Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension

FASEB Journal

Volumn 12, Issue 11, 1998, Pages 1035-1044

  Varga, Károly ^a   Wagner, Jens A ^a   Bridgen, D Troy ^a   Kunos, George ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2 arachidonyl glyceride; Anandamide; CB1 cannabinoid receptors; Vasodilation

Indexed keywords

CANNABINOID; ENDOTOXIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GAS CHROMATOGRAPHY; HEMORRHAGIC HYPOTENSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MACROPHAGE; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; SYMPATHETIC TONE; TACHYCARDIA; THROMBOCYTE;

ANIMALS; ARACHIDONIC ACIDS; BLOOD PLATELETS; CANNABINOIDS; CELLS, CULTURED; GLYCERIDES; HYPOTENSION; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; NITRIC OXIDE; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0031823187     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J., and Mathison, J. C. (1990) GD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein Science 249, 1431-1433
2. Dentener, M. A., Bazi, V., Von Asmuth, E. J., Ceska, M., and Buurman, W. A. (1993) Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytcs and alveolar macrophages. J. Immunol. 150, 2885-2891
3. Sherry, B., and Cerami, A. (1988) Cachectin/tumor necrosis factor exerts endocrine, paracrine, and autocrine control of inflammatory responses. J. Cell Biol. 107, 1269-1277
4. Stone, R. (1994) Search for sepsis drugs goes on despite past failures. Science 264, 365-367
5. Natanson, C., Hoffman, W. D., Suffredini, A. F., Eichacker, P. Q., Danner, R. L. (1994) Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann. Int. Med. 120, 771-783
6. Devane, W. A., Hanus, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., and Mechoulam, R. (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949
7. Varga, K., Lake, K., Martin, B. R., and Kunos, G. (1995) Novel antagonist implicates the CB1 cannabinoid receptor in the hypotensive action of anandamide. Eur. J. Pharmacol. 278, 279-283
8. Lake, K. D., Compton, D. R., Varga, K., Martin, B. R., and Kunos, G. (1997) Cannabinoid-induced hypotension and bradycardia in rats is mediated by CB1 cannabinoid receptors. J Pharmacol. Exp. Ther. 281, 1030-1037
9. Stein, E. A., Fuller, S. A., Edgemond, W. S., and Campbell, W. B. (1996) Physiological and behavioural effects of the endogenous cannabinoid, arachidonylethanolamide (anandamide), in the rat. Br. J. Pharmacol. 119, 107-114
10. Calignano, A., La Rana, G., Beltramo, M., Makryannis, A., and Piomelli, D. (1997) Potentiation of anandamide hypotension by the transport inhibitor, AM404. Eur. J. Pharmacol. 337, R1-R2
11. Devane, W. A., and Axelrod, J. (1994) Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes. Proc. Natl. Acad. Sci. USA 91, 6698-6701
12. Di Marzo, V., Fontana, A., Cadas, H., Schinelli, S., Cimino, G., Schwartz, J.-C., and Piomelli, D. (1994) Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature (London) 372, 686-691
13. Cadas, H., Di Tomaso, E., and Piomelli, D. (1997) Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain. J. Neurosci. 17, 1226-1242
14. Di Marzo, V., De Petrocellis, L., Sepe, N., and Buono, A. (1996) Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells. Biochem. J. 316, 977 (1996)
15. Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kami risky, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., Pertweee, R. G., Griffin, G., Bayewitch, M., Barg, J., and Vogel, Z. (1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50, 83-90
16. Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., and Waku, K. (1995) 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem. Biophys. Res. Commun. 215, 89-97
17. Stella, N., Schweitzer, P., and Piomelli, D. (1997) A second endogenous cannabinoid that modulates long-term potentiation. Nature (London) 388, 773-778
18. Bisogno, T., Sepe, N., Melck, D., Maurelli, S., De Petrocellis, L., and Di Marzo, V. (1997) Biosynthesis, release, and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells. Biochem. J. 322, 671-677
19. Wagner, J. A., Varga, K., Ellis, E. F., Rzigalinski, B. A., Martin, B. A., and Kunos, G. (1997) Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock. Nature (London) 390, 518-521
20. Rinaldi-Carmona, M., Barth, F., Heaulme, M., Shire, D., Calandra, B., Congy, C., Martinez, S., Maruani, J., Meliat, G., and Caput, D. (1994) SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett. 350, 240-244
21. Böyum, A. (1968) Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Lab. Clin. Invest. 21 (Suppl. 97), 77-89
22. Deutsch, D. R., and Chin, S. A. (1993) Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist, Biochem. Pharmacol. 46, 791-796
23. Amrutesh, S. C., Falck, J. R., and Ellis, E. F. (1992) Brain synthesis and cerebrovascular action of epoxygenase metabolites of arachidonic acid. J Neurochem. 58, 503-510
24. Sravan Kumar, G., Ueda, N., Yamaguchi, H., and Yamamoto, S. (1998) Anandamide amidohydrolase catalyzing the hydrolysis of 2-arachidonoyl glycerol: another endogenous cannabinoid receptor ligand. FEBS Lett. 422, 69-75
25. Patrini, G., Sacerdote, P., Fuzio, D., Manfredi, B., and Parolaro, D. (1997) Regulation of immune functions in rat splenocytes after acute and chronic in vivo treatment with CP55, 940, a synthetic cannabinoid compound. J. Neuroimmunol. 80, 143-148
26. Schatz, A. R., Lee, M., Condie, R. B., Pulaski, J. T., and Kaminski, N. E. (1997) Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system. Toxicol. Appl. Pharmacol. 142, 278-287
27. Varga, K., Lake, K. D., Huangfu, D., Guyenet, P., and Kunos, G. (1996) Mechanism of the hypotensive action of anandamide in anesthetized rats. Hypertension 28, 682-688
28. Halling, J. L., Hamill, D. R., Lei, M. G., and Morrison, D. C. (1992) Identification and characterization of lipopolysaccharide-binding proteins on human peripheral blood cell populations. Infect. Immun. 60, 845-852
29. Ishac, E. J. N., Jiang, L., Lake, K. D., Varga, K., Abood, M. A., and Kunos, G. (1996) Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nerves. Br. J. Pharmacol. 118, 2023-2028
30. Malinowska, B., Godlewski, G., Bucher, B., and Schlicker, E. (1997) Cannabinoid CB1 receptor-mediated inhibition of the neurogenic vasopressor response in the pithed rat. Naunyn Schmiedeberg's Arch. Pharmacol. 356, 197-202
31. 9-THC-dilation of cerebral arterioles is blocked by indomethacin. Am. J. Physiol. 269, H1859-H1864
32. 2+ currents in cat cerebral arteriolar smooth muscle cells. FASEB J. 10, A302 (abstr.)
33. Randall, M. D., Alexander, S. P. H., Bennett, T., Boyd, E. A., Fry, J. R., Gardiner, S. M., Kemp, P. A., McCulloch, A. I., and Kendall, D. A. (1996) An endogenous cannabinoid as an endothelium- derived vasorelaxant. Biochem, Biophys. Res. Commun. 229, 114-120
34. Prescott, S. M., and Majerus, P. W. (1983) Characterization of 1, 2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate. J. Biol. Chem. 258, 764-769
35. Rinaldi-Carmona, M., Barth, F., Millan, J., Derocq, J.-M., Casellas, P., Congy, C., Oustric, D., Sarran, M., Bouaboula, M., Calandra, B., Portier, M., Shire, D., Breliere, J.-C., and Le Fur, G. (1998) SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor. J. Pharmacol, Exp. Ther. 284, 644-650
36. Peitzmann, A. B. (1995) Hemorrhagic shock. Curr. Probl. Surg. 32, 927-1002
37. McCuskey, R. S., Urbaschek, R., and Urbaschek, B. (1996) The microcirculation during endotoxemia. Cardiovasc. Res. 32, 752-763
38. Sun, X., Rozenfeld, R. A., Qu, X., Huang, W., Gonzalez-Crussi, F., and Hsueh, W. (1997) P-selectin-deficient mice are protected from PAF-induced shock, intestinal injury, and lethality. Am. J. Physiol. 273, G56-G61
39. Cummings, C. J., Sessler, C. N., Beall, L. D., Fisher, B. J., Best, A. M., and Fowler, A. A., III (1997) Soluble E-selectin levels in sepsis and critical illnesses. Am. J. Resp. Care Med. 156, 431-437
40. Hillard, C. J., Edgemond, W. S., Jarrahian, A., and Campbell, W. B. (1997) Accumulation of N-arachidonoylcthanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion. J. Neurochem. 69, 631-638
41. Beltramo, M., Stella, N., Calignano, A., Lin, S. Y., Makryannis, A., and Piomelli, D. (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277, 1094-1097
42. Bisogno, T., Maurelli, S., Melck, D., De Petrocellis, L., and Di Marzo, V. (1997) Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes. J. Biol. Chem. 272, 3315-3323
43. Di Marzo, V., Bisogno, T., Sugiura, T., Melck, D., De Petrocellis, L. (1998) The novel endogenous cannabinoid 2-arachidonylglycerol is inactivated by neuronal- and basophil-like cells; connections with anandamide. Biochem. J. 331, 15-19
44. Plane, F., Holland, M., Waldron, G. J., Garland, C. J., and Boyle, J. P. (1997) Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries. Br. J. Pharmacol. 121, 1509-1511
45. Pratt, P. F., Hillard, C. J., Edgemond, W. S., and Campbell, W. B. (1998) N-arachidonylethanolamide relaxation of bovine coronary artery is not mediated by CB1 cannabinoid receptor. Am. J. Physiol. 274, H375-H381
46. Munro, S., Thomas, K. L., and Abu-Shaar, M. (1093) Molecular characterization of a peripheral receptor for cannabinoids. Nature (London) 365, 61-65
47. Lee, M., Yang, K. H., and Kaminski, N. E. (1995) Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes. J. Pharmacol. Exp. Ther. 275, 529-536
48. Dorman, T., and Breslow, M.J. (1904) Altered Immune function after trauma and hemorrhage: what does it all mean? Crit. Care Med. 22, 1009-1070
49. Junger, W. G., Hoyt, D. B., Liu, F. C., Loomis, W. H., and Coimbra, R. (1996) Inummosuppression after endotoxin shock: the result of multiple antiinflammatory factors. J. Trauma 40, 702-709