Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human

British Journal of Pharmacology

Volumn 129, Issue 8, 2000, Pages 1707-1715

  Martin, R S ^a   Luong, L A ^a   Welsh, N J ^b   Eglen, R M ^a   Martin, G R ^a   MacLennan, S J ^a  

^a Center for Biological Research   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cannabinoid receptor; Neurogenic contraction; Receptor orthologue; Urinary bladder; WIN 55212 2

Indexed keywords

2 METHYL 3 (1 NAPHTHOYL) 1 PROPYLINDOLE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ANANDAMIDE; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; DEXANABINOL; RIMONABANT;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; CHEMICAL PARAMETERS; CONTROLLED STUDY; DOG; DRUG POTENCY; EVOKED MUSCLE RESPONSE; FEMALE; HUMAN; HUMAN TISSUE; MALE; MAMMAL; MONKEY; MOUSE; NONHUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; RAT; SWINE;

EID: 0034002184     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703229     Document Type: Article

References (22)

1. ANDERSON, K.E. (1993). Pharmacology of the lower urinary tract smooth muscles and penile erectile tissues. Pharmacol. Rev., 45, 253-308.
2. ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother., 14, 48-58.
3. BREIVOGEL, C.S., SIM, L.J. & CHILDERS, S.R. (1997). Regional differences in cannabinoid receptor/G-protein coupling in rat brain. J. Pharmacol. Exp. Ther., 282, 1632-1642.
4. BURNSTOCK, G., DUMSDAY, B. & SMYTHE, A. (1972). Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. Br. J. Pharmacol., 44, 451-461.
5. GABELLA, G. (1990). Intramural neurons in the urinary bladder of the guinea-pig. Cell Tissue Res., 261, 231-237.
6. GILPIN, C.J., DIXON, J.S., GILPIN, S.A. & GOSLING, G.A. (1983). The fine structure of autonomie neurons in the wall of the human urinary bladder. J. Anatomy, 137, 705-713.
7. 2-like cannabinoid receptors on peripheral nerve terminals. Eur. J. Pharmacol., 339, 53-61.
8. 35S]GTPγS binding in the mouse brain. Eur. J. Pharmacol., 321, R1-R3.
9. LICHTMAN, A.H., COOK, S.A. & MARTIN, B.R. (1995). Investigation of brain sites mediating cannabinoid-induced antinociception in rats: evidence supporting periaqueductal gray involvement. J. Pharmacol. Exp. Ther., 276, 585-593.
10. LYNN, A.B. & HERKENHAM, M. (1994). Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: Implications for receptor-mediated immune modulation by cannabinoids. J. Pharmacol. Exp. Ther., 268, 1612-1623.
11. MARTYN, C.N., ILLIS, L.S. & THOM, J. (1995). Nabilone in the treatment of multiple sclerosis. Lancet, 345, 579.
12. PACHECO, M., CHILDERS, S.R., ARNOLD, R., CASIANO, F. & WARD, S.J. (1991). Aminoalkylindoles: actions on specific G-protein-linked receptors. J. Pharmacol. Exp. Ther., 257, 170-183.
13. PALEA, S., ARTIBANI, W., OSTARDO, E., TRIST, D.G. & PIETRA, C. (1993). Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis. J. Urol., 150, 2007-2012.
14. 1 receptors in mouse urinary bladder. Br. J. Pharmacol., 118, 2053-2058.
15. PERTWEE, R.G., STEVENSON, L.A., EERICK, D.B., MECHOULAM, R. & CORBETT, A.D. (1992). Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas deferens and myenteric plexus preparation of guinea-pig small intestine. Br. J. Pharmacol., 105, 980-984.
16. 2 cannabinoid receptor. J. Pharmacol. Exp. Ther., 284, 644-650.
17. 1 cannabinoid isoforms. J. Pharmacol. Exp. Ther., 278, 871-878.
18. 2 cannabinoid receptors of L759633, L759656 and AM630. Br. J. Pharmacol., 126, 665-671.
19. 2): Identification of cannabinoid receptor subtype selective ligands. J. Pharmacol. Exp. Ther., 278, 989-999.
20. SIBLEY, G.N.A, (1984). A comparison of spontaneous and nerve-mediated activity in bladder muscle from man, pig and rabbit. J. Physiol., 354, 431-443.
21. 2-antagonism by clonidine and dimiprit in an adenylate cyclase assay. Agents Actions, 16, 222-226.
22. VANDERHORST, V.G., MOUTON, L.J., BLOK, B.F. & HOLSTEGE, G. (1996). Distinct cell groups in the lumbosacral cord of the cat project to different areas in the periaqueductal gray. J. Comp. Neurol., 376, 361-385.