Role of macrophages and inflammatory mediators in chemically induced toxicity

Toxicology

Volumn 160, Issue 1-3, 2001, Pages 111-118

  Laskin, Debra L ^a   Laskin, Jeffrey D ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Inflammatory mediators; Macrophages; Toxicity

Indexed keywords

CYTOKINE; GROWTH FACTOR; HYDROLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE SYNTHASE; NITROGEN; OZONE; PARACETAMOL; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANTIBODY PRODUCTION; ARTICLE; HOST RESISTANCE; IMMUNE SYSTEM; LIVER TOXICITY; LUNG TOXICITY; MACROPHAGE; MEDIATOR RELEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; SECRETORY CELL; TARGET ORGAN; TISSUE INJURY; TOXICITY; TRANSGENIC ANIMAL;

ACETAMINOPHEN; ANIMALS; INFLAMMATION MEDIATORS; LIVER DISEASES; LUNG DISEASES; MACROPHAGE ACTIVATION; MACROPHAGES; OZONE;

ANIMALIA;

EID: 0035819887     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00437-6     Document Type: Article

References (58)

1. The cell biology of macrophage activation
2. Pathological implications of nitric oxide, superoxide and peroxynitrite formation
3. Cachectin: More than a tumor necrosis factor
4. Transgenic and knockout analysis of the role of TNF in immune regulation and disease pathogenesis
5. Role of peroxynitrite in ozone-induced lung injury
6. Mice lacking inducible nitric oxide synthase are protected from ozone induced lung injury
7. Decreased inducible nitric oxide synthase (NOSII) activity and protection from ozone-induced injury in mice lacking the p50 subunit of NF-kB
8. Role of phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB) in regulating nitric oxide production in the lung following ozone inhalation
9. IFN-gamma induced TNF-alpha is a prerequisite for in vitro production of nitric oxide generated in murine peritoneal macrophage by IFN-gamma
10. Free radical chemistry of nitric oxide. Looking at the dark side
11. Protective and pathologic roles of nitric oxide in tissue injury
12. 3) is associated with decreased tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) production
13. Role of tumor necrosis factor-α and nitric oxide in acetaminophen hepatotoxicity
14. Role of nitric oxide in hepatotoxicity
15. Role of nitric oxide in acetaminophen induced hepatotoxicity in the rat
16. Decreased hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase
17. Taurine protects rat bronchioles from acute ozone exposure: A freeze fracture and electron microscopic study
18. Aminoguanidine selectively inhibits inducible nitric oxide synthase
19. Nitric oxide: Pathological mechanisms
20. Molecular mechanisms of immunological activation of Type II pneumocytes by ozone
21. The role of tumor necrosis factor and interleukin-1 in the immunoinflammatory response
22. Cytotoxic mechanism of tumor necrosis factor-α
23. Nonparenchymal cells and hepatotoxicity
24. Sinusoidal lining cells and hepatotoxicity
25. Xenobiotic-induced inflammation and injury in the liver
26. Role of nitric oxide in chemical-induced toxicity
27. Mechanisms of chemical toxicity: The dark side of the immune system
28. Role of nonparenchymal cells and inflammatory macrophages in hepatotoxicity
29. Macrophages, inflammatory mediators and lung injury. Methods: A companion
30. Phagocytes
31. Macrophages and inflammatory mediators in tissue injury
32. Potential role of macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver
33. Activation of liver macrophages for killing of hepatocytes following acetaminophen treatment of rats
34. Potential role of macrophages in acetaminophen hepatotoxicity. II. Mechanism of Macrophage accumulation and activation
35. Pulmonary and hepatic effects of inhaled ozone in rats
36. Multifunctional role of nitric oxide in inflammation
37. Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen
38. Hepatic nitric oxide production following acute endotoxemia in rats is mediated by increased inducible nitric oxide synthase gene expression
39. Increased nitric oxide synthase in the lung after ozone inhalation is associated with activation of NF-(kappa)B
40. A single exogenous stimulus activates rat macrophages for nitric oxide production and cytotoxicity
41. Macrophage and interleukin-1 induced nitric oxide production and cytostasis in hamster tumor cells
42. Role of CYP2E1 in the hepatotoxicity of acetaminophen
43. Health effects of tropospheric ozone: Review of recent research findings and their implications to ambient air quality standards
44. Transcriptional regulation of the genes encoding nitric oxide synthase
45. Secretory products of macrophages
46. Nitric oxide as a secretory product of mammalian cells
47. Role of nitric oxide synthesis in macrophage animicrobial activity
48. Enhanced production of nitric oxide by rat alveolar macrophages following inhalation of a pulmonary irritant is associated with increased expression of nitric oxide synthase
49. Enhanced production of interleukin-1, tumor necrosis factor-α and fibronectin by rat lung phagocytes following inhalation of a pulmonary irritant
50. Inhibition of macrophages with gadolinum chloride abrogates ozone-induced pulmonary injury and inflammatory mediator production
51. Inhibition of ozone-induced nitric oxide synthase expression in the lung by endotoxin
52. Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide
53. Peroxynitrite oxidation of sulfhydryls. The cytoxic potential of superoxide and nitric oxide
54. Role of cytokines in macrophage activation
55. Taurine protects rat bronchioles from acute ozone-induced lung inflammation and hyperplasia
56. Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
57. The NF-κB/Rel and IκB gene families: Mediators of immune response and inflammation
58. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide