An invertebrate G-protein coupled receptor is a chimeric cannabinoid/melanocortin receptor

Brain Research

Volumn 780, Issue 1, 1998, Pages 170-173

  Elphick, Maurice R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Adrenocorticotropic hormone receptor; Cannabinoid receptor; G protein coupled receptor; Leech; Melanocortin receptor

Indexed keywords

CANNABINOID; GUANINE NUCLEOTIDE BINDING PROTEIN; HORMONE RECEPTOR; MELANOCORTIN RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; CENTRAL NERVOUS SYSTEM; CHIMERA; DNA CONTENT; DRUG RECEPTOR BINDING; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; RECEPTOR UPREGULATION;

AMINO ACID SEQUENCE; ANIMALS; CANNABINOIDS; CATTLE; GTP-BINDING PROTEINS; HUMANS; LEECHES; MOLECULAR SEQUENCE DATA; RECEPTORS, CANNABINOID; RECEPTORS, CELL SURFACE; RECEPTORS, CORTICOTROPIN; RECEPTORS, DRUG; RECEPTORS, MELANOCORTIN; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0032484523     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01297-3     Document Type: Article

References (11)

1. Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D.J. Basic local alignment search tool. J. Mol. Biol. 215:1990;403-410.
2. Cone R.D., Lu D.S., Koppula S., Vage D.I., Klungland H., Boston B., Chen W.B., Orth D.N., Pouton C., Kesterson R.A. The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog. Hormone Res. 51:1996;287-318.
3. Devane W.A., Dysarz F.A., Johnson M.R., Melvin L.S., Howlett A.C. Determination and characterization of a cannabinoid receptor in rat brain. Mol. Pharmacol. 34:1988;605-613.
4. Devane W.A., Hanus L., Breuer A., Pertwee R.G., Stevenson L.A., Griffin G., Gibson D., Mandelbaum A., Etinger A., Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 258:1992;1946-1949.
5. Kolakowski L.F. GCRDb: A G-protein-coupled receptor database (http://receptor.mgh.harvard.edu/gcrdb.entry.html). Receptors and Channels. 2:1994;1-7.
6. Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 346:1990;561-564.
7. Mountjoy K.G., Robbins L.S., Mortrud M.T., Cone R.D. The cloning of a family of genes that encode the melanocortin receptors. Science. 257:1992;1248-1251.
8. Munro S., Thomas K.L., Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature. 365:1993;61-65.
9. R.G. Pertwee (Ed), Cannabinoid Receptors, Academic Press, London (1995) 264 pp.
10. Song Z-H., Bonner T.I. A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2. Mol. Pharmacol. 49:1996;891-896.
11. Stefano G.B., Salzet B., Salzet M. Identification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide release. Brain Res. 753:1997;219-224.