CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of γ-glutamylcysteine synthetase

Journal of Biological Chemistry

Volumn 275, Issue 20, 2000, Pages 15563-15571

  Marí, Montserrat ^a   Cederbaum, Arthur I ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; DIMETHYLNITROSAMINE DEMETHYLASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HYDROGEN PEROXIDE;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME INDUCTION; GENE OVEREXPRESSION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

BUTHIONINE SULFOXIMINE; CARCINOMA, HEPATOCELLULAR; CYTOCHROME P-450 CYP2E1; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HUMANS; KINETICS; LIVER NEOPLASMS; RECOMBINANT PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED;

EUKARYOTA;

EID: 0034685775     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M907022199     Document Type: Article

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