The increment of micronucleus frequency in cervical carcinoma during irradiation in vivo and its prognostic value for tumour radiocurability

British Journal of Cancer

Volumn 80, Issue 10, 1999, Pages 1599-1607

  Widel, M ^a   Jedrus S ^a   Owczarek, S ^a   Konopacka, M ^a   Lubecka, B ^a   Kolosza Z ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

Cervical carcinoma; Micronucleus assay; Predictive value; Radiotherapy

Indexed keywords

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER RADIOTHERAPY; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MICRONUCLEUS TEST; PRIORITY JOURNAL; RADIOSENSITIVITY; TUMOR BIOPSY; UTERINE CERVIX CARCINOMA;

ADULT; FEMALE; HUMANS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MIDDLE AGED; PROGNOSIS; RADIOTHERAPY DOSAGE; REMISSION INDUCTION; UTERINE CERVICAL NEOPLASMS;

EID: 0032988554     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690569     Document Type: Article

References (28)

1. Bakker PJM, Tukker LJ, Stap J, Veenhof CHN and Aten JA (1993) Micronuclei expression in tumours as a test for radiation sensitivity. Radiother Oncol 26: 69-72
2. Bush C and McMillan TJ (1993) Micronucleus formation in human tumour cells: lack of correlation with radiosensitivity. Br J Cancer 67: 102-106
3. Champion AR, Hanson JA, Court JB and Venables SE (1995) The micronucleus assay: an evaluation of its use in determining radiosensitivity in vitro. Mutagenesis 10: 203-208
4. Davidson SE, West CML, Roberts SA, Hendry JH and Hunter RD (1990) Radiosensitivity testing of primary cervical carcinoma; evaluation of intra-and inter-tumour heterogeneity. Radiother Oncol 18: 349-359
5. Fertil B and Malaise EP (1985) Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors. Analysis of 101 published survival curves. Int J Radait Oncol Biol Phys 11: 1699-1707
6. Girynsky T, Lubin R, Pignon JP, Chavaudra N, Gazean J, Dubray B, Cossci JM, Socic G and Fertil B (1992) Predictive value of in vitro radiosensitivity parameters in head and neck cancers and cervical carcinomas: preliminary correlations with local control and overall survival. Int J Radiat Oncol Biol Phys 25: 3-7
7. Heddle JA and Carrano AV (1977) The DNA content in micronuclei induced in mouse bone marrow by gamma irradiation: evidence that micronuclei arise from acentric chromosomal fragments. Mutat Res 44: 63-69
8. Johansen J, Streffer C, Fuhrmann C, Bentzen SM, Stausbøl-Grøn B, Overgaard M and Overgaard J (1998) Radiosensitivity of normal fibroblasts from breast cancer patients assessed by the micronucleus and colony assays. Int J Radiat Biol 73: 671-678
9. Mariya Y, Streffer C, Fuhrmann C and Wojcik A (1997) Correlation of radiation-induced micronucleus frequency with clonogenic survival in cells of one diploid and two tetraploid murine tumor cell lines ot the same origin. Radiat Res 147: 29-34
10. Midander J and Revesz I. (1980) The frequency of micronuclei as a measure of cell survival in irradiated cell populations. Int J Radiat Biol 38: 237-242
11. Schwartz JL, Mustafi R, Beckett MA, Czyzewski EA, Farhangi E, Grdina DJ, Rotmensch R and Weichselhaum RR (1991) Radiation-induced DNA double-strand break frequencies in human squamous cell lines of different radiation sensitivities. Int J Radiat Biol 59: 1341-1352
12. Schwartz JL, Mustafi R, Beckett MA and Weichselbaum RR (1996) DNA double-strand break rejoining rates, inherent radiation sensitivity and human tumour response to radiotherapy. Br J Cancer 74: 37-42
13. Shibamoto Y, Streffer C, Fuhrmann C and Budach V (1991) Tumor radiosensitivity prediction by the cytokinesis-block micronucleus assay. Radiat Res 128: 293-300
14. Shibamoto Y, Shibata T, Miyatake S, Oda Y, Manahe T, Ohshio G, Yagi K, Streffer C, Takahashi M and Abe M (1994) Assessment of the proliferative activity of human tumours using the cytokinesis-błock micronucleus assay. Br J Cancer 70:67-71
15. Shibamoto Y, Ike O, Shibata T, Takahashi M, Abe M and Streffer C (1998) The cytokinesis-block micronucleus assay for the prediction of proliferative activity and radiosensitivity of human tumors. In: Progress in Radio-Oncology VI, Kogelnik HD and Sedlmayer F (eds), pp, 509-515, Munduzzi Editore: Bologna, Italy
16. Slavotinek A, McMillan TJ and Steel CM (1993) A comparison of micronucleus frequency and radiation survival in lymphoblastoid cell lines, Mutagenesis 8: 569-575
17. Stap J and Aten JA (1990) Comparison of radiation sensitivity for three cell lines as measured by the cloning assay and the micro-nucleus test. Strahlenther Onkol 166: 761-763
18. Villa R, Zaffaroni N, Gornati D, Costa A and Silvestrini R (1994) Lack of correlation between micronucleus formation and radiosensitivity in established and primary cultures of human tumours. Br J Cancer 70: 1112-1117
19. Wandl EO, Ono K, Kain R, Herbsthofer T, Heinert G and Hobarth K (1989) Linear correlation between surviving fraction and the micronucleus frequency. Int J Radiat Biol 56: 771-775
20. Weissenhorn U and Streffer C (1991) Micronuclei with kinetochores in human melanoma cells and rectal carcinomas. Int J Radiat Biol 59: 373-383
21. West CML and Hendry JH (1992) Intrinsic radiosensitivity as a predictor of patient response to radiotherapy. Br J Radiol 24: 146-152
22. West CML, Davidson SE, Roberts SA and Hunter RD (1993) Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix. Br J Cancer 68: 819-823
23. West CML, Davidson SE, Roberts SA and Hunter RD (1997) The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix. Br J Cancer 76: 1184-1190
24. Whitaker SJ, Ung YC and McMillan TJ (1995) DNA double-strand break induction and rejoining as determinants of human tumour cell radiosensitivity. A pulsed-field gel electrophoresis study. Int J Radiat Biol 67: 7-18
25. Widel M, Dohrut M, Maka B, Lubecka B, Plucicnnik A (1997) The radiosensitivity of human malignant melanomas evaluated by cytokinesis-block micronucleus assay. Neoplasma 44: 109-116
26. Widel M, Konopacka M, Jedrus S and Owczarek S (1993) Evaluation of the human cervical carcinoma cells radiosensitivity by the micronucleus assay. Abstracts from Annual Meeting of ESRB, Stockholm, Sweden
27. Zamboglou N, Streffer C, Fritzmeir CU, Bojar H, Karstens JH, Schnabel T, Kolotas C and Schmitt G (1992) Klinische Prognose Faktoren der Radioresistenz by Kopf-Hals-Karzinomen. Dtsch Z Mund Kiefer Gesichhts Chir 16: 82-85
28. Zölzer F, Alberti W, Pelzer T, Lamberti G, Hulskamp PH and Streffer C (1995) Changes in S phase fraction and micronucleus frequency as prognostic factor in radiotherapy of cervical carcinoma. Radiother Oncol 36: 128-132