery occlusion in progenies of spontaneously stroke-prone and normal rats
35. Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27
36. An integrated analysis of the progression of cell responses induced by permanent focal middle cerebral artery occlusion in the rat
37. Why do neuroprotective drugs work in animals but not humans?
38. Diffusion-weighted MRI of infarct growth in a rat photochemical stroke model: Effect of lubeluzole
39. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
40. Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients
41. CADASIL in a North American family: Clinical, pathologic, and radiologic findings
42. Identification of a key recombinant narrows the CADASIL gene region to 8 cM and argues against allelism of CADASIL and familial hemiplegic migraine
43. The phenotypic spectrum of CADASIL: Clinical findings in 102 cases
44. Functional rewiring of brain and spinal cord after injury: The three Rs of neural repair and neurological rehabilitation
45. Genes and hypertension: From gene mapping in experimental models to vascular gene transfer strategies
46. Genetic susceptibility and ischemic stroke
47. Osteopontin and its integrin receptor alpha (v)beta3 are upregulated during formation of the glial scar after focal stroke
48. Recommendations for standards regarding preclinical neuroprotective and restorative drug development
49. Role of molecular biology in strategies to discover novel targets for drug discovery
50. Activated protein C resistance in ischemic stroke not due to factor V arginine506->glutamine mutation
51. Further evolution toward effective therapy for acute ischemic stroke
52. Activation of arc, a putative "effector" immediate early gene, by cocaine in rat brain
53. Activation of nuclear factor-kappaB in the rat brain after transient focal ischemia
54. Transient expression of the mitogen-activated protein kinase phosphatase MKP-1 (3CH134/ERP1) in the rat brain after limbic epilepsy
55. Initial sequencing and analysis of the human genome
56. A novel method for real time quantitative RT-PCR
57. A comparison of the early development of ischemic damage following permanent middle cerebral artery occlusion in rats as assessed using magnetic resonance imaging and histology
58. Adenovirus-mediated VEGF(121) gene transfer stimulates angiogenesis in normoperfused skeletal muscle and preserves tissue perfusion after induction of ischemia
59. Susceptibility to cerebral infarction in the stroke-prone spontaneously hypertensive rat is inherited as a dominant trait
60. Evolution of acute focal cerebral ischaemia in rats observed by localized 1H MRS, diffusion-weighted MRI, and electrophysiological monitoring
61. The use of quantitative RT-PCR to measure mRNA expression in a rat model of focal ischemia-caspase-3 as a case study
62. TR3 death receptor expression in the normal and ischemic brain
63. Caspase mRNA expression in a rat model of focal cerebral ischemia
64. Genetics and ischemic stroke
65. Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats
66. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: Study of two American families with predominant dementia
67. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): Current concepts
68. Expression of zinc finger immediate early genes in rat brain after permanent middle cerebral artery occlusion
69. Periinfarct depolarizations
70. The study of human twins in medical research
71. Identifying differences in mRNA expression by representational difference analysis of cDNA
72. Functional assessments in mice and rats after focal stroke
73. Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia
74. Molecular pathology of cerebral ischemia: Delayed gene expression and strategies for neuroprotection
75. Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice
76. The region responsible for stroke on chromosome 4 in the stroke-prone spontaneously hypertensive rat
77. Sensitivity to cerebral ischemic insult in a rat model of stroke is determined by a single genetic locus
78. Magnetic resonance imaging indexes of therapeutic efficacy of recombinant tissue plasminogen activator treatment of rat at 1 and 4 hours after embolic stroke
79. Parental history of cardiovascular disease and risk of stroke. A prospective follow-up of 14371 middle-aged men and women in Finland
80. A gene for familial hemiplegic migraine maps to chromosome 19
81. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
82. Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients
83. Notch signalling pathway and human diseases
84. Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects
85. Epidemiologic assessment of the role of blood pressure in stroke. The Framingham study
86. Expression of an ADP-ribosylation factor like gene, ARF4L, is induced after transient forebrain ischemia in the gerbil
87. The apolipoprotein E and beta-fibrinogen G/A-455 gene polymorphisms are associated with ischemic stroke involving large-vessel disease
88. Suppression of proteasome C2 contralateral to ischemic lesions in rat brain
89. Family history of stroke as an independent predictor of ischemic heart disease in men and stroke in women
90. Familial aggregation of stroke. The Framingham Study
91. Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat
92. "Ischemic tolerance" phenomenon found in the brain
93. "Ischemic tolerance" phenomenon detected in various brain regions
94. Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke
95. Relationship between diffusion-weighted MR images, cerebral blood flow, and energy state in experimental brain infarction
96. A modified rat model of middle cerebral artery thread occlusion under electrophysiological control for magnetic resonance investigations
97. Altered gene expression in brain ischemia
98. Experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats which recirculation can be introduced in the ischemic area
99. Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage
100. Arg506Gln factor V mutation (factor V Leiden) in patients with ischemic cerebro-vascular disease and survivors of myocardial infarction
101. Evidence for cardioembolic stroke in a case of Kearns-Sayre syndrome
102. Accumulation of somatic nucleotide substitutions in mitochondrial DNA associated with the 3243 A-to-G tRNA(leu)(UUR) mutation in encephalomyopathy and cardiomyopathy
103. Are animal models of diabetes relevant to the study of the genetics of non-insulin-dependent diabetes in humans?
104. Are cerebrovascular factors involved in Alzheimer's disease?
105. Reconditioning: State of the art myocardial protection
106. Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 121
107. Evolution of photochemically induced focal cerebral ischemia in the rat. Magnetic resonance imaging and histology
108. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S 182 Alzheimer's disease gene
109. Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats - Correlation with histopathology
110. Familial history of stroke and stroke risk. The Family Heart Study
111. The molecular basis of glucocorticoid-remediable aldosteronism, a Mendelian cause of human hypertension
112. High density synthetic oligonucleotide arrays
113. Representational difference analysis: Finding the differences between genomes
114. Cytokine-induced neutrophil chemoattractant mRNA expressed in cerebral ischemia
115. Interleukin-1β expression in ischemic rat cortex
116. Tumor necrosis factor-alpha expression in ischemic neurons
117. Expression monitoring by hybridization to high-density oligo-nucleotide arrays
118. Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat
119. Reversible middle cerebral artery occlusion without craniectomy in rats
120. Familial Sneddon's syndrome
121. No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke
122. Variable distribution of mutant mitochondrial DNAs (tRNA(Leu[3243])) in tissues of symptomatic relatives with MELAS: The role of mitotic segregation
123. Ischemic damage and subsequent proliferation of oligodendrocytes in focal cerebral ischemia
124. Deletion polymorphism in the angiotensin-converting enzyme gene in patients with a history of ischemic stroke
125. Prevalence of apolipoprotein E alleles in healthy subjects and survivors of ischemic stroke: An Italian Case-Control Study
126. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia
127. CD95 ligand (Fas-L/APO-IL) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons
128. The use of TaqMan RT-PCR assays for semi-quantitative analysis of gene expression in CNS tissues and disease models
129. Genetic predisposition to stroke in spontaneously hypertensive rats
130. Polymorphism of angiotensin converting enzyme, angiotensinogen, and apolipoprotein E genes in a Japanese population with cerebrovascular disease
131. Methylenetetrahydrofolate reductase gene polymorphism: Relation to blood pressure and cerebrovascular disease
132. Serial MRI after transient focal cerebral ischemia in rats: Dynamics of tissue injury, blood-brain barrier damage, and edema formation
133. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage
134. Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia
135. Public perception of stroke warning signs and knowledge of potential risk factors
136. Acute stroke therapy: Issues for translating pre-clinical neuroprotection to therapeutic reality
137. Lipoprotein and apolipoprotein profile in men with ischemic stroke. Role of lipoprotein(a), triglyceride-rich lipoproteins, and apolipoprotein E polymorphism
138. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
139. Genetics of stroke-a review
140. Interleukin-1 receptor antagonist inhibits ischemic and excitotoxic neuronal damage in the rat
141. Neuromagnetic recordings and magnetic brain stimulation in the evaluation of sensorimotor hand area interhemispheric differences: Normative, experimental and patients' data
142. An integrative neuroimaging approach to restorative neurology
143. Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease
144. The gene encoding atrial natriuretic peptide and the risk of human stroke
145. Differential brain atrial natriuretic peptide expression co-segregates with occurrence of early stroke in the stroke-prone phenotype of the spontaneously hypertensive rat
146. Altered structure, regulation and function of the gene encoding the atrial natriuretic peptide in the stroke-prone spontaneously hypertensive rat
147. Endothelial changes in muscle and skin biopsies in patients with CADASIL
148. Mitochondrial DNA mutations at nucleotide positions 3243 and 3271 in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes: A comparative study
149. Quantitative monitoring of gene expression patterns with a complementary DNA microarray
150. Vascular risk factors in dementia
151. Pixel-based image analysis of HSP70, GADD45 and MAP2 mRNA expression after focal cerebral ischemia: Hemodynamic and histological correlates
152. Differential changes of bax, caspase-3 and p21 mRNA expression after transient focal brain ischemia in the rat
153. Molecular approach to assessing the genetic risk of cerebral infarction: Deletion polymorphism in the gene encoding angiotensin 1-converting enzyme
154. Multiple molecular penumbras after focal cerebral ischemia
155. Adeno-associated virus vector-mediated bcl-2 gene transfer into post-ischemic gerbil brain in vivo: Prospects for gene therapy of ischemia-induced neuronal death
156. Vascular aspects in Alzheimer's disease
157. Parallel gene expression monitoring using oligonucleotide probe arrays of multiple transcripts with an animal model of focal ischemia
158. Hereditary multi-infarct dementia
159. Altered patterns of gene expression in response to myocardial infarction
160. Transcription factor nuclear factor-kappa B is activated in neurons after focal cerebral ischemia
161. Rising stroke rates spur efforts to identify risks, prevent disease
162. Immunohistochemical detection of leukemia inhibitory factor after focal cerebral ischemia in rats
163. Induction of macrophage inflammatory protein MIP-1 alpha mRNA on glial cells after focal cerebral ischemia in the rat
164. Focal cerebral ischaemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion
165. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12
166. Induction of SPI-3 mRNA, encoding a serine protease inhibitor, in gerbil hippocampus after transient forebrain ischemia
167. Expression of zinc transporter gene, ZnT-1, is induced after transient forebrain ischemia in the gerbil
168. A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation
169. Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia
170. T2- and diffusion-weighted magnetic resonance imaging of a focal ischemic lesion in rat brain
171. CADASIL: Hereditary arteriopathy leading to multiple brain infarcts and dementia
172. Subtracted differential display: Genes with amphetamine-altered expression patterns include calcineurin
173. Concomitant cortical expression of TNF-alpha and IL-1 beta mRNAs follows early response gene expression in transient focal ischemia
174. Monocyte chemoattractant protein-1 (MCP-1) mRNA expression in rat ischemic cortex
175. Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage
176. Transforming growth factor ß1, exhibits delayed gene expression following focal cerebral ischemia
177. Expression of interleukin 6, c-fos and zif268 mRNA in rat ischemic cortex
178. Interleukin-1 receptor and receptor antagonist gene expression after focal stroke in rats
179. Subtractive cloning identifies tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) increased gene expression in focal stroke
180. Prolonged expression of interferon inducible protein-10 in ischemic cortex after permanent occlusion of the middle cerebral artery in the rat
181. Delayed expression of osteopontin after focal stroke in the rat
182. Use of suppression subtractive hybridization strategy for discovery of increased tissue inhibitor of matrix metalloproteinase-1 gene expression in brain ischemic tolerance
183. Molecular cloning and expression of the rat monocyte chemotactic protein-3 gene: A possible role in stroke
184. Application of real-time polymerase chain reaction to quantitate induced expression of interleukin-1beta mRNA in ischemic brain tolerance
185. Detection of tumor necrosis factor-alpha mRNA induction in ischemic brain tolerance by means of real-time polymerase chain reaction
186. Identification and molecular characterization of rat CXCR3: Discovery of increased expression and interferon-inducible protein-10 binding are increased in focal stroke
187. Analysis of risk factors for stroke in a cohort of men born in 1913
188. Transient forebrain ischemia induces an immediate-early gene encoding the mitogen-activated protein kinase phosphatase 3CH134 in the adult rat brain
189. Altered expression levels of SEF-2 and p112 in the rat hippocampus after transient cerebral ischemia: Identification by mRNA differential display
190. Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala
191. Differential production of MCP-1 and cytokine-induced neutrophil chemoattractant in the ischemic brain after transient focal ischemia in rats
192. Post-occlusion treatment with BDNF reduces infarct size in a model of permanent occlusion of the middle cerebral artery in rat
193. Infarct tolerance induced by intra-cerebral infusion of recombinant brain-derived neurotrophic factor
194. Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury
195. Attenuation of temporary focal cerebral ischemic injury in the mouse following transfection with interleukin-1 receptor antagonist
196. Ischemic preconditioning: Present position and future directions
197. Gene therapy with HSP 72 is neuroprotective in rat models of stroke and epilepsy
198. The neuroprotective potential of heat shock protein 70 (HSP 70)
199. Effect of JTP-2942, a novel thyrotropin-releasing hormone analog, on motor deficits after chronic focal cerebral ischemia in rats
200. Biomedical discovery with DNA arrays
201. A new rat model of thrombotic focal cerebral ischemia