Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity

Journal of Pathology

Volumn 179, Issue 4, 1996, Pages 432-435

  Goldin, R D ^a   Ratnayaka, I D ^a   Breach, C S ^a   Brown, I N ^a   Wickramasinghe, S N ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Acetaminophen; Dichloromethylene diphosphonate; Liver; Macrophage

Indexed keywords

ACETOMINOPHEN; CLODRONIC ACID; LIPOSOME; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG TOXICITY; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER TOXICITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETAMINOPHEN; ADOLESCENT; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; CLODRONIC ACID; CRICETINAE; DRUG CARRIERS; FEMALE; GUINEA PIGS; HUMANS; LIPOSOMES; LIVER DISEASES; MACROPHAGES; MICE; MICE, INBRED C57BL;

EID: 0029844037     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199608)179:4<432::AID-PATH609>3.0.CO;2-S     Document Type: Article

References (16)

1. Meredith TJ, Vale JA. Epidemiology of analgesic overdose in England and Wales. Hum Toxicol 1984; 3(Suppl): 61S-74S.
2. Nelson SD. Molecular mechanisms of hepatotoxicity caused by acetaminophen. Semin Liver Dis 1990; 10: 267-278.
3. 2+. J Biol Chem 1985; 260: 13035-13040.
4. Seeff L, Cuccherine BA, Zimmerman HJ, Adler E, Benjamin SB. Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure. Ann Intern Med 1986; 104: 399-404.
5. Goldin RD, Ratnayaka ID, Breach CS, Wickramasinghe SN. Acetaminophen and macrophage activation. Int Hepatol Commun 1995; 4: 16-18.
6. Van Rooijen N, Kors N, Ende M, Dijkstra CD. Depletion and repopulation of macrophages in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate (DMDP). Cell Tissue Res 1990; 260: 215-222.
7. Claassen E, Van Rooijen N. Preparation and characteristics of dichloromethylene diphosphonate-containing liposomes. J Microencapsulation 1986; 3: 109-114.
8. Wickramasinghe SN, Mawas F, Hasan R, Brown IN, Goldin RD. Macrophages are a major source of acetaldehyde in circulating acetaldehyde-albumin complexes formed after exposure of mice to ethenol. Alcohol Clin Exp Res 1994; 18: 1463-1467.
9. Goldin RD, Ratnayaka ID, Brown IN, Wickramasinghe SN. The effect of Kupffer cell elimination on ethanol-induced liver damage in mice. Int J Exp Pathol 1995; 76: 353-360.
10. Davis M, Williams R. Hepatic disorders. In: Davies DM, ed. A Textbook of Adverse Drug Reactions. 3rd edn. Oxford: Oxford University Press. 1985; 250-290.
11. Laskin DL. Nonparenchymal cells and hepatotoxicity. Semin Liver Dis 1990; 10: 293-304.
12. Wickramasinghe SN. Alcohol-induced liver disease. In: Billiar TR, Curran RD, eds Hepatocyte and Kupffer Cell Interactions. Boca Raton, FL: CRC Press, 1992; 97-117.
13. Wickramasinghe SN, Barden G, Levy L. The capacity of macrophages from different murine tissues to metabolise ethanol and generate an ethanol-dependent non-dialysable cytotoxic activity in vitro. Alcohol Alcohol 1987; 22: 31-39.
14. Wickramasinghe SN, Hasan R. Comparison of the generation of albumin-associated cytotoxic activity in supernatants from ethanol-containing cultures of human blood-monocyte-derived macrophages and of two human hepatoma cell lines. Alcohol Alcohol 1991; 26: 147-153.
15. Adachi Y, Bradford BU, Gao W, Bojes HK, Thurman RG. Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 1994; 20: 453-460.
16. Festing MFW, Eydmann T. Genetic variation in the response of mice to xenobiotics in vitro. 1. General methodology and response to some model compounds. Toxicol In Vitro 1987; 1: 115-125.