Ceramide: A new second messenger of cannabinoid action

Trends in Pharmacological Sciences

Volumn 22, Issue 1, 2001, Pages 19-22

  Guzman M ^a   Galve Roperh, I ^a   Sanchez C ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CANNABINOID; CANNABINOID RECEPTOR; CANNABIS; CERAMIDE; ION CHANNEL; MITOGEN ACTIVATED PROTEIN KINASE; SPHINGOMYELIN;

APOPTOSIS; ARTICLE; DRUG MECHANISM; HUMAN; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SECOND MESSENGER; SIGNAL TRANSDUCTION;

EID: 0035147072     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01586-8     Document Type: Review

References (27)

1. Determination and characterization of a cannabinoid receptor in rat brain
2. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
3. Formation and inactivation of endogenous cannabinoid anandamide
4. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
5. A second endogenous cannabinoid that modulates long-term potentiation
6. Structure of a cannabinoid receptor and functional expression of the cloned cDNA
7. Molecular characterization of a peripheral receptor for cannabinoids
8. Pharmacology of cannabinoid receptor ligands
9. Regulation of ceramide production and apoptosis
10. Does ceramide play a role in neural cell apoptosis?
11. Regulation of sphingolipid and glycosphingolipid metabolism during neuronal growth and development
12. Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Δ9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes
13. The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme
14. Δ9-Tetrahydrocannabinol induces apoptosis in C6 glioma cells
15. Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
16. FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase
17. The WD repeat: A common architecture for diverse functions
18. CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway
19. The growth-related gene product β induces sphingomyelin hydrolysis and activation of c-Jun N-terminal kinase in rat cerebellar granule neurons
20. Effects of cannabinoids on energy metabolism
21. Ceramide in the eukaryotic stress response
22. Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis
23. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
24. De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase
25. The endocannabinoid system as a target for therapeutic drugs
26. The endogenous cannabinoid system and brain development
27. Heptahelical receptor signaling: Beyond the G protein paradigm