Response of neurons to an irreversible inhibition of endoplasmic reticulum Ca2+-atpase: Relationship between global protein synthesis and expression and translation of individual genes

Biochemical Journal

Volumn 356, Issue 3, 2001, Pages 805-812

  Mengesdorf, T ^a   Althausen, S ^a   Oberndorfer, I ^a   Paschen, W ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

GADD 153; GRP78; Heat shock protein 70; Neuronal cell culture; Unfolded protein response

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); HEAT SHOCK PROTEIN 70; MESSENGER RNA; PROTEIN; PROTEIN P67; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM HOMEOSTASIS; CELL CULTURE; CELL DAMAGE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; EXPERIMENTAL MODEL; GENE CONTROL; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SYNTHESIS; RAT; RNA TRANSLATION; STRESS;

ANIMALS; BASE SEQUENCE; CALCIUM-TRANSPORTING ATPASES; CELLS, CULTURED; DNA PRIMERS; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-2; NEURONS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEINS; RATS; RNA, MESSENGER; THAPSIGARGIN;

ANIMALIA;

EID: 0035875397     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3560805     Document Type: Article

References (44)

1. Release and sequestration of calcium by ryanodine-sensitive stores in hippocampal neurons
2. Neuronal calcium signaling
3. Perturbation of cellular calcium blocks exit of secretory proteins from rough endoplasmic reticulum
4. Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol
5. Calcium is required for folding of newly made subunits of the asialoglycoprotein receptor within the endoplasmic reticulum
6. The ER-overload response: Activation of NF-κB
7. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
8. Disturbances of the functioning of endoplasmic reticulum: A key mechanism underlying neuronal cell injury?
9. Calcium signaling in the ER: Its role in neuronal plasticity and neurodegenerative disorders
10. 2+ ATPases
11. A eukaryotic translation initiation factor 2-associated 67 kDa glycoprotein partially reverses protein synthesis inhibition by activated double-stranded RNA-dependent protein kinase in intact cells
12. Depletion of neuronal endoplasmic reticulum calcium stores by thapsigargin: Effect on protein synthesis
13. Protein measurement with the Folin phenol reagent
14. 2+ release from sarcoplasmic reticulum by activating the ryanodine receptor
15. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
16. Temporal analysis of changes in neuronal c-fos mRNA levels induced by depletion of endoplasmic reticulum calcium stores: Effect of clamping cytoplasmic calcium activity at resting levels
17. Single-step method of RNA isolation by acidic guanidinium thiocyanate-phenol-chloroform extraction
18. Calcium mobilization by ryanodine promotes the phosphorylation of initiation factor 2α subunit and inhibits protein synthesis in cultured neurons
19. Calcium dependent regulation of protein synthesis in intact mammalian cells
20. Accommodation of protein synthesis to chronic deprivation of intracellular sequestered calcium
21. Phosphorylation of the eukaryotic initiation factor (elF) 2α and inhibition of elF-2B in GH3 pituitary cells by perturbants of early protein processing that induce grp78
22. Inhibition of protein synthesis and early protein processing by thapsigargin in cultured cells
23. 2+ and ionophore A23187 on protein synthesis in intact rabbit reticulocytes
24. Activation of MYD116 (gadd34) expression following transient forebrain ischemia of rat: Implications for a role or disturbances of endoplasmic reticulum calcium homeostasis
25. Recovery of neuronal protein synthesis after irreversible inhibition of the endoplasmic reticulum calcium pump
26. Activation of the double-stranded RNA-regulated protein kinase by depletion of endoplasmic reticulum calcium stores
27. Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis
28. p67 transcription regulates translation in serum-starved and mitogen-activated KRC-7 cells
29. Expression and activity of p67 are induced during heat shock
30. Erp72 expression activated by transient cerebral ischemia or disturbance of endoplasmic reticulum calcium stores
31. Activation of gadd153 expression through transient cerebral ischemia: Evidence that ischemia causes endoplasmic reticulum dysfunction
32. Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells
33. Increased gadd153 messenger RNA levels is associated with apoptosis in human leukemic cells treated with etoposide
34. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
35. Bcl-2 inhibits death of central neural cells induced by multiple agents
36. 2+ fluxes
37. Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus
38. Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS against neurological insults in vitro and in vivo
39. Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2
40. 2+ increases and cell death
41. Pretreatment with inducers of ER molecular chaperones protects epithelial cells subjected to ATP depletion
42. 2-Deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: Evidence for the involvement of stress proteins
43. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: Suppression of oxidative stress and stabilization of calcium homeostasis
44. Presenilin-1 mutations downregulate the signalling pathway of the unfolded protein response