Endocannabinoids and cannabinoid receptor genetics

Progress in Neurobiology

Volumn 66, Issue 5, 2002, Pages 307-344

  Onaivi, Emmanuel S ^a,b   Leonard, Claire M ^a   Ishiguro, Hiroki ^b   Zhang, Ping Wu ^b   Lin, Zhicheng ^b   Akinshola, Babatunde E ^c   Uhl, George R ^b  

^a WILLIAM PATERSON UNIVERSITY   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID DERIVATIVE; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CANNABIS; COMPLEMENTARY DNA; DEXANABINOL; FATTY ACID AMIDASE; G PROTEIN COUPLED RECEPTOR; HYDROLASE; ION CHANNEL; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; RIMONABANT;

ALCOHOL ABUSE; APPETITE; BIOAVAILABILITY; CHROMOSOME MAP; COGNITION; DNA POLYMORPHISM; DRUG ABUSE; DRUG DEPENDENCE; DRUG EFFECT; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; GENE STRUCTURE; GENETIC CODE; GENETIC VARIABILITY; GENOMICS; HUMAN; IN VITRO STUDY; INVERTEBRATE; KNOCKOUT MOUSE; MEDICAL RESEARCH; MENTAL DISEASE; MOLECULAR GENETICS; NEUROBIOLOGY; NEUROCHEMISTRY; NEUROMODULATION; NEUROPSYCHIATRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; VERTEBRATE;

AMINO ACID SEQUENCE; ANIMALS; BRAIN CHEMISTRY; CANNABINOIDS; ENDOCANNABINOIDS; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0036092316     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(02)00007-2     Document Type: Review

References (229)

1. Isolation and expression of a CB1 cannabinoid receptor gene. Comparison of binding properties with those of native CB1 receptors in mouse brain and N18TG2 neuroblastoma cells
2. Cannabinoid precipitated withdrawal: Induction by the antagonist SR141716A
3. The effects of delta-9-tetrahydrocannabinol on action potentials in the mollusk Aplysia
4. In vitro and in vivo action of cannabinoids
5. Anandamide inhibition of recombinant AMPA receptor subunits in Xenopus oocytes is increased by forskolin and 8-bromo-cyclic AMP
6. Straight-chain alcohols exhibit a cutoff in potency for the inhibition of recombinant glutamate receptor subunits
7. Selective inhibition of sucrose and ethanol intake by SR141716, an antagonist of central cannabinoid (CB1) receptors
8. 9-THC-induced central nervous effects in the mouse
9. Chronic ethanol increases the cannabinoid receptor agonist anandamide and its precursor N-arachidonoylphosphatidylethanolamine in SK-N-SH cells
10. Stimulation of cannabinoid receptor agonist 2-arachidonylglycerol by chronic ethanol and its modulation by specific neuromodulators in cerebellar granule neurons
11. The ontogeny of cannabinoid receptors in the brain of postnatal and aging rats
12. Cannabinoid receptors and the regulation of immune response
13. Occurrence and metabolism of anandamide and related acyl-ethanolamides in ovaries of the sea urchin Paracentrotus lividus
14. Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells: Implication for cell proliferation and differentiation
15. Oleamide: An endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules
16. Enhanced long-term potentiation in mice lacking cannabinoid CB1 receptors
17. Cannabinoid receptor expression in human leucocytes
18. Comparison of the effects of 9-tetrahydrocannabinol, 11-hydroxy-9-tetrahydrocannabinol, and ethanol on the electrophysiological activity of the giant axon of the squid
19. Construction of a 3D model of the cannabinoids CB1 receptor: Determination of the helix ends and helix orientation
20. Evidence for a new G protein-coupled cannabinoid receptor in mouse brain
21. Chocolate: Food or drug?
22. Development of a CB2 knockout mouse
23. Expression of the CB1 and Cb2 receptor messenger RNAs during embryonic development in the rat
24. Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor
25. HindIII identifies a two allele DNA polymorphism of the human cannabinoid receptor gene (CNR)
26. Dual intracellular signaling pathways mediated by the human cannabinoid CB1 receptor
27. Control of pain initiation by endogenous cannabinoids
28. Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees
29. The capsaicin receptor: A heat-activated ion channel in the pain pathway
30. Impaired nociception and pain sensation in mice lacking the capsaicin receptor
31. Cloning and sequencing of a cDNA encoding the mouse brain-type cannabinoid receptor protein
32. Neurobehavioral effects of anandamide and cannabinoid receptor gene expression in mice
33. Behavioral effects of cannabinoid agents in animals
34. Involvement of central cannabinoid (CB1) in the establishment of place conditioning in rats
35. Cannabis and endogenous cannabinoid systems
36. Excitatory amino acid receptors and synaptic plasticity
37. Reduction of voluntary ethanol intake in ethanol-preferring sP rats by the cannabinoid antagonist SR141716
38. Cannabinoid receptor gene (CNR1): Association with IV drug use
39. Cannabinoid inhibition of adenylate cyclase-mediated signal transduction and interleukin 2 (IL-2) expression in the murine T-cell line, EL4.IL-2
40. SR141716A induces in rats a behavioral pattern opposite to that of CB1 receptor agonist
41. Cannabinoid receptor proteins are increased in Jurkat human-T cell line after mitogen activation
42. Cannabinoid ligand-receptor signaling in the mouse uterus
43. Identification of a polymorphic triplet marker for the brain cannabinoid receptor gene: Use in linkage and association studies of schizophrenia
44. Finding of the endocannabinoid signaling system in Hydra, a very primitive organism: Possible role in the feeding response
45. Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor antagonist
46. Determination and characterization of cannabinoid receptor in rat brain
47. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
48. Brain cannabinoids in chocolate
49. Formation and inactivation of endogenous cannabinoid anandamide in central neurons
50. Interactions between synthetic vanilloids and the endogenous cannabinoid system
51. Cannabimimetic fatty acid derivatives: The anandamide family and other endocannabinoids
52. Endocannabinoids: New targets for drug development
53. Levels, metabolism, and pharmacological activity of anandamide in CB1 cannabinoid receptor knockout mice: Evidence for non-CB1, non-CB2 receptor-mediated actions of anandamide in mouse brain
54. Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
55. Evidence for non-CB1, non-CB2 anandamide receptors in mouse brain
56. Model systems for the study of seven-transmembrane-segment receptors
57. Fatty acid amide hydrolase expression in rat choroids plexus: Possible role in regulation of the sleep-inducing action of oleamide
58. An invertebrate G protein-coupled receptor is a chimeric cannabinoid/melanocortin receptor
59. The neurobiology and evolution of cannabinoid signaling
60. Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide
61. AP-1 activity is negatively regulated by cannabinol through inhibition of its protein components, C-Fos and C-Jun
62. Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones
63. The endogenous cannabinoid system and brain development
64. 2 receptor-like immunoreactivity in the embryonic chick brain
65. Effects of SR141716A on ethanol and sucrose self-administration
66. Actions of hallucinogens on ants (Formica pratensis). Part III. Social behavior under the influence of LSD and tetrahydrocannabinol
67. Are cannabinoid receptor knockout mice animal models of schizophrenia
68. A frequent polymorphism in the coding exon of the human cannabinoid receptor (CNR1) gene
69. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
70. The motivation for beer in rats: Effects of ritanserin, naloxone, and SR141716
71. Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor antagonist
72. Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current
73. Molecular cloning of a human cannabinoid receptor which is also expressed in the testis
74. CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum
75. Molecular characterization of human and mouse fatty acid amide hydrolase
76. Nuclear lipid signaling: Novel role of eicosanoids
77. The endocannabinoid system: A physiological perspective on its role in psychomotor control
78. Modulation of neurotransmission by cannabinoids in the basal ganglia
79. The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt
80. Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals
81. Cloning and pharmacological characterization of the rat CB2 cannabinoid receptor
82. Do endogenous cannabinoids contribute to HIV-mediated immune failure
83. Ceramide: A new second messenger of cannabinoid action
84. Role of cyclic AMP-dependent protein kinase in cannabinoid receptor modulation of potassium "a-current" in cultured rat hippocampal neurons
85. Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission
86. Cannabinoid and kappa opioid receptors reduce potassium K current via activation of G(s) proteins in cultured hippocampal neurons
87. 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
88. Investigation of genetic risk factors associated with alcoholism
89. Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes
90. Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiography study
91. Modulation of CREB abd NF-kB signal transduction by cannabinol in activated thymocytes
92. Persisting consequences of drug intake: Towards a memory of addiction
93. Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol
94. In-vitro inactivation of brain protein kinase C by the cannabinoids
95. Effects of the cannabinoids on physical properties of brain membranes and phospholipid vesicles: Fluorescence studies
96. Accumulation of N-arachidonoyethanolamine (anandamide) into cerebral granule cells occurs via facilitated diffusion
97. Coupling of the expressed cannabinoid CB1 and CB2 receptors to phospholipase C and G protein-coupled inwardly rectifying K+ channels
98. Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6q14-q15
99. Direct actions of cannabinoids on synaptic transmission in the nucleus accumbens: A comparison with opioids
100. Health aspects of cannabis
101. Cellular signal transduction by anandamide and 2-arachidonoylglycerol
102. Nonclassical cannabinoid analgetics inhibit adenylate cyclase: Development of a cannabinoid receptor model
103. A cannabinoid receptor in Drosophila is pharmacologically unique
104. Medical uses of marijuana?
105. Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability
106. Association between the cannabinoid receptor gene (CNR1) and the P300 event-related potential
107. Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal cells of rat hippocampal slices
108. Exchange of three amino acids in the cannabinoid CB1 receptor (CNR1) of an epilepsy patient
109. Rat microglial cell express the peripheral-type cannabinoid receptor (CB2) which is negatively coupled to adenylyl cyclase
110. Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta
111. 9-THC in rats
112. Endocannabinoids as cardiovascular modulators
113. Biosynthesis and turnover of anandamide and other N-acylethanolamines in peritoneal macrophages
114. Introns as mobile genetic elements
115. Alcohol consumption by C57BL/6 Balb/c and DBA/2 mice in a limited access paradigm
116. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
117. Effects of some components of cannabis sativa on the regenerating planarian worm dugesia tigrina
118. Conditioned place preference induced by delta 9-tetrahydrocannabinol: Comparison with cocaine, morphine, and food reward
119. No association between (AAT)n repeats in the cannabinoid receptor gene (CNR1) and heroin abuse in a Chinese population
120. High ethanol sensitivity of recombinant AMPA-type glutamate receptors expressed in mammalian cells
121. Expression of CB2 cannabinoid receptor mRNA in adult rat retina
122. Anandamide hydrolysis by human cells in culture and brain
123. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
124. Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor
125. Distribution of cannabinoid receptor messenger RNA in the human brain: An in situ hybridization histochemistry with oligonucleotides
126. 2H-NMR
127. Delta-9-tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place avoidance
128. Discovery and characterization of endogenous cannabinoids
129. Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human
130. Follow-up study on a susceptibility locus for schizophrenia on chromosome 6q
131. Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB receptor knockout mice
132. Structure of a cannabinoid receptor and functional expression of the cloned cDNA
133. Localization of cannabinoid mRNA in rat brain
134. Molecular aspects of cannabinoid receptors
135. Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a Xenopus oocyte expression system
136. Action of delta 9-tetrahydrocannabinol on cell division and macromolecular synthesis in division-synchronized protozoa
137. Aversive effects of the synthetic cannabinoid receptor agonist CP 55,940 in rats
138. Developmental expression of cannabinoid receptor mRNA
139. Cannabinoid receptors are absent in insects
140. Recent advances in cannabinoid research
141. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
142. Endocannabinoids
143. Cannabinoid receptors differentially modulate potassium A and D currents in hippocampal neurons in culture
144. Molecular characterization of a peripheral cannabinoid receptor
145. Molecular phylogenetics and origins of placental mammals
146. Blockade of 45Ca2+ influx through the N methyl-D-aspartate receptor ion channel by the non-psychoactive cannabinoid HU-211
147. Occurrence of a novel cannabimimetic molecule 2-sciadonoylglycerol (2-eicosa-5′, 11′, 14′-trienoylglycerol) in the umbrella pine Sciadopitys verticillata seeds
148. CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats
149. 2+ signals in cerebellar granule neurons in culture
150. Structures of dopamine receptors
151. Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals
152. Pharmacological characterization of cannabinoids in the elevated plus maze
153. Neurobehavioral effects of delta-9-THC and cannabinoid receptor gene expression in mice
154. Cannabinoid receptor genes
155. Murine Cannabinoid receptor genetics
156. 2+ channels in a neuronal expression system
157. Ligand-receptor signaling with endocannabinoids in preimplatation embryo development and implantation
158. Pharmacology of cannabinoid CB1 and CB2 receptors
159. O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties
160. Expression of a cannabinoid receptor in baculovirus-infected insect cells
161. Physical and genetic localization of the bovine cannabinoid receptor (CNR1) gene to bovine chromosome 9
162. Structural determinants for recognition and translocation by the anandamide transporter
163. The endocannabinoid system as a target for therapeutic drugs
164. Blockade of cannabinoid (CB1) receptors by SR141716 selectively antagonizes drug-induced reinstatement of exploratory behavior in gerbils
165. Susceptibility of Naegleria fowleri to delta-9-tetrahydrocannabinol
166. Enhancement of memory in cannabinoid CB1 receptor knockout mice
167. Cannabinoid-induced alterations in brain disposition of drugs of abuse
168. Characterization of two cloned CB1 cannabinoid receptor isoforms
169. Presence of cannabinoid binding sites in the brain from early postnatal ages
170. Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers
171. Ultrastructural localization of the CB1 cannabinoid receptor in μ-opioid receptor patches of the rat caudate putamen nucleus
172. Comparative biology of the endocannabinoid system. Possible role in the immune response
173. The CB1 cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan
174. Endogenous cannabinoids as an aversive or counter-rewarding system in the rat
175. Cannabinoid receptors CB1 and CB2: A characterization of expression and adenylate cyclase modulation within the immune system
176. The N-acylation-phosphodiesterase pathway and cell signaling
177. Cannabinoids reduce fertility of sea urchin sperm
178. Anandamide (arachidonylethanolamide), a brain cannabinoid receptor agonist, reduces sperm fertilizing capacity in sea urchins by inhibiting the acrosome reaction
179. Cannabinoids decrease the K(+) M-current in hippocampal CA1 neurons
180. Bioactive long chain N-acylethanolamines in five species of edible bivalve mollusks. Possible implications for mollusk physiology and sea food industry
181. Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures
182. An amino terminal variant of the central cannabinoid receptor resulting from alternative splicing
183. Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor
184. Cannabinoid receptor interactions with the antagonists SR 141716A and SR 144528
185. Grenadadiene and grenadamide, cyclopropyl-containing fatty acid metabolites from the marine cyanobacterium Lyngbya majuscula
186. The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons
187. Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase
188. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
189. CB1 cannabinoid receptor expression in brain regions associated with zebra finch song control
190. Zebra finch CB1 cannabinoid receptor: Pharmacology and in vivo and in vitro effects of activation
191. Behavioral, pharmacological, and molecular characterization of an amphibian cannabinoid receptor
192. A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2
193. Localization of cannabinoid CB1 receptors in the human anterior eye and retina
194. Cannabinoid CB1 receptors and ligands in vertebrate retina: Localization and function of an endogenous signaling system
195. Cannabinoid receptors are coupled to nitric oxide release in invertebrate immunocytes, microglia, and human monocytes
196. Identification and characterization of the leech CNS cannabinoid receptor: Coupling to the nitric oxide release
197. Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout mice
198. Structure and function of G-coupled receptors
199. Interaction of dexanabinol (HU-211), a novel NMDA receptor antagonist, with the dopaminergic system
200. The mouse cannabinoid receptor gene is located in proximal chromosome 4
201. 2-Arachidonoylglycerol and cannabinoid receptors
202. 2-Arachidonoylglycerol: A possible endogenous cannabinoid ligand in brain
203. Are cannabinoids endogenous ligands for the VR1 capsaicin receptor
204. Inhibition of long-term potentiation in rat hippocampal slices by anandamide and WIN55212-2: Reversal by SR141716 A, a selective antagonist of CB1 cannabinoid receptors
205. Alcohol and alcohol dehydrogenase genotypes and alcoholism in Chinese men
206. Changes in neurotransmitter release at a neuromuscular junction of the lobster caused by cannabinoids
207. Measuring reward with the conditioned place preference paradigm: A comprehensive review of drug effects, recent progress and new issues
208. An acid amidase hydrolyzing anandamide and other N-acylethanolamines
209. 9-tetrahydrocannabinol in mice
210. The genes encoding the peripheral cannabinoid receptor and a-L-fucosidase are located near a newly identified common virus integration site, Evi11
211. Reduction of stress-induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors
212. D-9-Tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: Reduction in morphin withdrawal syndrome without change in rewarding effect
213. Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension
214. Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitro
215. Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation
216. Synergistic interactions of endogenous opioids and cannabinoid systems
217. Cannabinoid receptor binding and messenger RNA expression in human brain: An in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains
218. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
219. 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans
220. Molecular cloning of two cannabinoid type1-like receptor genes from the puffer fish Fugu rubripes
221. Role of cannabinoid receptor in the brain as it relates to drug reward
222. Immunocytochemical localization of cannabinoid CB1 receptor and fatty acid amide hydrolase in rat retina
223. Cannabinoid receptors on goldfish retinal bipolar cells: Electron-microscope immunocytochemistry and whole-cell recordings
224. Role of nuclear factor of activated T-cells and activator protein-1 in the inhibition of interleukin-2 gene transcription by cannabinol in EL4 T-cells
225. 9-THC on expression of cannabinoid (CB1) mRNA in different rat brain regions
226. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
227. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide