Glucocorticoids inhibit mitochondrial matrix acyl-CoA dehydrogenases and fatty acid β-oxidation

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 272, Issue 5 35-5, 1997, Pages

  Lettéron, Philippe ^a   Brahimi Bourouina, Nassima ^b   Robin, Marie Anne ^b   Moreau, Alain ^b   Feldmann, Gérard ^b   Pessayre, Dominique ^b  

^a BEAUJON HOSPITAL   (France)

^b NONE

Author keywords

Hepatic lipid secretion; Steatohepatitis; Steatosis

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; DEXAMETHASONE SODIUM PHOSPHATE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL LIVER LEVEL; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID OXIDATION; HEPATITIS; LIPID TRANSPORT; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEATOSIS;

EID: 0030956006     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.272.5.g1141     Document Type: Article

References (32)

1. Amendt, B. A., C. Greene, L. Sweetman, J. Clothery, V. Shih, A. Moon, L. Teel, and W. J. Rhead. Short-chain acyl-coenzyme A dehydrogenase deficiency. Clinical and biochemical studies in two patients. J. Clin. Invest. 79: 1303-1309, 1987.
2. Andresen, B. S., P. Bros, C. Vianey-Saban, P. Divry, M. T. Zabot, C. R. Roe, M. A. Nada, A. Byskov, T. A. Kruse, S. Neve, K. Kristiansen, I. Knudsen, M. J. Corydon, and N. Gregersen. Cloning and characterization of human very-long-chain acyl-CoA dehydrogenase cDNA, chromosomal assignment of the gene and identification in four patients of nine different mutations within the VLCAD gene. Hum. Mol. Genet. 5: 461-472, 1996.
3. Bellringer, M. E., K. Rahman, and R. Coleman. Sodium valproate inhibits movement of secretory vesicles in rat hepatocytes. Biochem. J. 249: 513-519, 1988.
4. Deschamps, D., V. de Beco, C. Fisch, B. Fromenty, A. Guillouzo, and D. Pessayre. Inhibition by perhexiline of oxidative phosphorylation and the β-oxidation of fatty acids: possible role in pseudoalcoholic liver lesions. Hepatology 19: 948-961, 1994.
5. Deschamps, D., C. Fisch, B. Fromenty, A. Berson, C. Degott, and D. Pessayre. Inhibition by salicylic acid of the activation and thus oxidation of long chain fatty acids. Possible role in the development of Reye's syndrome. J. Pharmacol. Exp. Ther. 259: 894-904, 1991.
6. Fréneaux, E., B. Fromenty, A. Berson, G. Labbe, C. Degott, P. Lettéron, D. Larrey, and D. Pessayre. Stereoselective and nonstereoselective effects of ibuprofen enantiomers on mitochondrial β-oxidation of fatty acids. J. Pharmacol. Exp. Ther. 255: 529-535, 1990.
7. Fréneaux, E., G. Labbe, P. Lettéron, T. Le Dinh, C. Degott, J. Genève, D. Larrey, and D. Pessayre. Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: possible role in microvesicular steatosis induced by this antibiotic. Hepatology 8: 1056-1062, 1988.
8. Fromenty, B., C. Fisch, A. Berson, P. Lettéron, D. Larrey, and D. Pessayre. Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II. J. Pharmacol. Exp. Ther. 255: 1377-1384, 1990.
9. Fromenty, B., C. Fisch, G. Labbe, C. Degott, D. Deschamps, A. Berson, P. Lettéron, and D. Pessayre. Amiodarone inhibits the mitochondrial β-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J. Pharmacol. Exp. Ther. 255: 1371-1376, 1990.
10. Fromenty, B., E. Fréneaux, G. Labbe, D. Deschamps, D. Larrey, P. Lettéron, and D. Pessayre. Tianeptine, a new tricyclic antidepressant metabolized by β-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice. Biochem. Pharmacol. 38: 3743-3751, 1989.
11. Fromenty, G., S. Grimbert, A. Mansouri, M. Beaugrand, S. Erlinger, and D. Pessayre. Hepatic mitochondrial DNA deletion in alcoholics: association with microvesicular steatosis. Gastroenterology 108: 193-200, 1995.
12. Fromenty, B., P. Lettéron, C. Fisch, A. Berson, D. Deschamps, and D. Pessayre. Evaluation of human blood lymphocytes as a model to study the effects of drugs on human mitochondria. Effects of low concentrations of amiodarone on fatty acid oxidation, ATP levels and cell survival. Biochem. Pharmacol. 46: 421-432, 1993.
13. Fromenty, B., and D. Pessayre. Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. Pharmacol. Ther. 67: 101-154, 1995.
14. Genève, J., B. Hayat-Bonan, G. Labbe, C. Degott, P. Lettéron, E. Fréneaux, T. Le Dinh, and D. Pessayre. Inhibition of mitochondrial β-oxidation of fatty acids by pirprofen. Role in microvesicular steatosis due to this nonsteroidal anti-inflammatory drug. J. Pharmacol. Exp. Ther. 242: 1133-1137, 1987.
15. Grimbert, S., C. Fisch, D. Deschamps, A. Berson, B. Fromenty, G. Feldmann, and D. Pessayre. Effects of female sex hormones on mitochondria: possible role in acute fatty liver of pregnancy. Am. J. Physiol. 268 (Gastrointest. Liver Physiol. 31): G107-G115, 1995.
16. Grimbert, S., B. Fromenty, C. Fisch, P. Lettéron, A. Berson, A. M. Durand-Schneider, G. Feldmann, and D. Pessayre. Decreased mitochondrial oxidation of fatty acids in pregnant mice: possible relevance to the development of acute fatty liver of pregnancy. Hepatology 17: 628-637, 1993.
17. Itoh, S., M. Igarashi, Y. Tsukada, and A. Ichinoe. Non-alcoholic fatty liver with alcoholic hyalin after long-term glucocorticoid therapy. Acta Hepato-Gastroenterol. 24: 415-418, 1977.
18. Izai, K., Y. Uchida, T. Orii, S. Yamamoto, and T. Hashimoto. Novel fatty acid β-oxidation enzymes in rat liver mitochondria. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase. J. Biol. Chem. 267: 1027-1033, 1992.
19. Kesterson, J. W., G. R. Granneman, and J. M. Machinist. The hepatotoxicity of valproic acid and its metabolites in rats. I. Toxicologic, biochemical, and histopathologic studies. Hepatology 4: 1143-1152, 1984.
20. Labbe, G., B. Fromenty, E. Fréneaux, V. Morzelle, P. Lettéron, A. Berson, and D. Pessayre. Effects of various tetracycline derivatives on in vitro and in vivo β-oxidation of fatty acids, egress of triglycerides from the liver, accumulation of hepatic triglycerides, and mortality in mice. Biochem. Pharmacol. 41: 638-641, 1991.
21. Le Dinh, T., E. Fréneaux, G. Labbe, P. Lettéron, C. Degott, J. Genève, A. Berson, D. Larrey, and D. Pessayre. Amineptine, a tricyclic antidepressant, inhibits the mitochondrial oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J. Pharmacol. Exp. Ther. 247: 745-750, 1988.
22. Lehman, T. C., D. E. Hale, A. Bhala, and C. Thorpe. An acyl-coenzyme A dehydrogenase assay utilizing the ferricenium ion. Anal. Biochem. 186: 280-284, 1990.
23. Lettéron, P., V. Duchatelle, A. Berson, B. Fromenty, C. Fisch, C. Degott, J. P. Benhamou, and D. Pessayre. Increased ethane exhalation, an in vivo index of lipid peroxidation, in ethanol abusers. Gut 34: 409-414, 1993.
24. Lettéron, P., B. Fromenty, B. Terris, C. Degott, and D. Pessayre. Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice. J. Hepatol. 24: 200-208, 1996.
25. Maddaiah, V. T. Ammonium inhibition of fatty acid oxidation in rat liver mitochondria. A possible cause of fatty liver in Reye's syndrome and urea cycle defects. Biochem. Biophys. Res. Commun. 127: 565-570, 1985.
26. Nada, M. A., W. J. Rhead, H. Sprecher, H. Schulz, and C. R. Roe. Evidence for intermediate channeling in mitochondrial β-oxidation. J. Biol. Chem. 270: 530-535, 1995.
27. Nagao, M., B. Parimoo, and K. Tanaka. Developmental, nutritional, and hormonal regulation of tissue specific expression of the genes encoding various acyl-CoA dehydrogenases and α-subunit of electron transfer flavoprotein in rat. J. Biol. Chem. 268: 24114-24124, 1993.
28. Schon, E. A., M. Hirano, and S. DiMauro. Mitochondrial encephalomyopathies: clinical and molecular analysis. J. Bioenerg. Biomembr. 26: 291-299, 1994.
29. Shan, B., E. Vazquez, and J. A. Lewis. Interferon selectively inhibits the expression of mitochondrial genes: a novel pathway for interferon-mediated responses. EMBO J. 9: 4307-4314, 1990.
30. Simpson, M. V., C. D. Chin, S. A. Keilbaugh, T. S. Lin, and W. H. Prusoff. Studies on the inhibition of mitochondrial DNA replication by 3′-azido-3′-deoxythymidine and other dideoxynucleoside analogs which inhibits HIV-1 replication. Biochem. Pharmacol. 38: 1033-1036, 1989.
31. Treem, W. R., C. A. Witzleben, D. A. Piccoli, C. A. Stanley, D. E. Hale, P. M. Coates, and J. B. Watkins. Medium-chain and long-chain acyl CoA dehydrogenase deficiency: clinical, pathologic and ultrastructural differentiation from Reye's syndrome. Hepatology 6: 1270-1278, 1996.
32. Wieland, P., and B. H. Lauterburg. Oxidation of mitochondrial proteins and DNA following administration of ethanol. Biochem. Biophys. Res. Commun. 213: 815-819, 1995.