Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function

Cell Growth and Differentiation

Volumn 11, Issue 12, 2000, Pages 615-623

  Cogswell, J P ^a   Brown, C E ^a   Bisi, J E ^a   Neill, S D ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; PROTEIN TYROSINE PHOSPHATASE;

APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CENTROSOME; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR CELL LINE; XENOPUS;

ADENOVIRIDAE; BLOTTING, WESTERN; BREAST; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CELL DEATH; CELL SEPARATION; EPITHELIAL CELLS; FEMALE; FIBROBLASTS; FLOW CYTOMETRY; GENES, DOMINANT; HELA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, FLUORESCENCE; MITOSIS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; TIME FACTORS; TUMOR CELLS, CULTURED;

ADENOVIRIDAE;

EID: 0034520085     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Cell cycle checkpoints: Preventing an identity crisis
2. The genetics of cell cycle checkpoints
3. When check points fail
4. Genetic abnormalities in human cancers
5. How cells cycle towards cancer
6. The difficulty in separating sisters
7. Cancer cell cycles
8. cdc2 inhibitory kinases
9. cdc25 regulates the phosphorylation and activity of the Xenopus cdk2 protein kinase complex
10. Cell cycle regulation of cdk2 activity by phosphorylation of Thr160 and Tyr15
11. Human Weel maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase
12. cdc2
13. cdc2 on Thr-14 and Tyr-15 at the prophase/metaphase transition
14. Phosphorylation and activation of human cdc25-C by Cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis
15. Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity
16. Oscillation of MPF is accompanied by periodic association between cdc25 and cdc2-cyclinB
17. Regulation of the cdc25 protein during the cell cycle in Xenopus extracts
18. Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase block initiation of M-phase
19. Activation of p34(cdc2) protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34 (cdc2) on sites phosphorylated at mitosis
20. Phosphorylation and activation of the Xenopus cdc25 phosphatase in the absence of cdc2 and cdk2 kinase activity
21. Purification and molecular cloning of Plx1, a cdc25-regulatory kinase from Xenopus egg extracts
22. 2/M phase transition of the cell cycle in Xenopus eggs
23. Activated polo-like kinase plx1 is required at multiple points during mitosis in Xenopus laevis
24. Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles
25. Polo-like kinases: A team that plays throughout mitosis
26. Polo-like kinases: Positive regulators of cell division from start to finish
27. Expression and phophorylation of fibroblast-growth-factor-inducible kinase (Fnk) during cell-cycle progression
28. Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase
29. PRK a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas
30. The physical association and phosphorylation of cdc25C protein phosphatase by Prk
31. Identification of an early-growth-response gene encoding a novel protein kinase
32. 2/M phase transition in HeLa cells
33. Cell cycle regulation of the activity and subcellular localization of PLK1, a human protein kinase implicated in mitotic spindle function
34. PLK is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1
35. Monoclonal antibodies to mitotic cells
36. DNA topoisomerase IIα is the major chromosome protein recognized by the mitotic phosphoprotein antibody MPM-2
37. Cell-cycle regulated localization of tyrosine and threonine phosphoepitopes at the kinetochores of mitotic chromosomes
38. Phosphoproteins are components of mitotic microtubule organizing centers
39. cdc25 is one of the MPM-2 antigens involved in the activation of maturation promoting factor
40. The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes
41. Pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis
42. Antibody microinjection reveals an essential role for human polo-like kinase 1 (plk1) in the functional maturation of mitotic centrosomes
43. On the regulation and function of human polo-like kinase 1 (PLK1): Effects of overexpression on cell cycle progression
44. Association of polo-like kinase with α-,β-, and γ-tubulins in a stable complex
45. PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression
46. The polo-like kinase plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts
47. The polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
48. Microsurgical removal of centrosomes block cell reproduction and centriole generation in BSC-1 cells
49. Long term gene delivery into the livers of immunocompetant mice with E1/E4-defective adenoviruses
50. Integrins and anoikis
51. Functional dissociation of anoikis-like cell death and activity of stress-activated protein kinase
52. Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase
53. Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer
54. Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck
55. Fibronectin and its integrin receptors in cancer
56. The Admid system: Generation of recombinant adenoviruses by Tn7-mediated transposition in E. coli
57. Highly controlled gene expression using combinations of a tissue-specific promoter, recombinant adenovirus and a tetracycline-regulatable transcription factor
58. Fluorescent microtiter screening assay of immuno-cytochemically reactive antibodies