Endocannabinoids as cardiovascular modulators

Chemistry and Physics of Lipids

Volumn 108, Issue 1-2, 2000, Pages 159-168

  Kunos, George ^a,b   Járai, Zoltán ^a   Bátkai, Sándor ^a   Goparaju, Sravan Kumar ^a   Ishac, Edward J N ^a   Liu, Jie ^a   Wang, Lei ^a   Wagner, Jens A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Cannabinoids; Cardiovascular effects; Marijuana

Indexed keywords

ANANDAMIDE; CANNABINOID; CANNABINOID RECEPTOR; CANNABIS; RECEPTOR SUBTYPE;

ADRENERGIC ACTIVITY; BLOOD PRESSURE REGULATION; BRADYCARDIA; HEART RATE VARIABILITY; HUMAN; HYPOTENSION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; VASODILATATION;

ARACHIDONIC ACIDS; CANNABINOIDS; CANNABIS; CARDIOVASCULAR SYSTEM; ENDOCANNABINOIDS; POLYUNSATURATED ALKAMIDES; VASODILATION;

CANNABIS; CANNABIS SATIVA;

EID: 0033667053     PISSN: 00093084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-3084(00)00194-8     Document Type: Review

References (78)

1. (R)-methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability
2. Marihuana
3. A cannabinoid with cardiovascular activity but no overt behavioral effects
4. Functional role of high affinity anandamide transport, as revealed by selective inhibition
5. Cardiovascular effects of prolonged delta-9-tetrahydro-cannabinol ingestion
6. Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes
7. Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells
8. 2+-induced relaxation of isolated arteries
9. Potentiation of anandamide hypotension by the transport inhibitor AM404
10. Effects of diethyl ether, halothane, ketamine and urethane on sympathetic activity in the rat
11. The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication
12. Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist
13. Production and physiological actions of anandamide in the vasculature of the rat kidney
14. Determination and characterization of a cannabinoid receptor in rat brain
15. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
16. Formation and inactivation of endogenous cannabinoid anandamide in central neurons
17. Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells
18. Biosynthesis and inactivation of endocannabinoid 2-arachidonylglycerol in circulating and tumoral macrophages
19. + is an endothelium-derived hyperpolarizing factor in rat arteries
20. 2+-dependent release from rat brain of cannabinoid receptor binding activity
21. Endogenous cannabinoid receptor binding activity released from rat brain slices by depolarization
22. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned cannabinoid receptor and stimulates receptor mediated signal transduction
23. Morphine and anandamide stimulate intracellular calcium transients in human arterial endothelial cells: Coupling to nitric oxide release
24. Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists
25. Isolation, structure, and partial synthesis of an active constituent of hashish
26. Binding of the non-classical cannabinoid CP 55 940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors
27. 2+ channel current
28. Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors
29. Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)
30. Cannabinoid CB1 receptors fail to cause relaxation, but couple via G(i)/G(o) to the inhibition of adenylyl cyclase in carotid artery smooth muscle
31. Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cells
32. 9-THC and related compounds: Synthesis of selective ligands for the CB2 receptor
33. Identification of two related pentapeptides from the brain with potent opiate agonist activity
34. Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nerves
35. Cannabinoid-induced mesenteric vasodilation through an endothelial site of action distinct from CB1 and CB2 receptors
36. Cardiovascular effects of 2-arachidonoyl glycerol in anaesthetized mice
37. 9-THC (cannabis) on cardiac performance with or without beta blockade
38. Cardiovascular effects of endocannabinoids - The plot thickens
39. Cannabinoid-induced hypotension and bradycardia in rats is mediated by CB1-like cannabinoid receptors
40. Cardiovascular effects of anandamide in anaesthetized and conscious normotensive and hypertensive rats
41. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
42. Functional CB1 cannabinoid receptors in vascular endothelial cells
43. Cannabinoid CB1 receptor-mediated inhibition of the neurogenic vasopressor response in the pithed rat
44. Molecular aspects of cannabinoid receptors
45. Structure of a cannabinoid receptor and functional expression of the cloned cDNA
46. The microcirculation during endotoxemia
47. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
48. Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid
49. 2+ in endothelial cells
50. Molecular characterization of a peripheral receptor for cannabinoids
51. Effect of the cannabinoid receptor agonist WIN 55212-2 on sympathetic cardiovascular regulation
52. Opiate receptor: Demonstration in nervous tissue
53. Pharmacology of cannabinoid receptor ligands
54. Effects of two endogenous fatty acid ethanolamides on mouse vasa deferentia
55. Endocannabinoids: A novel class of vasoactive substances
56. SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor
57. SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor
58. Cannabis, marijuana and cannabinoid toxicological manifestations in man and animals
59. Cannabinoid receptor interactions with the antagonists SR 141716A and SR 144528
60. Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands
61. The triple effect induced by delta 9-tetrahydrocannabinol on the rat blood pressure
62. Physiological and behavioural effects of the endogenous cannabinoid, arachidonylethanolamide (anandamide), in the rat
63. A second endogenous cannabinoid that modulates long-term potentiation
64. 2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
65. Detection of an endogenous cannabinoid molecule, 2-arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: Is 2-arachidonoylglycerol a possible vasomodulator?
66. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor
67. Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide
68. Mechanism of the hypotensive action of anandamide in anaesthetized rats
69. Platelet- and macrophage-derived cannabinoids are involved in endotoxin-induced hypotension
70. Cardiovascular effects of (-)-11-OH-delta-8-tetrahydrocannabinol-dimethylheptyl in rats
71. Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase
72. 9-trans-tetrahydrocannabinol
73. Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock
74. Mesenteric vasodilation mediated by endothelial anandamide receptors
75. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
76. Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery
77. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide