-
1
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
Borchelt D.R., Thinakaran G., Eckman C.B. et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17:1996;1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
-
2
-
-
0026745610
-
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
-
Citron M., Oltersdorf T., Haass C. et al. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 360:1992;672-674.
-
(1992)
Nature
, vol.360
, pp. 672-674
-
-
Citron, M.1
Oltersdorf, T.2
Haass, C.3
-
3
-
-
0029803744
-
Evidence that the 42- And 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities
-
Citron M., Diehl T.S., Gordon G., Biere A.L., Seubert P., Selkoe D.J. Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proc. Natl. Acad. Sci. USA. 93:1996;13170-13175.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13170-13175
-
-
Citron, M.1
Diehl, T.S.2
Gordon, G.3
Biere, A.L.4
Seubert, P.5
Selkoe, D.J.6
-
4
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
-
Citron M., Westaway D., Xia W. et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat. Med. 3:1997;67-72.
-
(1997)
Nat. Med.
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
-
5
-
-
0030769092
-
Alzheimer's Abeta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
-
Cook D.G., Forman M.S., Sung J.C. et al. Alzheimer's Abeta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nat. Med. 3:1997;1021-1023.
-
(1997)
Nat. Med.
, vol.3
, pp. 1021-1023
-
-
Cook, D.G.1
Forman, M.S.2
Sung, J.C.3
-
6
-
-
16044366039
-
Increased amyloidβ-42(43) in brains of mice expressing mutant presenilin 1
-
Duff K., Eckman C., Zehr C. et al. Increased amyloidβ-42(43) in brains of mice expressing mutant presenilin 1. Nature. 383:1996;710-713.
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
-
7
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate A., Chartier-Harlin M.-C., Mullan M. et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 349:1991;704-706.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.-C.2
Mullan, M.3
-
8
-
-
0028915895
-
Amyloid β protein (Aβ) in Alzheimer's disease brain
-
Gravina S.A., Ho L., Eckman C.B. et al. Amyloid β protein (Aβ) in Alzheimer's disease brain. J. Biol. Chem. 270:1995;7013-7016.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7013-7016
-
-
Gravina, S.A.1
Ho, L.2
Eckman, C.B.3
-
9
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J., Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 12:1991;383-388.
-
(1991)
Trends Pharmacol. Sci.
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
10
-
-
0032150877
-
Genetic dissection of Alzheimer's disease and related dementias: Amyloid and its relationship to tau
-
Hardy J., Duff K., Hardy K., Perez-Tur J., Hutton M. Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nat. Neurosci. 1:1998;355-358.
-
(1998)
Nat. Neurosci.
, vol.1
, pp. 355-358
-
-
Hardy, J.1
Duff, K.2
Hardy, K.3
Perez-Tur, J.4
Hutton, M.5
-
11
-
-
0030769091
-
Distinct sites of intracellular production for Alzheimer's disease Abeta40/42 amyloid peptides
-
Hartmann T., Bieger S.C., Brühl B. et al. Distinct sites of intracellular production for Alzheimer's disease Abeta40/42 amyloid peptides. Nat. Med. 3:1997;1016-1020.
-
(1997)
Nat. Med.
, vol.3
, pp. 1016-1020
-
-
Hartmann, T.1
Bieger, S.C.2
Brühl, B.3
-
12
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb L., Gordon M.N., McGowan E. et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4:1998;97-100.
-
(1998)
Nat. Med.
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
Gordon, M.N.2
McGowan, E.3
-
13
-
-
0029661424
-
Analysis of heterogeneous βa4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive western blot assay
-
Ida N., Hartmann T., Pantel J. et al. Analysis of heterogeneous βA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive western blot assay. J. Biol. Chem. 271:1996;22908-22914.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 22908-22914
-
-
Ida, N.1
Hartmann, T.2
Pantel, J.3
-
14
-
-
0028919919
-
Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome
-
Iwatsubo T., Mann D.M., Okada A., Suzuki N., Ihara Y. Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome. Ann. Neurol. 37:1995;294-299.
-
(1995)
Ann. Neurol.
, vol.37
, pp. 294-299
-
-
Iwatsubo, T.1
Mann, D.M.2
Okada, A.3
Suzuki, N.4
Ihara, Y.5
-
15
-
-
0031020909
-
Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease
-
Johnson-Wood K., Lee M., Motter R. et al. Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl. Acad. Sci. USA. 94:1997;1550-1555.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 1550-1555
-
-
Johnson-Wood, K.1
Lee, M.2
Motter, R.3
-
16
-
-
0032145289
-
Modulation of amyloid precursor protein processing by compounds with various mechanisms of action: Detection by liquid phase electrochemiluminescent system
-
Khorkova O.E., Patel K., Heroux J., Sahasrabudhe S. Modulation of amyloid precursor protein processing by compounds with various mechanisms of action: detection by liquid phase electrochemiluminescent system. J. Neurosci. Methods. 82:1998;159-166.
-
(1998)
J. Neurosci. Methods
, vol.82
, pp. 159-166
-
-
Khorkova, O.E.1
Patel, K.2
Heroux, J.3
Sahasrabudhe, S.4
-
17
-
-
0023916455
-
Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide
-
Kim K.S., Miller D.L., Sapienza V.J. et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci. Res. Commun. 2:1988;121-130.
-
(1988)
Neurosci. Res. Commun.
, vol.2
, pp. 121-130
-
-
Kim, K.S.1
Miller, D.L.2
Sapienza, V.J.3
-
18
-
-
0025013745
-
Detection and quantitation of amyloid b-peptide with 2 monoclonal antibodies
-
Kim K.S., Wen G.Y., Bancher C., Chen C.-M.J., Sapienza V.J., Hong H., Wisniewski H.M. Detection and quantitation of amyloid b-peptide with 2 monoclonal antibodies. Neurosci. Res. Commun. 7:1990;113-122.
-
(1990)
Neurosci. Res. Commun.
, vol.7
, pp. 113-122
-
-
Kim, K.S.1
Wen, G.Y.2
Bancher, C.3
Chen, C.-M.J.4
Sapienza, V.J.5
Hong, H.6
Wisniewski, H.M.7
-
20
-
-
0031821433
-
Tyrosine kinase assays adapted to homogeneous time-resolved fluorescence
-
Kolb A.J., Kaplita P.V., Hayes D.J., Park Y.-W., Pernell C., Major J.S., Mathis G. Tyrosine kinase assays adapted to homogeneous time-resolved fluorescence. Drug Discov. Today. 3:1998;333-342.
-
(1998)
Drug Discov. Today
, vol.3
, pp. 333-342
-
-
Kolb, A.J.1
Kaplita, P.V.2
Hayes, D.J.3
Park, Y.-W.4
Pernell, C.5
Major, J.S.6
Mathis, G.7
-
21
-
-
16044365171
-
The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
-
Lemere C.A., Lopera F., Kosik K.S. et al. The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology. Nat. Med. 2:1996;1146-1150.
-
(1996)
Nat. Med.
, vol.2
, pp. 1146-1150
-
-
Lemere, C.A.1
Lopera, F.2
Kosik, K.S.3
-
22
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E., Wasco W., Poorkaj P. et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science. 269:1995;973-977.
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
-
23
-
-
0028982454
-
Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease
-
Motter R., Vigo-Pelfrey C., Kholodenko D. et al. Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann. Neurol. 38:1995;643-648.
-
(1995)
Ann. Neurol.
, vol.38
, pp. 643-648
-
-
Motter, R.1
Vigo-Pelfrey, C.2
Kholodenko, D.3
-
24
-
-
0001772459
-
β-Amyloid and treatment opportunities for Alzheimer's disease
-
Sabbagh M.N., Galasko D., Thal L.J. β-Amyloid and treatment opportunities for Alzheimer's disease. Alzheimer's Dis. Rev. 3:1997;1-19.
-
(1997)
Alzheimer's Dis. Rev.
, vol.3
, pp. 1-19
-
-
Sabbagh, M.N.1
Galasko, D.2
Thal, L.J.3
-
25
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D., Eckman C., Jensen M. et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:1996;864-870.
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
26
-
-
0029784838
-
Amyloid beta-protein and the genetics of Alzheimer's disease
-
Selkoe D.J. Amyloid beta-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 271:1996;18295-18298.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 18295-18298
-
-
Selkoe, D.J.1
-
27
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R., Rogaev E.I., Liang Y. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:1995;754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
-
28
-
-
0028322017
-
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
-
Suzuki N., Cheung T.T., Cai X.D. et al. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science. 264:1994;1336-1340.
-
(1994)
Science
, vol.264
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.T.2
Cai, X.D.3
-
29
-
-
0029942495
-
Metabolism of the 'Swedish' amyloid precursor protein variant in Neuro2a (N2a) cells
-
Thinakaran G., Teplow D.B., Siman R., Greenberg B., Sisodia S.S. Metabolism of the 'Swedish' amyloid precursor protein variant in Neuro2a (N2a) cells. J. Biol. Chem. 271:1996;9390-9397.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 9390-9397
-
-
Thinakaran, G.1
Teplow, D.B.2
Siman, R.3
Greenberg, B.4
Sisodia, S.S.5
-
30
-
-
0030966774
-
Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons
-
Tienari P.J., Ida N., Ikonen E. et al. Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons. Proc. Natl. Acad. Sci. USA. 94:1997;4125-4130.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 4125-4130
-
-
Tienari, P.J.1
Ida, N.2
Ikonen, E.3
-
31
-
-
0031056184
-
Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down's syndrome
-
Tokuda T., Fukushima T., Ikeda S., Sekijima Y., Shoji S., Yanagisawa N., Tamaoka A. Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down's syndrome. Ann. Neurol. 41:1997;271-273.
-
(1997)
Ann. Neurol.
, vol.41
, pp. 271-273
-
-
Tokuda, T.1
Fukushima, T.2
Ikeda, S.3
Sekijima, Y.4
Shoji, S.5
Yanagisawa, N.6
Tamaoka, A.7
-
32
-
-
16944365745
-
Enhanced production and oligomerization of the 42-residue amyloid β-protein by Chinese hamster ovary cells stably expressing mutant presenilins
-
Xia W., Zhang J., Kholodenko D. et al. Enhanced production and oligomerization of the 42-residue amyloid β-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J. Biol. Chem. 272:1997;7977-7982.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 7977-7982
-
-
Xia, W.1
Zhang, J.2
Kholodenko, D.3
|